Avycaz/Zavicefta (Ceftazidime/Avibactam)

Class: Drug combination: beta-lactam (cephalosporin) + beta-lactamase inhibitor

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Bacterial infections including gram-negative. Complicated urinary tract infections, complicated intra-abdominal infections, acute pyelonephritis (kidney infection), hospital-acquired bacterial pneumonia/ ventilator-associated bacterial pneumonia
Combined with other compounds:	Yes
Institute where first reported:	Pfizer Inc./Allergan PLC (formerly Actavis)
Year first mentioned:	2005
Highest developmental phase:	Approved by FDA in 2015
Development status:	Approved

Chemical structure(s):
Canonical SMILES:	CC(C)(C(=O)O)ON=C(C1=CSC(=N1)N)C(=O)NC2C(=O)N3C(=C(C[N+]4=CC=CC=C4)CSC23)C(=O)[O-]
Isomeric SMILES:	CC(C)(C(=O)O)ON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC=CC=C4)C(=O)[O-]
InChI:	InChI=1S/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)
InChI Key:	ORFOPKXBNMVMKC-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/9835049
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/ceftazidime

External links:
Guide to Pharmacology:	ceftazidime
Main Source:	https://www.pfizer.com/news/press-release/press-release-detail/pfizer_completes_acquisition_of_small_molecule_anti_infective_business_from_astrazeneca
Citations:	http://aac.asm.org/content/57/7/3178.full http://aac.asm.org/content/58/11/6490.full https://www.escmid.org/escmid_publications/escmid_elibrary/?q=Ceftaroline%2BAvibactam&id=2173&L=0&x=9&y=26