BC-3205

Class: Pleuromutilin

Spectrum of activity:	Gram-negative
Details of activity:	Protein synthesis inhibitor. Potent activity against Gram positives including MRSA, Enterococci strains, H. influenzaeand M. catarrhalis with MIC90 ranging from 0.06- 4 µg/ml)
Institute where first reported:	Nabriva Therapeutics, Austria
Year first mentioned:	2009
Highest developmental phase:	Phase 1
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	C=C[C@]1(C)C[C@H]([C@]2(C)[C@H](C)CC[C@]3(CCC(=O)[C@@H]23)[C@@H](C)[C@@H]1O)OC(=O)CSC4CCCN(C4)C(=O)[C@@H](C(C)C)N
Isomeric SMILES:	C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@@]1([C@@H](C[C@@]([C@H]([C@@H]3C)O)(C)C=C)OC(=O)CSC4CCCN(C4)C(=O)[C@@H](C(C)C)N)C
InChI:	InChI=1S/C32H52N2O5S/c1-8-30(6)16-24(31(7)20(4)11-13-32(21(5)28(30)37)14-12-23(35)27(31)32)39-25(36)18-40-22-10-9-15-34(17-22)29(38)26(33)19(2)3/h8,19-22,24,26-28,37H,1,9-18,33H2,2-7H3/t20-,21+,22?,24-,26-,27+,28+,30-,31+,32+/m1/s1
InChI Key:	AFYOQRIZFPJUAR-UBTCORFISA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/44205184

External links:
Guide to Pharmacology:	BC-3205
Citations:	https://www.jmilabs.com/data/posters/ICAAC2009/F1-1513.PDF https://www.nabriva.com/Portals/_default/Skins/ProfessionalUs/pdfs/2010-bc-3205-skin-infections.pdf