Compound ID | 99

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ABEPI 2

Class: Drug efflux pump inhibitor

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Efflux pump inhibitor. Serum-associated antibiotic efflux pump inhibitor
Target Pathogen: Active against Acinetobacter baumannii
Combined with other compounds: Yes
Description: Potentiates antibiotics
Institute where first reported: Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Year first mentioned: 2014
Development status: Experimental
Chemical structure(s):
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Molecular weight: 271.38
Iso. SMILES: CC(C)(C)NC(=O)CSC1=NN=NN1C(C)(C)C
InChI Key: ZBUXBTJXIPQCGO-UHFFFAOYSA-N
Can. SMILES: CC(C)(C)NC(=O)CSC1=NN=NN1C(C)(C)C
InChI: InChI=1S/C11H21N5OS/c1-10(2,3)12-8(17)7-18-9-13-14-15-16(9)11(4,5)6/h7H2,1-6H3,(H,12,17)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/714079
Citations:
  • https://www.ncbi.nlm.nih.gov/pubmed/25114126
  • https://journals.asm.org/doi/10.1128/aac.03535-14
    • Patent: CA2952111C

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