Compound ID | 93
Class: Drug combination: beta-lactam (cephalosporin, fourth generation) + beta-lactamase inhibitor (penicillanic acid sulfone)
Spectrum of activity: | Gram-negative |
Details of activity: | Approved for: complicated urinary tract infections, complicated intra-abdominal infections, acute pyelonephritis (kidney infection); other potential indications: hospital-acquired bacterial pneumonia/ ventilator-associated pneumonia |
Combined with other compounds: | Yes |
Institute where first reported: | Cubist Pharmaceuticals; Merck & Co; Astellas Pharma |
Year first mentioned: | 2012 |
Highest developmental phase: | Approved by FDA in 2014 |
Development status: | Approved |
Chemical structure(s): | |
Canonical SMILES: | CC(C)(C(=O)O)O/N=C(\C1=NSC(=N1)N)/C(=O)N[C@@H]2C(=O)N3C(=C(C[N+]4=CC(=C(N)N4C)NC(=O)NCCN)CS[C@H]23)C(=O)[O-].C[C@]1(CN2C=CN=N2)[C@H](C(=O)O)N3C(=O)CC3S1(=O)=O |
Isomeric SMILES: | C[C@@]1([C@@H](N2C(S1(=O)=O)CC2=O)C(=O)O)CN3C=CN=N3.CC(C)(C(=O)O)O/N=C(\C1=NSC(=N1)N)/C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=CC(=C(N4C)N)NC(=O)NCCN)C(=O)[O-] |
InChI: | InChI=1S/C23H30N12O8S2.C10H12N4O5S/c1-23(2,20(40)41)43-31-11(15-30-21(26)45-32-15)16(36)29-12-17(37)35-13(19(38)39)9(8-44-18(12)35)6-34-7-10(14(25)33(34)3)28-22(42)27-5-4-24;1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h7,12,18,25H,4-6,8,24H2,1-3H3,(H7,26,27,28,29,30,32,36,38,39,40,41,42);2-3,7-8H,4-5H2,1H3,(H,16,17)/b31-11+;/t12-,18-;7?,8-,10-/m10/s1 |
InChI Key: | GRHWKSLBMDQBQW-KZVOOCJBSA-N |
Structure link: | https://pubchem.ncbi.nlm.nih.gov/compound/86291594 |
External links: | |
Guide to Pharmacology: | ceftolozane |
Citations: |
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