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Table of all 3513 compounds in AntibioticDB

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ADB ID Drug Name Drug Class Year Developmental Phase
1 Acyldepsipeptide 4 (ADEP4) Acyldepsipeptide 2013 Preclinical
2 FY-901 Aminoglycoside 2012 Preclinical
4 Plazomicin (Zemdri) Aminoglycoside 2012 Approved
6 AVP-21D9 (Thravixa) Antibody 2011 Phase 1 (NCT01202695)
7 MEDI3902 Antibody 2014 Phase 2 (NCT04631016)
8 Suvratoxumab, MEDI4893, LC-10 Antibody 2012 Phase 3 (NCT05331885)
9 OH-CATH30 Antimicrobial peptide 2012 Preclinical
10 AA-139 (Arenicin) Antimicrobial peptide 2013 Preclinical
11 Anuran Trypsin Inhibitory Peptide SLF1 Experimental 2015 Preclinical
12 Anuran Trypsin Inhibitory Peptide SLF2 Antimicrobial peptide 2015 Preclinical
13 Anuran Trypsin Inhibitory Peptide SLF3 Antimicrobial peptide 2015 Preclinical
14 Anuran Trypsin Inhibitory Peptide SLF4 Antimicrobial peptide 2015 Preclinical
15 Anuran Trypsin Inhibitory Peptide SLF5 Antimicrobial peptide 2015 Preclinical
16 Bacteriocin LU11 Antimicrobial peptide 2014 Preclinical
17 BR003-cecropin A Antimicrobial peptide 2012 Preclinical
18 Clavanin A Antimicrobial peptide 2003 Preclinical
19 Dipeptidomimetic Compound 1a Antimicrobial peptide 2003 Preclinical
20 Dipeptidomimetic Compound 1b Antimicrobial peptide 2014 Preclinical
21 Dipeptidomimetic Compound 1c Antimicrobial peptide 2014 Preclinical
22 Dipeptidomimetic Compound 1d Antimicrobial peptide 2014 Preclinical
23 Dipeptidomimetic Compound 1e Antimicrobial peptide 2014 Preclinical
24 Dipeptidomimetic Compound 1f Antimicrobial peptide 2014 Preclinical
25 Dipeptidomimetic Compound 2a Antimicrobial peptide 2014 Preclinical
26 Dipeptidomimetic Compound 2b Antimicrobial peptide 2014 Preclinical
27 Dipeptidomimetic Compound 2c Antimicrobial peptide 2014 Preclinical
28 Dipeptidomimetic Compound 2d Antimicrobial peptide 2014 Preclinical
29 Dipeptidomimetic Compound 2e Antimicrobial peptide 2014 Preclinical
30 Dipeptidomimetic Compound 2f Antimicrobial peptide 2014 Preclinical
31 DP7 Antimicrobial peptide 2014 Preclinical
32 eCATH1 Antimicrobial peptide 2012 Preclinical
33 Epinecidin-1 Antimicrobial peptide 2006 Preclinical
34 G3KL Antimicrobial peptide 2014 Preclinical
35 hBD-1 Antimicrobial peptide 1999 Preclinical
36 hBD-2 Antimicrobial peptide 1999 Preclinical
37 Lycosin 1 Antimicrobial peptide 2012 Preclinical
38 Myxinidin Antimicrobial peptide 2009 Preclinical
39 NAI-603 Glycolipodepsipeptide 2014 Preclinical
40 Pumicin NI04 Antimicrobial peptide 2015 Preclinical
41 Pardaxin (GE33) Antimicrobial peptide 2013 Preclinical
42 Peptide 1018 Antimicrobial peptide 2012 Preclinical
43 Kocurin Antimicrobial peptide 2013 Preclinical
44 Protonectin Antimicrobial peptide 1993 Preclinical
45 PXL150 Antimicrobial peptide 2013 Preclinical
46 RRIKA Antimicrobial peptide 2014 Preclinical
47 RR Antimicrobial peptide 2014 Preclinical
48 SASPject3.1 Antimicrobial peptide 2014 Preclinical
49 SASPject4 Antimicrobial peptide 2014 Preclinical
50 Temporin A Antimicrobial peptide 2000 Preclinical
51 Temporin B Antimicrobial peptide 2000 Preclinical
52 TP10 (transportan-10) Antimicrobial peptide 2003 Preclinical
53 Tripropeptin C Antimicrobial peptide (tripropeptin lipodepsipeptide) 2001 Preclinical
