Compound ID | 778

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CL 331002

Synonym(s): CL-331002  |  CL331002  |  DMG-DMDOT

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Gram-positives and anaerobe Gram-negatives
Description: Synthetic compound of glycyline-type; 1. King A, May J and Phillips I. In vitro activity of CL-331928 (DMG.DMDOT) and CL-344677 (DMG-MINO) against clinical isolates of resistant Gram positive cocci. 35th-Intersci-Conf-Antimicrobial-Agents-Chemother 1995; 140. 2. Weiss WJ, Jjacobus NV, Petersen PJ, et al. In vitro activity of novel glycylcycline compounds against Enterococci and methicillin-resistant Staphylococci. 33rd-Intersci-Conf-Antimicrobial-Agents-Chemother 1993; 198.
Institute where first reported: Wyeth, USA
Year first mentioned: 1993
Development status: Experimental
Chemical structure(s):
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Molecular weight: 499.51
Iso. SMILES: CN(C)CC(=O)NC(=O)C1=C([C@@]2([C@@H](C[C@@H]3CC4=C(C(=CC=C4)O)C(=C3C2=O)O)[C@@H](C1=O)N(C)C)O)O
InChI Key: KFTLBUWBQDMTSQ-JNCWMXRTSA-N
Can. SMILES: CN(C)CC(=O)NC(=O)C1=C([C@@]2([C@@H](C[C@@H]3CC4=CC=CC(=C4C(=C3C2=O)O)O)[C@@H](C1=O)N(C)C)O)O
InChI: InChI=1S/C25H29N3O8/c1-27(2)10-15(30)26-24(35)18-21(32)19(28(3)4)13-9-12-8-11-6-5-7-14(29)16(11)20(31)17(12)22(33)25(13,36)23(18)34/h5-7,12-13,19,29,31,34,36H,8-10H2,1-4H3,(H,26,30,35)/t12-,13-,19-,25-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/54686193
Citation: https://doi.org/10.1093/jac/37.6.1171

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