Compound ID | 846
Rx100472
Class: Aminoacyl-tRNA synthetase inhibitor (methionyl tRNA synthetase [MetRS] inhibitor , pyrimidine)
| Spectrum of activity: | Gram-negative |
| Details of activity: | Potency against most Gram positves tested but demonstrated poor activity against most Gram negatives. In mouse models, efficacy was shown against S. aureus and B. anthacis infections. |
| Description: | 1. Brown-Driver V, Li X, Stidham M, et al. In vivo efficacy of Rx100472, a novel methionyl tRNA synthetase inhibitor. 48-ICAAC-46-IDSA-2008 2008;279 2. Brown-Driver V, Li X, Shaadt R, et al. In vitro activity of Rx100472 against clinically important bacteria . 48-ICAAC-46-IDSA-2008 2008;280 |
| Institute where first reported: | Trius Therapeutics (Merck & Co., USA) |
| Year first mentioned: | 2008 |
| Highest developmental phase: | Preclinical |
| Development status: | Inactive |
| External links: | |
| Citation: |
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