Compound ID | 864

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NM394

Synonym(s): NM-394  |  NM 394

Class: Quinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor
Target Pathogen: Broad spectrum activity
Description: Active form of the lipophilic prodrug NM441
Institute where first reported: St Marianna University, Japan
Year first mentioned: 1992
Development status: Experimental
Chemical structure(s):
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Molecular weight: 349.38
Iso. SMILES: CC1N2C3=CC(=C(C=C3C(=O)C(=C2S1)C(=O)O)F)N4CCNCC4
InChI Key: SUXQDLLXIBLQHW-UHFFFAOYSA-N
Can. SMILES: CC1N2C3=C(C=C(C(=C3)N4CCNCC4)F)C(=O)C(=C2S1)C(=O)O
InChI: InChI=1S/C16H16FN3O3S/c1-8-20-11-7-12(19-4-2-18-3-5-19)10(17)6-9(11)14(21)13(16(22)23)15(20)24-8/h6-8,18H,2-5H2,1H3,(H,22,23)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/124225
Citations:
  • https://www.ncbi.nlm.nih.gov/pubmed/8758474
  • https://doi.org/10.1128/aac.37.4.793
  • https://doi.org/10.1128/aac.40.3.739

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