Development status: Discontinued

Gram-positive activity

Mechanism of Action/Target pathogen: Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.

Additional information: Synthetic compound; active compound of prontosil; para-aminobenzoic acid (PABA) analogue. Topical use.