Compound ID | 853

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MCB3681

Synonym(s): MCB-3681  |  MCB 3681

Class: Oxazolidinone, Quinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Unknown
Target Pathogen: Active against ciprofloxacin-resistant bacteria, vancomycin-resistant Enterococcus, and oxafoxacin-resistant Staphylococci
Description: A combination of oxazolidinone and quinolone; active component of the water-soluble prodrug MCB3837
Institute where first reported: Institute for Infection Med., Germany
Year first mentioned: 2006
Highest development stage: Phase 2
Development status: Active
Chemical structure(s):
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Molecular weight: 626.61
Iso. SMILES: CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)OCC3(CCN(CC3)C4=C(C=C5C(=C4)N(C=C(C5=O)C(=O)O)C6CC6)F)O)F
InChI Key: YEDRNPDLVCNIAV-FQEVSTJZSA-N
Can. SMILES: CC(=O)NC[C@H]1CN(C2=CC=C(C(=C2)F)OCC3(CCN(CC3)C4=CC5=C(C=C4F)C(=O)C(=CN5C6CC6)C(=O)O)O)C(=O)O1
InChI: InChI=1S/C31H32F2N4O8/c1-17(38)34-13-20-14-37(30(42)45-20)19-4-5-27(24(33)10-19)44-16-31(43)6-8-35(9-7-31)26-12-25-21(11-23(26)32)28(39)22(29(40)41)15-36(25)18-2-3-18/h4-5,10-12,15,18,20,43H,2-3,6-9,13-14,16H2,1H3,(H,34,38)(H,40,41)/t20-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/11273606
Citations:
  • https://doi.org/10.1016/j.anaerobe.2014.07.001
  • https://doi.org/10.1128/AAC.02077-16
  • https://doi.org/10.1016/j.cmi.2015.05.025
  • https://doi.org/10.1128/aac.02473-14

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