Compound ID | 819

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Rx-01 series: Rx-01_445

Class: Oxazolidinone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: 50S ribosomal subunit inhibitor; this series generally showed lower MICS against S. aureus and enterococcal isolates
Description: Lawrence L, Sutcliffe J. In vitro activity of designer oxazolidinones against respiratory pathogens. 45th-Intersci-Conf-Antimicrob-Agents-Chemother 2005;198.
Institute where first reported: Rib-X Pharmaceuticals (Melinta Therapeutics, USA)
Year first mentioned: 2005
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 410.4
Iso. SMILES: CC(=O)NC[C@H]1CN(C2=CC=C(C3=CC=C(CN4N=CN=N4)C=C3)C(F)=C2)C(=O)O1
InChI Key: MKWHQDXCSLNKCJ-KRWDZBQOSA-N
Can. SMILES: CC(=O)NC[C@H]1CN(C2=CC=C(C3=CC=C(C=C3)CN4N=CN=N4)C(=C2)F)C(=O)O1
InChI: InChI=1S/C20H19FN6O3/c1-13(28)22-9-17-11-26(20(29)30-17)16-6-7-18(19(21)8-16)15-4-2-14(3-5-15)10-27-24-12-23-25-27/h2-8,12,17H,9-11H2,1H3,(H,22,28)/t17-/m0/s1
External links:
Citation:

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