Compound ID | 820

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Radezolid

Synonym(s): Rx-01_667  |  RX-1741  |  Rx 01 667  |  RX 1741

Class: Oxazolidinone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Staphylococcus aureus including linezolid-resistant strains
Description: A biaryloxazolidinone; Lawrence L, Sutcliffe J. In vitro activity of designer oxazolidinones against respiratory pathogens. 45th-Intersci-Conf-Antimicrob-Agents-Chemother 2005;198.
Institute where first reported: Rib-X Pharmaceuticals (Melinta Therapeutics, USA)
Year first mentioned: 2005
Highest development stage: Phase 2 (NCT00646958)
Development status: Active
Chemical structure(s):
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Molecular weight: 438.46
Iso. SMILES: CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)C3=CC=C(C=C3)CNCC4=NNN=C4)F
InChI Key: BTTNOGHPGJANSW-IBGZPJMESA-N
Can. SMILES: CC(=O)NC[C@H]1CN(C2=CC=C(C3=CC=C(C=C3)CNCC4=NNN=C4)C(=C2)F)C(=O)O1
InChI: InChI=1S/C22H23FN6O3/c1-14(30)25-12-19-13-29(22(31)32-19)18-6-7-20(21(23)8-18)16-4-2-15(3-5-16)9-24-10-17-11-26-28-27-17/h2-8,11,19,24H,9-10,12-13H2,1H3,(H,25,30)(H,26,27,28)/t19-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/11224409
Guide to Pharmacology: radezolid
Citations:
  • https://doi.org/10.1016/j.bmcl.2008.10.014
  • https://doi.org/10.1128/aac.01723-09
  • https://doi.org/10.1016/j.bmcl.2008.10.011

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