Compound ID | 815

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Ranbezolid (RBx 7644)

Class: Oxazolidinone

Spectrum of activity: Gram-positive
Details of activity: Bacterial protein inhibitor; Extended spectrum oxazolidinone with activity against biofilm formation whether these are planktonic S.aureus or slime producing sessile bacteria (1). It is also bacteriocidal against anaerobes (2).
Description: 1. Mathur T, Singhal S, Khan S, et al. Effect of ranbezolid (RBx 7644) on formation of staphylococcal biofilm. 44th-ICAAC 2004;221. 2. Mathur T, Singhal S, Khan S, et al. Ranbezolid (RBx 7644) has concentration dependent bacteriocidal actiivty against anaerobes. 44th-ICAAC 2004;221.
Institute where first reported: Ranbaxy Laboratories (Sun Pharmaceutical Industries, India)
Year first mentioned: 2004
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 461.44
Iso. SMILES: CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCN(CC3)CC4=CC=C(O4)[N+](=O)[O-])F
InChI Key: PWHNTOQANLCTHN-KRWDZBQOSA-N
Can. SMILES: CC(=O)NC[C@H]1CN(C2=CC=C(C(=C2)F)N3CCN(CC3)CC4=CC=C([N+](=O)[O-])O4)C(=O)O1
InChI: InChI=1S/C21H24FN5O6/c1-14(28)23-11-17-13-26(21(29)33-17)15-2-4-19(18(22)10-15)25-8-6-24(7-9-25)12-16-3-5-20(32-16)27(30)31/h2-5,10,17H,6-9,11-13H2,1H3,(H,23,28)/t17-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/496993
Guide to Pharmacology: ranbezolid
Citations:
  • https://www.sciencedirect.com/science/article/pii/S0924857904002109?via%3Dihub
  • https://www.tandfonline.com/doi/abs/10.1179/joc.2008.20.4.420

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