Compound ID | 863

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E-4767

Class: Quinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: E-4767 was tested on E. coli and S. aureuswhich resulted in MIC(90) values lower or equal to 0.007mcg/ml. These values were around half those of ciprofloxacin. In general against tested Gram positive organisms, E-4767 wass more active than tosufloxacin.
Description: Gargallo-viola D, Ferrer S, Tudela E, et al. Antibacterial activities and pharmacokinetics of E-4767 and E-5065, two new 8-chlorofluoroquinolones with a 7-azetidin ring substituent. Antimicrob Agents Chemother. 2001;45(11):3113-21.
Institute where first reported: Esteve, Spain
Year first mentioned: 1993
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 365.79
Iso. SMILES: CC1C(CN1C2=C(C=C3C(=C2Cl)N(C=C(C3=O)C(=O)O)C4CC4)F)N
InChI Key: FGAPXYWEQVSGDJ-UHFFFAOYSA-N
Can. SMILES: CC1C(CN1C2=C(C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(=O)O)Cl)N
InChI: InChI=1S/C17H17ClFN3O3/c1-7-12(20)6-21(7)15-11(19)4-9-14(13(15)18)22(8-2-3-8)5-10(16(9)23)17(24)25/h4-5,7-8,12H,2-3,6,20H2,1H3,(H,24,25)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/15189039
Citation:

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