Compound ID | 900
GSQ 7302
Class: RNA synthesis inhibitor (hetero ARomatic Polyamide [HARP])
| Spectrum of activity: | Gram-negative |
| Details of activity: | Noncovalent binding in the minor groove of DNA results in inhibition of DNA replication and DNA-dependent RNA transcription and subsequent bacterial growth. |
| Institute where first reported: | Oscient Pharmaceuticals |
| Year first mentioned: | 2001 |
| Highest developmental phase: | Preclinical |
| Development status: | Inactive |
| Reason Dropped: | Symmetrical compounds- not very drug like- and acted on the minor groove of DNA, which made them very active but relatively non-selective- (JS, 2) Additionally, Oscient went bankrupt in 2009. HARPs were first worked on by Genesoft which merged with Oscient - and change of personnel working on the project- (LS) |
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