Compound ID | 955

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T-5578

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Cell wall synthesis inhibitor. Stable to a wide range of beta-lactamases
Target Pathogen: Active against Pseudomonas aeruginosa
Description: A carboxypenam; 1. Ochiai H, Murotani Y, Yamamoto H, et al. Novel parenteral 2-carboxypenas, T-5575 and T-5578. I. Synthesis and structure-activity relationships of 2-carboxypenam derivatives. 32nd-Intersci-Conf-Antimicrobial-Agents-Chemother 1992; 174 2. Watanabe Y, Minami S, Hayashi T, et al. Novel parenteral 2-carboxypenams, T-5575 and T-5578. II. In vitro and In vivo biological properties. 32nd-Intersci-Conf-Antimicrobial-Agents-Chemother 1992; 175
Institute where first reported: Toyama Chemical Co. Japan
Year first mentioned: 1992
Highest development stage: Preclinical
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 605.49
Iso. SMILES: C1CN(C(=O)N1[C@@]2(CN3[C@H](S2)[C@@H](C3=O)NC(=O)[C@@H](C4=C(C=C(C=C4)O)F)S(=O)(=O)[O-])C(=O)[O-])N=C(N)N.[Na+].[Na+]
InChI Key: TUVNTOWBSHLERO-DDFPHNIFSA-L
Can. SMILES: C1=C(C=C(C(=C1)[C@H](C(=O)N[C@@H]2C(=O)N3C[C@@](C(=O)[O-])(N4CCN(C4=O)N=C(N)N)S[C@H]23)S(=O)(=O)[O-])F)O.[Na+].[Na+]
InChI: InChI=1S/C18H20FN7O9S2.2Na/c19-9-5-7(27)1-2-8(9)11(37(33,34)35)12(28)22-10-13(29)24-6-18(15(30)31,36-14(10)24)25-3-4-26(17(25)32)23-16(20)21;;/h1-2,5,10-11,14,27H,3-4,6H2,(H,22,28)(H,30,31)(H4,20,21,23)(H,33,34,35);;/q;2*+1/p-2/t10-,11-,14-,18-;;/m1../s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/129651151

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