Development status: Approved, off-patent

Gram-positive activity

Gram-negative activity

Mechanism of Action/Target pathogen: Binds to bacterial penicillin-binding proteins (PBP) and interferes with bacterial cell wall integrity and synthesis. Active against Gram-positive bacteria and some Enterobacteriaceae, but vulnerable to penicillinases produced by staphylococci and E. coli

Additional information: Semisynthetic penicillin, derived from 6-aminopenicillanic acid (6-APA). Oral and parenteral application. Most used antibiotic globally.