Cefiderocol (Fetroja)

Synonym(s): S-649266  |  GSK-2696266  |  RSC 649266

Class: Beta-lactam (cephalosporin)

Spectrum of activity:	Gram-negative
Details of activity:	Health care-associated pneumonia, bloodstream infections, hospital-acquired bacterial pneumonia, ventilator-associated bacterial pneumonia, complicated urinary tract infections
Description:	First approved siderophore-antibiotic conjugate
Institute where first reported:	Shionogi, Japan
Year first mentioned:	2013
Highest developmental phase:	Approved by FDA in 2019
Development status:	Approved

Chemical structure(s):
Canonical SMILES:	CC(C)(C(=O)O)O/N=C(/C1=CSC(=N1)N)\C(=O)N[C@@H]2C(=O)N3C(=C(C[N+]4(CCCC4)CCNC(=O)C5=CC=C(C(=C5Cl)O)O)CS[C@H]23)C(=O)[O-]
Isomeric SMILES:	CC(C)(C(=O)O)O/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4(CCCC4)CCNC(=O)C5=C(C(=C(C=C5)O)O)Cl)C(=O)[O-]
InChI:	InChI=1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1
InChI Key:	DBPPRLRVDVJOCL-FQRUVTKNSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/77843966

External links:
Guide to Pharmacology:	cefiderocol
Main Source:	https://www.shionogi.com/category/cefiderocol/
Citations:	https://www.ncbi.nlm.nih.gov/pubmed/29960205 https://www.ncbi.nlm.nih.gov/pubmed/30712199