Ranbezolid (RBx 7644)

Class: Oxazolidinone

Spectrum of activity:	Gram-positive
Details of activity:	Bacterial protein inhibitor; Extended spectrum oxazolidinone with activity against biofilm formation whether these are planktonic S.aureus or slime producing sessile bacteria (1). It is also bacteriocidal against anaerobes (2).
Description:	1. Mathur T, Singhal S, Khan S, et al. Effect of ranbezolid (RBx 7644) on formation of staphylococcal biofilm. 44th-ICAAC 2004;221. 2. Mathur T, Singhal S, Khan S, et al. Ranbezolid (RBx 7644) has concentration dependent bacteriocidal actiivty against anaerobes. 44th-ICAAC 2004;221.
Institute where first reported:	Ranbaxy Laboratories (Sun Pharmaceutical Industries, India)
Year first mentioned:	2004
Highest developmental phase:	Preclinical
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	CC(=O)NC[C@H]1CN(C2=CC=C(C(=C2)F)N3CCN(CC3)CC4=CC=C([N+](=O)[O-])O4)C(=O)O1
Isomeric SMILES:	CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCN(CC3)CC4=CC=C(O4)[N+](=O)[O-])F
InChI:	InChI=1S/C21H24FN5O6/c1-14(28)23-11-17-13-26(21(29)33-17)15-2-4-19(18(22)10-15)25-8-6-24(7-9-25)12-16-3-5-20(32-16)27(30)31/h2-5,10,17H,6-9,11-13H2,1H3,(H,23,28)/t17-/m0/s1
InChI Key:	PWHNTOQANLCTHN-KRWDZBQOSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/496993

External links:
Guide to Pharmacology:	ranbezolid
Main Source:	https://www.tandfonline.com/doi/abs/10.1179/joc.2008.20.4.420
Citation:	https://www.sciencedirect.com/science/article/pii/S0924857904002109?via%3Dihub