Compound ID | 846
Rx100472
Class: Small molecule antibacterial agent
| Agent Type: | Synthetic; Small molecule; Direct acting; |
| Spectrum of activity: | Gram-positive |
| Mechanism of action: | Protein synthesis inhibitor. Aminoacyl-tRNA synthetase inhibitor; methionyl tRNA synthetase [MetRS] inhibitor |
| Target Pathogen: | Active against Gram-positives including Bacillus anthracis |
| Description: | 1. Brown-Driver V, Li X, Stidham M, et al. In vivo efficacy of Rx100472, a novel methionyl tRNA synthetase inhibitor. 48-ICAAC-46-IDSA-2008 2008;279 2. Brown-Driver V, Li X, Shaadt R, et al. In vitro activity of Rx100472 against clinically important bacteria . 48-ICAAC-46-IDSA-2008 2008;280 |
| Institute where first reported: | Trius Therapeutics (Merck & Co., USA) |
| Year first mentioned: | 2008 |
| Development status: | Experimental |
| External links: |
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