54 Xenohagxin Antimicrobial peptide 2014 Preclinical
55 LTX-109 Antimicrobial peptidomimetic 2008 Phase 2
56 Pexiganan Antimicrobial peptide 1998 Phase 3
57 WR12 Antimicrobial peptide 2015 Preclinical
58 WLBU2 Antimicrobial peptide 2006 Preclinical
59 Subtilosin Antimicrobial peptide 1985 Preclinical
60 AS10 Antimicrobial peptide 2014 Preclinical
61 Dermaseptin S4 derivative: K4-K20-S4 Antimicrobial peptide 2001 Preclinical
62 R-thanatin Antimicrobial peptide 2013 Preclinical
63 GL13K Antimicrobial peptide 2011 Preclinical
64 AP138 (Plectasin) Antimicrobial peptide 2004 Preclinical
65 NAI-107, microbisporicin Antimicrobial peptide (lantibiotic) 2009 Preclinical
66 P10/P60.4Ac Antimicrobial peptide (LL-37 derivative) 2014 Preclinical
67 Streptomyces papain inhibitor [SPI] Antimicrobial peptide (papain inhibitory protein) 2011 Preclinical
68 SASPject1.2 Bacteriophage 2014 Phase 1
69 ClyH Bacteriophage lysin 2014 Preclinical
70 HY-133 Bacteriophage lysin 2011 Preclinical
71 PRF-119 Bacteriophage lysin 2011 Preclinical
72 Ply187AN-KSH3b Bacteriophage lysin 2014 Preclinical
73 PlyF307 Bacteriophage lysin 2015 Preclinical
74 PlyPy Bacteriophage lysin 2014 Preclinical
75 PlySK1249 Bacteriophage lysin 2013 Preclinical
76 PlySs2 Bacteriophage lysin 2013 Preclinical
77 SAL200 Bacteriophage lysin 2013 Phase 2 (NCT05329168)
78 Art-175 Bacteriophage lysin (artilysins) 2014 Preclinical
79 Cefepime + enmetazobactam (Exblifep) Beta-lactam (cephalosporin, fourth generation) + beta-lactamase inhibitor (penicillanic acid sulfone) 2015 Approved by FDA in 2024
80 MG96077 Beta-lactamase inhibitor 2009 Preclinical
83 EDP-788 Macrolide (bicyclic macrolide) 2013 Phase 1 (NCT02255968)
84 FSI-1671 Beta-lactam (carbapenem) 2014 Preclinical
85 FSI-1686 Beta-lactam (carbapenem) 2014 Preclinical
86 Imipenem + cilastatin/relebactam Drug combination: beta-lactam (carbapenem) + beta-lactamase inhibitor (non-beta-lactam beta-lactamase inhibitor, diazabicyclooctane [DBO]) 2011 Approved by FDA in 2019
87 OSU-03012 (AR-12) Celecoxib-derived antibacterial inhibitor 2009 Preclinical
88 CB-027 Beta-lactam (cephalosporin) 2013 Preclinical
89 S201 Beta-lactam (cephalosporin) 2014 Preclinical
90 Cefiderocol (Fetroja) Beta-lactam (cephalosporin) 2013 Approved by FDA in 2019
91 Ceftobiprole (active moiety of ceftobiprole medocaril) Beta-lactam (cephalosporin) 2002 Approved by FDA in 2024
92 Avycaz/Zavicefta (Ceftazidime/Avibactam) Drug combination: beta-lactam (cephalosporin) + beta-lactamase inhibitor 2005 Approved by FDA in 2015
93 Ceftolozane + tazobactam (Zerbaxa) Drug combination: beta-lactam (cephalosporin, fourth generation) + beta-lactamase inhibitor (penicillanic acid sulfone) 2012 Approved by FDA in 2014
94 1-O-methyl-NBD-ceramide-C16 Antichlamydial ceramide 2014 Preclinical
95 DAV131 Activated charcoal, absorbant 2013
96 Brilacidin Antimicrobial peptide (defensin mimetic) 2012/13 Phase 2 (NCT02052388)
98 ABEPI 1 Efflux pump inhibitor 2014 Preclinical
99 ABEPI 2 Efflux pump inhibitor 2014 Preclinical
100 Zempia (E-101) Antiseptic 2008 Phase 3 (NCT01297959)
101 Lysostaphin Zinc metalloprotease (glycyl-glycine endopeptidase) 1964
103 Benzimidazole-Based FABI inhibitor 1 Fatty acid synthesis inhibitor (FabI inhibitor) 2014
104 Benzimidazole-Based FABI inhibitor 2 Fatty acid synthesis inhibitor (FabI inhibitor) 2014
