Development status: Approved, off-patent

Gram-positive activity

Gram-negative activity

Mechanism of Action/Target pathogen: Inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome. Active against Gram-positive and Gram-negative bacteria, especially Pseudomonas aeruginosa

Additional information: Streptomyces natural product. Veterinary use, human use primarily in combination therapy in Pseudomonas infections as inhaled therapy in Cystic Fibrosis patients