Compound ID | 789

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TE-802

Class: Macrolide

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Staphylococcus aureus
Description: A ketolide; Asaka T, Kashimura M, Misawa Y, et al. A new macrolide antibiotic, TE-802; synthesis and biological properties. 35th-Intersci-Conf-Antimicrobial-Agents-Chemother 1995; 143.
Institute where first reported: Taisho Pharmaceuticals, Japan
Year first mentioned: 1995
Development status: Experimental
Chemical structure(s):
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Molecular weight: 637.81
Iso. SMILES: CC[C@@H]1[C@@]2([C@H]3[C@H](C(=NCCN3C(=O)O2)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]4[C@@H]([C@H](C[C@H](O4)C)N(C)C)O)(C)OC)C)C)C
InChI Key: JUXBXTDPLFNOCQ-NBQPNFJYSA-N
Can. SMILES: CC[C@@H]1[C@]2(C)[C@H]3[C@@H](C)C(=NCCN3C(=O)O2)[C@H](C)C[C@](C)([C@@H]([C@@H](C)C(=O)[C@@H](C)C(=O)O1)O[C@H]4[C@@H]([C@H](C[C@@H](C)O4)N(C)C)O)OC
InChI: InChI=1S/C33H55N3O9/c1-12-23-33(8)27-19(4)24(34-13-14-36(27)31(40)45-33)17(2)16-32(7,41-11)28(20(5)25(37)21(6)29(39)43-23)44-30-26(38)22(35(9)10)15-18(3)42-30/h17-23,26-28,30,38H,12-16H2,1-11H3/t17-,18-,19+,20+,21-,22+,23-,26-,27-,28-,30+,32-,33-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/479074
Citation: https://doi.org/10.7164/antibiotics.54.664

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