Compound ID | 940

Update compound information

Gatifloxacin

Class: Fluoroquinolone

Spectrum of activity: Gram-positive & Gram-negative
Details of activity: Gatifloxacin was developed as a broad spectrum antibiotic for a number of different infections including STIs, RTIs and eye disorders (3)
Description: Hori S, Kanemitsu K, Shimada J. Inhibitory activity of AM-1155, a newly synthesized quinolone, on gamma aminobutyric acid receptor binding. 32nd-ICAAC 1992;277
Institute where first reported: Allergan, UK; Kyorin Pharmaceutical, Japan; Senju Pharmaceutical, Japan; AbbVie
Year first mentioned: 1992
Highest development stage: Approved by FDA in 2010
Development status: Approved
Reason dropped: Other formulations discontinued from market due to hypo- and hyper- glycaemia (2)
Chemical structure(s):
Click here for structure editor
Molecular weight: 375.39
Iso. SMILES: CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F
InChI Key: XUBOMFCQGDBHNK-UHFFFAOYSA-N
Can. SMILES: CC1CN(CCN1)C2=C(C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(=O)O)OC
InChI: InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5379
Guide to Pharmacology: gatifloxacin
Citations:
  • http://adisinsight.springer.com/drugs/800001673
  • Http://www.merckmanuals.com/professional/infectious-diseases/bacteria-and-antibacterial-drugs/fluoroquinolones
  • https://journals.asm.org/doi/10.1128/aac.36.10.2108

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.