Compound ID | 80

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MG96077

Class: Beta-lactamase inhibitor

Agent Type: Synthetic; Small molecule; Indirect acting; Antibiotic adjuvant;
Spectrum of activity: Gram-negative
Mechanism of action: Class A beta-lactamase inhibitor; class C beta-lactamase inhibitor
Target Pathogen: Active against beta-lactam-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae
Combined with other compounds: Yes
Description: A non-beta-lactam phosphonate-based compound
Institute where first reported: Mirati Therapeutics, USA
Year first mentioned: 2009
Highest development stage: Preclinical
Development status: Experimental
External links:
Citations:
  • https://www.biospace.com/article/releases/methylgene-presents-preclinical-data-for-its-beta-lactamase-inhibitor-mg96077-at-the-49th-annual-b-icaac-b-meeting-/
  • https://www.mdpi.com/2079-6382/3/2/193
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790266/pdf/antibiotics-02-00500.pdf
  • https://www.mdpi.com/2079-6382/3/2/193

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