Development status: Approved, off-patent

Gram-positive activity

Gram-negative activity

Mechanism of Action/Target pathogen: Binds to bacterial penicillin-binding proteins (PBP) and interferes with bacterial cell wall integrity and synthesis. Active against some Enterobacteriaceae and Pseudomonas aeruginosa but high resistance rates

Additional information: Semisynthetic Cephalosporine, derived from Cephalosporin C. Fixed combination with sulbactam available in some countries