Compound ID | 79

Cefepime + enmetazobactam (Exblifep)

Synonym(s): AAI101  |  OCID 5090

Class: Beta-lactam (cephalosporin, fourth generation) + beta-lactamase inhibitor (penicillanic acid sulfone)

Spectrum of activity: Gram-negative
Details of activity: Active against Enterobacteriaceae; indicated for urinary tract infection, hospital and ventilation acquired bacterial pneumoniae, and complicated intraabdominal infection
Combined with other compounds: Yes
Institute where first reported: Allecra Therapeutics; Orchid Pharma
Year first mentioned: 2015
Highest developmental phase: Approved by FDA in 2024
Development status: Approved
External links:
Guide to Pharmacology: cefepime
Main Source: http://allecra.com/pipeline-2/
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584277/
  • http://www.ncbi.nlm.nih.gov/pubmed/25712356
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