Compound ID | 928

Update compound information

CP-74667

Class: Fluoroquinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Of 750 clinical isolates including: MRSA, VRE, P. aeruginosa, S. pneumoniae, N. gonorrhoeae, M. catarrhalis and P. mirabilis and more, 90% of these strains were inhibited at <2µg/ml. Drug resistant strains were also tested including ciprofloxacin resistant MRSA which was inhibited at 4µg/ml. In laboratory animals, there was `00% bioavailability with long elimination time and wide distribution in tissues
Description: Gu JW, Fang W, Chin NX, et al. The in vitro activity of CP-74,667 a new fluoroquinolone compared to toher quinolones. 31st-ICAAC 1991;339.
Institute where first reported: Pfizer, USA
Year first mentioned: 1991
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 371.41
Iso. SMILES: CN1[C@@H]2CC[C@H]1CN(C2)C3=C(C=C4C(=C3)N(C=C(C4=O)C(=O)O)C5CC5)F
InChI Key: ALRZZABRVIYCNY-BETUJISGSA-N
Can. SMILES: CN1[C@H]2CC[C@@H]1CN(C2)C3=CC4=C(C=C3F)C(=O)C(=CN4C5CC5)C(=O)O
InChI: InChI=1S/C20H22FN3O3/c1-22-12-4-5-13(22)9-23(8-12)18-7-17-14(6-16(18)21)19(25)15(20(26)27)10-24(17)11-2-3-11/h6-7,10-13H,2-5,8-9H2,1H3,(H,26,27)/t12-,13+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/44371353
Citations:
  • http://www.ncbi.nlm.nih.gov/pubmed/1329625
  • https://www.sciencedirect.com/science/article/pii/073288939090039X?via%3Dihub

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