Compound ID | 887

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SEP 156131

Class: Quinoline-indole

Spectrum of activity: Gram-negative
Details of activity: Lysis followed bacteria death, thought to be related to membrane damage
Institute where first reported: Sepracor (Sunovion Pharmaceuticals, Inc)
Year first mentioned: 2000
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 445.34
Iso. SMILES: ClC1=CC=C2C(N=C(C3=CNC4=C3C=C(Cl)C=C4)C=C2CNCC(C(CN)O)O)=C1
InChI Key: BOEDCGULHRPFSI-UHFFFAOYSA-N
Can. SMILES: C1=CC2=C(C=C1Cl)N=C(C=C2CNCC(C(CN)O)O)C3=CNC4=C3C=C(C=C4)Cl
InChI: InChI=1S/C22H22Cl2N4O2/c23-13-2-4-18-16(6-13)17(10-27-18)19-5-12(9-26-11-22(30)21(29)8-25)15-3-1-14(24)7-20(15)28-19/h1-7,10,21-22,26-27,29-30H,8-9,11,25H2
External links:
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151732/
  • https://journals.asm.org/doi/full/10.1128/aac.47.2.458-466.2003?cited-by=yes&legid=aac%3B47%2F2%2F458

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