Compound ID | 902

Update compound information

AM-114

Class: Beta-lactamase inhibitor (oxapenem)

Combined with other compounds: ß-Lactams e.g. ceftazidime (CAZ) or cefaclor (CCL)
Institute where first reported: Amura; Micron Research
Year first mentioned: 2002
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: This was not a sufficiently more potent, broad spectrum inhibitor of type A and C beta-lactamases. Eventually, newer beta-lactamase inhibitors were developed [like avibactam] - (LS)
Chemical structure(s):
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Molecular weight: 377.01
Iso. SMILES: B(O)(O)C1=CC=C(C=C1)/C=C/2\C(=O)/C(=C\C3=CC=C(C=C3)B(O)O)/CN(C2)C
InChI Key: SRPIKXGUPAKTIZ-APGQMXJTSA-N
Can. SMILES: CN1C/C(=C/C2=CC=C(C=C2)B(O)O)/C(=O)/C(=C\C3=CC=C(C=C3)B(O)O)/C1
InChI: InChI=1S/C20H21B2NO5/c1-23-12-16(10-14-2-6-18(7-3-14)21(25)26)20(24)17(13-23)11-15-4-8-19(9-5-15)22(27)28/h2-11,25-28H,12-13H2,1H3/b16-10-,17-11-
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/72941923
Citation: https://journals.asm.org/doi/10.1128/aac.47.8.2615-2618.2003

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