Compound ID | 790

Update compound information

YM133

Synonym(s): 4"-O-(4-methoxyphenyl)acetyltylosin  |  IMC-XV

Class: Macrolide

Agent Type: Semisynthetic; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Broad spectrum Gram-positive activity
Institute where first reported: Institute of Microbial Chemistry; Yamanouchi Pharmaceutical; Astellas Pharma
Year first mentioned: 1990
Development status: Experimental
Chemical structure(s):
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Molecular weight:
Iso. SMILES: CCC1OC(=O)C[C@@H](O)[C@H](C)C(O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC4=CC=C(OC)C=C4)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)C=CC(=C[C@@H]1CO[C@@H]5O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]5OC)C
InChI Key: SHXNTUGMIOZCCG-IKFHPVHOSA-N
Can. SMILES: CCC1[C@H](C=C(C)C=CC(=O)[C@H](C)C[C@H](CC=O)C([C@@H](C)[C@@H](CC(=O)O1)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](C)O2)O[C@H]3C[C@](C)([C@H]([C@H](C)O3)OC(=O)CC4=CC=C(C=C4)OC)O)N(C)C)O)CO[C@H]5[C@@H]([C@@H]([C@@H]([C@@H](C)O5)O)OC)OC
InChI: InChI=1S/C55H85NO19/c1-14-41-37(28-68-54-51(67-13)50(66-12)46(62)32(5)70-54)23-29(2)15-20-39(58)30(3)24-36(21-22-57)48(31(4)40(59)26-43(61)72-41)75-53-47(63)45(56(9)10)49(33(6)71-53)74-44-27-55(8,64)52(34(7)69-44)73-42(60)25-35-16-18-38(65-11)19-17-35/h15-20,22-23,30-34,36-37,40-41,44-54,59,62-64H,14,21,24-28H2,1-13H3/t30-,31+,32-,33-,34+,36+,37-,40-,41?,44+,45-,46-,47-,48?,49-,50-,51-,52+,53+,54-,55-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/substance/274110959
Citation: https://doi.org/10.1128/aac.35.7.1370

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