Compound ID | 965

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BLI-489

Class: Beta-lactamase inhibitor (carbapenem)

Details of activity: β-lactamase inhibitor, inhibits class A, C and D β-lactamases
Combined with other compounds: Was tested with pipercillin in murine modelswhich demonstrated a similar level of efficacy as pipercillin:tazobactam
Institute where first reported: Wyeth Research (Pfizer, USA)
Year first mentioned: 2007
Highest developmental phase: Phase 1
Development status: Inactive
Reason Dropped: Was in phase I trials with Wyeth, however, with Pfizer (purchased Wyeth in 2009) closed it's antibioitc research unit in 2011 (1,2).
Chemical structure(s):
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Molecular weight: 327.29
Iso. SMILES: C1COCC2=NC(=CN21)/C=C/3\[C@@H]4N(C3=O)C(=CS4)C(=O)[O-].[Na+]
InChI Key: RFSWVJXWZXQOSW-ZDFSRXSCSA-M
Can. SMILES: C1COCC2=NC(=CN12)/C=C\3/C(=O)N4C(=CS[C@H]34)C(=O)[O-].[Na+]
InChI: InChI=1S/C13H11N3O4S.Na/c17-11-8(12-16(11)9(6-21-12)13(18)19)3-7-4-15-1-2-20-5-10(15)14-7;/h3-4,6,12H,1-2,5H2,(H,18,19);/q;+1/p-1/b8-3-;/t12-;/m1./s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/23697683
Guide to Pharmacology: BLI-489 free acid
Citations:
  • http://aac.asm.org/content/53/2/370.short#fn-2
  • https://clinicaltrials.gov/ct2/show/NCT00894439

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