Compound ID | 954

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T-5575

Class: Beta-lactam (carboxypenam)

Spectrum of activity: Gram-negative
Details of activity: Potent antipseudomonal activity with a solely Gram negative spectrum. The compound is stable against a wide range of β-lactamases
Description: 1. Ochiai H, Murotani Y, Yamamoto H, et al. Novel parenteral 2-carboxypenas, T-5575 and T-5578. I. Synthesis and structure-activity relationships of 2-carboxypenam derivatives. 32nd-Intersci-Conf-Antimicrobial-Agents-Chemother 1992; 174 2. Watanabe Y, Minami S, Hayashi T, et al. Novel parenteral 2-carboxypenams, T-5575 and T-5578. II. In vitro and In vivo biological properties. 32nd-Intersci-Conf-Antimicrobial-Agents-Chemother 1992; 175
Institute where first reported: Toyama Chemical Co. Japan
Year first mentioned: 1992
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 660.52
Iso. SMILES: C1CN(C(=O)N1[C@@]2(CN3[C@H](S2)[C@@H](C3=O)NC(=O)[C@@H](C4=C(C=C(C=C4)O)F)S(=O)(=O)[O-])C(=O)[O-])/N=C/C=N/NC(=O)N.[Na+].[Na+]
InChI Key: NZZXKEOVCCUOOH-WPIYGBTHSA-L
Can. SMILES: C1=C(C=C(C(=C1)[C@H](C(=O)N[C@@H]2C(=O)N3C[C@@](C(=O)[O-])(N4CCN(C4=O)/N=C/C=N/NC(=O)N)S[C@H]23)S(=O)(=O)[O-])F)O.[Na+].[Na+]
InChI: InChI=1S/C20H21FN8O10S2.2Na/c21-11-7-9(30)1-2-10(11)13(41(37,38)39)14(31)25-12-15(32)27-8-20(17(33)34,40-16(12)27)28-5-6-29(19(28)36)24-4-3-23-26-18(22)35;;/h1-4,7,12-13,16,30H,5-6,8H2,(H,25,31)(H,33,34)(H3,22,26,35)(H,37,38,39);;/q;2*+1/p-2/b23-3+,24-4+;;/t12-,13-,16-,20-;;/m1../s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/11556538
Citation:

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