Compound ID | 818

Update compound information

Rx-01 series: Rx-01_413

Class: Oxazolidinone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: 50S ribosomal subunit inhibitor; this series generally showed lower MICS against S. aureus and enterococcal isolates
Description: Lawrence L, Sutcliffe J. In vitro activity of designer oxazolidinones against respiratory pathogens. 45th-Intersci-Conf-Antimicrob-Agents-Chemother 2005;198.
Institute where first reported: Rib-X Pharmaceuticals (Melinta Therapeutics, USA)
Year first mentioned: 2005
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 409.41
Iso. SMILES: CC(=O)NC[C@H]1CN(C2=CC=C(C3=CC=C(CN4C=CN=N4)C=C3)C(F)=C2)C(=O)O1
InChI Key: YYIPDVZMBORVLM-SFHVURJKSA-N
Can. SMILES: CC(=O)NC[C@H]1CN(C2=CC=C(C3=CC=C(C=C3)CN4C=CN=N4)C(=C2)F)C(=O)O1
InChI: InChI=1S/C21H20FN5O3/c1-14(28)23-11-18-13-27(21(29)30-18)17-6-7-19(20(22)10-17)16-4-2-15(3-5-16)12-26-9-8-24-25-26/h2-10,18H,11-13H2,1H3,(H,23,28)/t18-/m0/s1
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Citation:

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