Compound ID | 843

Update compound information

SB-264128

Class: Pleuromutilin

Details of activity: Protein synthesis inhibitor; tested for respiratory tract infections
Institute where first reported: SmithKline Beecham (GSK, US)
Year first mentioned: 2000
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Toxicity issues
Chemical structure(s):
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Molecular weight: 523.11
Iso. SMILES: C[C@@H]1CCC23CCC(=O)[C@H]2C1([C@@H](C[C@@]([C@H]([C@@H]3C)O)(C)C=C)OC(=O)NC(=O)C4CN5CC[C@@H]4C5)C.Cl
InChI Key: YIFQHSPOBMSHJO-WAINTNGGSA-N
Can. SMILES: C=C[C@]1(C)C[C@H](C2(C)[C@H](C)CCC3(CCC(=O)[C@@H]23)[C@@H](C)[C@@H]1O)OC(=O)NC(=O)C4CN5CC[C@@H]4C5.Cl
InChI: InChI=1S/C28H42N2O5.ClH/c1-6-26(4)13-21(35-25(34)29-24(33)19-15-30-12-9-18(19)14-30)27(5)16(2)7-10-28(17(3)23(26)32)11-8-20(31)22(27)28;/h6,16-19,21-23,32H,1,7-15H2,2-5H3,(H,29,33,34);1H/t16-,17+,18-,19?,21-,22+,23+,26-,27?,28?;/m1./s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/169446277
Citation:

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