Compound ID | 929

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WIN 57273

Class: Fluoroquinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Broad spectrum antibiotic with MIC90s <0.5µg/ml. Antibacterial activity against gentamicin resistant E. faecalisand is able to kill 99.5% after 4 hrs in comparison to penicillin which kills 97.1% in 4hrs.
Description: Noskin G, Mehls P and Warren J. Bactericidal activity of WIN 57273 against high-level gentamicin resistant Enterococcus faecalis. 32nd-Intersci-Conf-Antimicrobial-Agents-Chemother 1992; 238.
Institute where first reported: Sanofi Winthrop (Sanofi Aventis, France)
Year first mentioned: 1989
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 352.36
Iso. SMILES: CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4CC4)F
InChI Key: FNKLCGHPPNAPBJ-UHFFFAOYSA-N
Can. SMILES: CC1=NC(=CC(=C1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4CC4)F)C
InChI: InChI=1S/C20H17FN2O3/c1-10-5-12(6-11(2)22-10)14-8-18-15(7-17(14)21)19(24)16(20(25)26)9-23(18)13-3-4-13/h5-9,13H,3-4H2,1-2H3,(H,25,26)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/121960
Citations:
  • http://www.ncbi.nlm.nih.gov/pubmed/2327779
  • https://journals.asm.org/doi/10.1128/aac.34.2.306

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