Compound ID | 881

Update compound information

SEP 118843

Synonym(s): SEP-118843  |  SEP118843

Class: Membrane-active agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Membrane-active agent. Non-lytic; also reported to be an RNA synthesis inhibitor
Target Pathogen: Active against Staphylococcus aureus
Institute where first reported: Sepracor (Sunovion Pharmaceuticals, Inc)
Year first mentioned: 2000
Development status: Experimental
Chemical structure(s):
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Molecular weight: 593.51
Iso. SMILES: BrC1=CC2=C(C=C1)NC=C2C3=NC4=CC=C(C#CCN5CCCCC5)C=C4C(C(NC6=CC([H])=C(OC)C=C6)=O)=C3
InChI Key: HJNKYMGNZHRQQS-UHFFFAOYSA-N
Can. SMILES: COC1=C([H])C=C(C=C1)NC(=O)C2=CC(=NC3=C2C=C(C#CCN4CCCCC4)C=C3)C5=CNC6=C5C=C(C=C6)Br
InChI: InChI=1S/C33H29BrN4O2/c1-40-25-11-9-24(10-12-25)36-33(39)28-20-32(29-21-35-30-14-8-23(34)19-27(29)30)37-31-13-7-22(18-26(28)31)6-5-17-38-15-3-2-4-16-38/h7-14,18-21,35H,2-4,15-17H2,1H3,(H,36,39)
External links:
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151732/
  • https://journals.asm.org/doi/full/10.1128/aac.47.2.458-466.2003?cited-by=yes&legid=aac%3B47%2F2%2F458

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