Compound ID | 856

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BC-3205

Synonym(s): BC3205  |  BC 3205

Class: Pleuromutilin

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Gram-positives causing skin and skin structure infections and Gram-negatives causing community-acquired respiratory tract infections
Institute where first reported: Nabriva Therapeutics, Austria
Year first mentioned: 2009
Highest development stage: Phase 1
Development status: Inactive
Chemical structure(s):
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Molecular weight: 576.83
Iso. SMILES: C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@@]1([C@@H](C[C@@]([C@H]([C@@H]3C)O)(C)C=C)OC(=O)CSC4CCCN(C4)C(=O)[C@@H](C(C)C)N)C
InChI Key: AFYOQRIZFPJUAR-UBTCORFISA-N
Can. SMILES: C=C[C@]1(C)C[C@H]([C@]2(C)[C@H](C)CC[C@]3(CCC(=O)[C@@H]23)[C@@H](C)[C@@H]1O)OC(=O)CSC4CCCN(C4)C(=O)[C@@H](C(C)C)N
InChI: InChI=1S/C32H52N2O5S/c1-8-30(6)16-24(31(7)20(4)11-13-32(21(5)28(30)37)14-12-23(35)27(31)32)39-25(36)18-40-22-10-9-15-34(17-22)29(38)26(33)19(2)3/h8,19-22,24,26-28,37H,1,9-18,33H2,2-7H3/t20-,21+,22?,24-,26-,27+,28+,30-,31+,32+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/44205184
Guide to Pharmacology: BC-3205
Citations:
  • https://www.jmilabs.com/data/posters/ICAAC2009/F1-1513.PDF
  • https://doi.org/10.1128/jcm.01294-12
  • http://dx.doi.org/10.2174/15680266113136660217

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