Compound ID | 813

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PNU-177553

Class: Oxazolidinone

Spectrum of activity: Gram-positive
Description: 1. Schaadt R, Perricone S, Hester J, et al. In vitro antibacterial activity of PNU-177553, a novel antibacterial agent. 41st-ICAAC 2001;226-227 2. Watts JL, Salmon SA, Klein LK, et al. In vitro activity of PNU-177553 against atypical respiratory pathogens. 41st-ICAAC 2001;227
Institute where first reported: Pharmacia Corp. (Pfizer, USA)
Year first mentioned: 2001
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: When comparing linezolid and PNU-177553, there in vitro, there was cross resistance additionally testing against 23 strains of M. pneumoniae, linezolid's MIC ranged 1 - >32mg/ml compared with this compound's 4 - >32mg/ml
Chemical structure(s):
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Molecular weight: 385.48
Iso. SMILES: CC(=S)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCS(=O)CC3)F
InChI Key: XOLXODOYQGMVSK-ZDUSSCGKSA-N
Can. SMILES: CC(=S)NC[C@H]1CN(C2=CC=C(C(=C2)F)N3CCS(=O)CC3)C(=O)O1
InChI: InChI=1S/C16H20FN3O3S2/c1-11(24)18-9-13-10-20(16(21)23-13)12-2-3-15(14(17)8-12)19-4-6-25(22)7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,24)/t13-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9886431
Citation:

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