Amifloxacin

Synonym(s): WIN 49375  |  WIN 49375-3

Class: Fluoroquinolone

Spectrum of activity:	Gram-positive
Institute where first reported:	Sanofi Winthrop (Sanofi Aventis, France); Yamanouchi Pharma. (Astellas Pharma., Japan)
Highest developmental phase:	Phase 2
Development status:	Inactive
Reason Dropped:	A number of frequent side effects: dizziness, gastrointestinal disorders, skin disorders and headaches

Chemical structure(s):
Canonical SMILES:	CNN1C=C(C(=O)C2=C1C=C(C(=C2)F)N3CCN(C)CC3)C(=O)O
Isomeric SMILES:	CNN1C=C(C(=O)C2=CC(=C(C=C21)N3CCN(CC3)C)F)C(=O)O
InChI:	InChI=1S/C16H19FN4O3/c1-18-21-9-11(16(23)24)15(22)10-7-12(17)14(8-13(10)21)20-5-3-19(2)4-6-20/h7-9,18H,3-6H2,1-2H3,(H,23,24)
InChI Key:	RUXPNBWPIRDVTH-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/55492

External links:
Guide to Pharmacology:	amifloxacin
Main Source:	https://journals.asm.org/doi/epdf/10.1128/aac.26.2.275