Compound ID | 865

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PD 117558

Synonym(s): 99734-97-1  |  PD117558  |  PD-117558

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor
Target Pathogen: Broad spectrum activity except Pseudomonas aeruginosa
Description: Domagala, J, M et al "The synthesis and structure activity relationshop of a new quinolone antibacterial agent, PD-117,558" Program and Abstracts of the interscience science Conference on Antimicrobial Agents and Chemotherapy. 1986.
Institute where first reported: Parke-Davis Pharmaceutical (Pfizer, USA); Warner-Lambert
Year first mentioned: 1986
Development status: Experimental
Reason dropped: Activity was less than imipenem and ceftazidime
Chemical structure(s):
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Molecular weight: 391.41
Iso. SMILES: CCNCC1CCN(C1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)C4CC4)F
InChI Key: WDBGUJBLPRXPIX-UHFFFAOYSA-N
Can. SMILES: CCNCC1CCN(C1)C2=C(C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(=O)O)F
InChI: InChI=1S/C20H23F2N3O3/c1-2-23-8-11-5-6-24(9-11)18-15(21)7-13-17(16(18)22)25(12-3-4-12)10-14(19(13)26)20(27)28/h7,10-12,23H,2-6,8-9H2,1H3,(H,27,28)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/73366
Citation: https://doi.org/10.1093/jac/23.3.363

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