Compound ID | 773

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TP-271

Class: Tetracycline

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Protein synthesis inhibitor
Description: Fluorocycline
Institute where first reported: Tetraphase Pharmaceuticals, USA
Year first mentioned: 2010
Highest development stage: Phase 1 (NCT03450187)
Development status: Active
Chemical structure(s):
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Molecular weight: 558.56
Iso. SMILES: CN1CCC[C@H]1C(=O)NC2=CC(=C3C[C@H]4C[C@H]5[C@@H](C(=O)C(=C([C@]5(C(=O)C4=C(C3=C2O)O)O)O)C(=O)N)N(C)C)F
InChI Key: VIWUYPVRNWIKLS-HMFHYXQTSA-N
Can. SMILES: CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=C(C(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)NC(=O)[C@@H]5CCCN5C)F
InChI: InChI=1S/C27H31FN4O8/c1-31(2)19-12-8-10-7-11-13(28)9-14(30-26(39)15-5-4-6-32(15)3)20(33)17(11)21(34)16(10)23(36)27(12,40)24(37)18(22(19)35)25(29)38/h9-10,12,15,19,33-34,37,40H,4-8H2,1-3H3,(H2,29,38)(H,30,39)/t10-,12-,15-,19-,27-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/54726193
Guide to Pharmacology: TP-271
Citations:
  • https://doi.org/10.1128/aac.00448-17
  • https://doi.org/10.1128/msphere.00004-17

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