Compound ID | 844

Update compound information

SB-247386

Synonym(s): SB247386  |  SB 247386

Class: Pleuromutilin

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor. Peptidyl transferase inhibitor and interacts with domain V of the 23S RNA
Target Pathogen: Active against Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pyrogenes
Description: Semisynthetic compound derived from the natural product pleuromutilin; reviewed for topical treatment of skin disorders and respiratory tract infections
Institute where first reported: SmithKline Beecham; GSK
Year first mentioned: 1999
Development status: Experimental
Chemical structure(s):
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Molecular weight:
Iso. SMILES: CC1CCC23CCC(=O)C2C1(C(CC(C(C3C)O)(C)C=C)OC(=O)NC(=O)C45CCN(CC4)CC5)C
InChI Key: KFMPHTOYYHFVCB-UHFFFAOYSA-N
Can. SMILES: C=CC1(C)CC(C2(C)C(C)CCC3(CCC(=O)C23)C(C)C1O)OC(=O)NC(=O)C45CCN(CC4)CC5
InChI: InChI=1S/C29H44N2O5/c1-6-26(4)17-21(36-25(35)30-24(34)28-11-14-31(15-12-28)16-13-28)27(5)18(2)7-9-29(19(3)23(26)33)10-8-20(32)22(27)29/h6,18-19,21-23,33H,1,7-17H2,2-5H3,(H,30,34,35)
External links:
Citation: https://doi.org/10.1016/S1094-5539(03)00050-6

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