Compound ID | 865

Update compound information

PD-117558

Synonym(s): PD 117558  |  99734-97-1

Class: Fluoroquinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Broad spectrum antibiotic; this showed potent activity against Gram positives including MRSA. It is also very active against Gram negative bacilli except Pseudomonas
Description: Domagala, J, M et al "The synthesis and structure activity relationshopd of a new quinolone antibacterial agent, PD-117,558" Program and Abstracts of the interscience science Conference on Antimicro0bial Agents and Chemotherapy. 1986.
Institute where first reported: Parke-Davis Pharmaceutical (Pfizer, USA); Warner-Lambert
Year first mentioned: 1986
Highest developmental phase: Preclinical
Development status: Experimental
Reason Dropped: Activity was less than imipenem and ceftazidime (2)
Chemical structure(s):
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Molecular weight: 391.41
Iso. SMILES: CCNCC1CCN(C1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)C4CC4)F
InChI Key: WDBGUJBLPRXPIX-UHFFFAOYSA-N
Can. SMILES: CCNCC1CCN(C1)C2=C(C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(=O)O)F
InChI: InChI=1S/C20H23F2N3O3/c1-2-23-8-11-5-6-24(9-11)18-15(21)7-13-17(16(18)22)25(12-3-4-12)10-14(19(13)26)20(27)28/h7,10-12,23H,2-6,8-9H2,1H3,(H,27,28)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/73366
Citations:
  • http://jac.oxfordjournals.org/content/23/3/363.full.pdf
  • https://pubmed.ncbi.nlm.nih.gov/2732120/

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