Compound ID | 766

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Etimicin

Synonym(s): Antibiotic 89-07  |  89-07

Class: Aminoglycoside

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Protein synthesis inhibitor. Binds to the 50S ribosomal subunit
Target Pathogen: Broad spectrum activity
Description: Semisynthetic derivative of gentamicin; Zhang Y and Li Z. A study on the postantibiotic effect (PAE) of 89-07, a new aminoglycoside. 35th-Intersci-Conf-Antimicrobial-Agents-Chemother 1995; 114.
Institute where first reported: Beijing Medical University, China
Year first mentioned: 1995
Highest development stage: Phase 1
Development status: Active
Reason dropped: Reports suggest risk of nephrotoxicity
Chemical structure(s):
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Molecular weight: 477.6
Iso. SMILES: CCN[C@@H]1C[C@@H]([C@H]([C@@H]([C@H]1O[C@@H]2[C@@H]([C@H]([C@@](CO2)(C)O)NC)O)O)O[C@@H]3[C@@H](CC[C@H](O3)CN)N)N
InChI Key: NZGMVSJQULXLHF-RAKCNUBFSA-N
Can. SMILES: CCN[C@@H]1C[C@@H]([C@H]([C@@H]([C@H]1O[C@@H]2[C@@H]([C@H]([C@](C)(CO2)O)NC)O)O)O[C@@H]3[C@@H](CC[C@@H](CN)O3)N)N
InChI: InChI=1S/C21H43N5O7/c1-4-26-13-7-12(24)16(32-19-11(23)6-5-10(8-22)31-19)14(27)17(13)33-20-15(28)18(25-3)21(2,29)9-30-20/h10-20,25-29H,4-9,22-24H2,1-3H3/t10-,11+,12-,13+,14-,15+,16+,17-,18+,19+,20+,21-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9912913
Citation: https://doi.org/10.1002/jat.4093

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