Compound ID | 845

Update compound information

SB-268091

Synonym(s): SB 268091  |  SB268091

Class: Pleuromutilin

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pyrogenes
Description: Semisynthetic compound derived from pleuromutilin; reviewed for topical treatment of skin disorders and respiratory tract infections
Institute where first reported: SmithKline Beecham (GSK, US)
Year first mentioned: 1999
Development status: Experimental
Chemical structure(s):
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Molecular weight:
Iso. SMILES: CC1CCC23CCC(=O)C2C1(C(CC(C(C3C)O)(C)C=C)OC(=O)CSC45CCN(CC4)CC5)C
InChI Key: YCLRVZOPBZJOCL-UHFFFAOYSA-N
Can. SMILES: C=CC1(C)CC(C2(C)C(C)CCC3(CCC(=O)C23)C(C)C1O)OC(=O)CSC45CCN(CC4)CC5
InChI: InChI=1S/C29H45NO4S/c1-6-26(4)17-22(34-23(32)18-35-28-11-14-30(15-12-28)16-13-28)27(5)19(2)7-9-29(20(3)25(26)33)10-8-21(31)24(27)29/h6,19-20,22,24-25,33H,1,7-18H2,2-5H3
External links:
Citation: https://doi.org/10.1021/op300263w

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