Compound ID | 959

Update compound information

Ro 481220

Class: Beta-lactamase inhibitor (penicillanic acid sulfone)

Details of activity: When administered with a β-lactam such as apalcillin or pipercillin, demonstrated a lower MIC than tazobactam with pipercillin
Description: Angehrn P, Cullmann W, Hohl P, et al. In vitro activity of combinations of β-lactamase inhibitor Ro 481220. 34th-Intersci-Conf-Antimicrobial-Agents-Chemother 1994; 203.
Institute where first reported: Hoffmann-La Roche Inc, Switzerland
Year first mentioned: 1994
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
Click here for structure editor
Molecular weight: 292.25
Iso. SMILES: C[C@@]1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)[O-])/C=C/C#N.[Na+]
InChI Key: DRNHQKOSAXWVCX-LSTOSFGNSA-M
Can. SMILES: C[C@]1(/C=C/C#N)[C@H](C(=O)[O-])N2C(=O)C[C@H]2S1(=O)=O.[Na+]
InChI: InChI=1S/C10H10N2O5S.Na/c1-10(3-2-4-11)8(9(14)15)12-6(13)5-7(12)18(10,16)17;/h2-3,7-8H,5H2,1H3,(H,14,15);/q;+1/p-1/b3-2+;/t7-,8+,10+;/m1./s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/44264235
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC163734/

  • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.