Compound ID | 932

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Ecenofloxacin (CFC-222)

Class: Fluoroquinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Broad spectrum antibiotic which when tested against S. pneumonaie (penicillin -resistant, -intermediate and -susceptible) CFC-222, was more effective than ciprofloxacin, oflxacin, and lomefloxacin. It demonstrated similar activity to vancomycin and sparfloxacin.
Description: Kim JH, Kang JA, Hong KH, et al. IN vitro antibacterial activiy of CFC-222 against penicillin susceptible and -resistant Streptococcus pneumoniae. 35th-Intersci-Conf-Antimicrobial-Agents-Chemother 1995; 147.
Institute where first reported: CJ Corp., South Korea
Year first mentioned: 1995
Highest developmental phase: Phase 1
Development status: Inactive
Chemical structure(s):
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Molecular weight: 372.39
Iso. SMILES: C[C@@]12C[C@@H]([C@@H]1CN(C2)C3=C(C=C4C(=O)C(=CN(C4=N3)C5CC5)C(=O)O)F)N
InChI Key: WNVIWAUAXKEKKF-PJFSTRORSA-N
Can. SMILES: C[C@]12C[C@@H]([C@@H]2CN(C1)C3=NC4=C(C=C3F)C(=O)C(=CN4C5CC5)C(=O)O)N
InChI: InChI=1S/C19H21FN4O3/c1-19-5-14(21)12(19)7-23(8-19)17-13(20)4-10-15(25)11(18(26)27)6-24(9-2-3-9)16(10)22-17/h4,6,9,12,14H,2-3,5,7-8,21H2,1H3,(H,26,27)/t12-,14-,19-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/178066
Guide to Pharmacology: ecenofloxacin
Citations:
  • http://aac.asm.org/content/41/10/2209.short
  • https://journals.asm.org/doi/10.1128/aac.41.10.2209

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