Compound ID | 84

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FSI-1671

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Cell wall synthesis inhibitor
Target Pathogen: Active against infections caused by multidrug-resistant Gram-negatives
Description: A carbapenem
Institute where first reported: AstraZeneca (UK) + FOB Synthesis, Inc (USA)
Year first mentioned: 2014
Highest developmental phase: Preclinical
Development status: Experimental
Chemical structure(s):
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Molecular weight: 337.37
Iso. SMILES: CC1C2C(C(=O)N2C(=C1CN3CC(C3)N=C(N)N)C(=O)O)C(C)O
InChI Key: DAPHOGGWQZGDCJ-UHFFFAOYSA-N
Can. SMILES: CC1C(=C(C(=O)O)N2C1C(C(C)O)C2=O)CN3CC(C3)N=C(N)N
InChI: InChI=1S/C15H23N5O4/c1-6-9(5-19-3-8(4-19)18-15(16)17)12(14(23)24)20-11(6)10(7(2)21)13(20)22/h6-8,10-11,21H,3-5H2,1-2H3,(H,23,24)(H4,16,17,18)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/76192363
Citations:
  • https://www.ncbi.nlm.nih.gov/pubmed/23489027
  • http://www.fobsynthesis.com/F1-1201.pdf

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