105 Benzimidazole-Based FABI inhibitor 3 Fatty acid synthesis inhibitor (FabI inhibitor) 2014
106 Benzimidazole-Based FABI inhibitor 4 Fatty acid synthesis inhibitor (FabI inhibitor) 2014
107 Benzimidazole-Based FABI inhibitor 5 Fatty acid synthesis inhibitor (FabI inhibitor) 2014
108 Benzimidazole-Based FABI inhibitor 6 Fatty acid synthesis inhibitor (FabI inhibitor) 2014
109 Benzimidazole-Based FABI inhibitor 7 Fatty acid synthesis inhibitor (FabI inhibitor) 2014
110 Benzimidazole-Based FABI inhibitor 8 Fatty acid synthesis inhibitor (FabI inhibitor) 2014
111 Benzimidazole-Based FABI inhibitor 9 Fatty acid synthesis inhibitor (FabI inhibitor) 2014
112 Benzimidazole-Based FABI inhibitor 10 Fatty acid synthesis inhibitor (FabI inhibitor) 2014
113 PT52 (Diphenyl ether) Fatty acid synthesis inhibitor (FabI inhibitor) 2013
114 PT68 (Diphenyl ether) Fatty acid synthesis inhibitor (FabI inhibitor) 2013
115 VT-02-00068 Fatty acid synthesis inhibitor (FabI inhibitor) 2014
116 FAB001 Fatty acid synthesis inhibitor (FabI inhibitor) 2009 Phase 1
117 Nilofabicin Fatty acid synthesis inhibitor (FabI inhibitor) 2006 Phase 2 (NCT01593761)
118 Afabicin dephosphono Fatty acid synthesis inhibitor (FabI inhibitor) 2014 Phase 2 (NCT03723551)
119 cis-6-hexadecenoic acid (C6H) Human skin fatty acid 2014
122 Delafloxacin Fluoroquinolone 2009 (phase 2 trials) Approved by FDA in 2017
123 WCK771 Fluoroquinolone 2001 Phase 3 (NCT03405064)
124 Alalevonadifloxacin Fluoroquinolone 2001 Phase 1 (NCT04874324)
125 Zabofloxacin Fluoroquinolone 2003 Phase 3 (NCT01658020)
126 MBX-500 Fluoroquinolone 2012 Preclinical
127 Oxantel Fumarate reductase inhibitor 1975 Preclinical
128 Fusidic acid Fusidane 2010 Phase 3
129 Vcn-PF (Vancomycin derivative) Glycopeptide unknown Preclinical
130 Vcn-A (Vancomycin derivative) Glycopeptide unknown Preclinical
131 Vcn-B (Vancomycin derivative) Glycopeptide unknown Preclinical
132 Oritavancin (Orbactiv) Glycopeptide 1996 Approved by FDA in 2014
133 TD-1607 Glycopeptide-cephalosporin heterodimer 2010 Phase 1 (NCT01949103)
134 Ramoplanin Glycolipodepsipeptide 2003 Phase 2
135 Dalbavancin (Dalvance) Glycolipodepsipeptide 2001 Approved by FDA in 2014
136 GP-2 Bacterial topoisomerase inhibitor 2013 Preclinical
137 GP-4 Bacterial topoisomerase inhibitor 2014 Preclinical
138 2,3-Dihydroxybenzoic Acid (DHBA) Antibiofilm agent (iron chelator) 1986 Preclinical
139 ACH-702 Isothiazoloquinolone 2008 Preclinical
140 Nafithromycin Macrolide (16-membered macrolide, ketolide) 2013 Phase 2
141 Liamocin Oil dervatives Liamocin oil 2014 Preclinical
142 Surotomycin, CB-183,315 Lipopeptide 2011 Phase 3
143 ACHN-975 Lipopolysaccharide synthesis inhibitor (LpxC inhibitor) 2012 Phase 1
144 Murepavadin Lipopolysaccharide synthesis inhibitor (LptD inhibitor) 2008 Phase 3 (NCT03582007)
145 RBx 14255 Macrolide (16-membered macrolide, fluoroketolide) 2012 Preclinical
146 Solithromycin Macrolide (16-membered macrolide, fluoroketolide) 2008 Phase 3
147 MB-1 Beta-lactam (siderophore-monobactam conjugate) 2015 Preclinical
148 Meropenem + Vaborbactam Beta-lactam (carbapenem) + beta-lactamase inhibitor (heterocyclic boron) 2013 Approved by FDA in 2017
149 CRS3123 Aminoacyl-tRNA synthetase inhibitor (methionyl tRNA synthetase [MetRS] inhibitor) 2007 Phase 2 (NCT04781387)
150 Aztreonam + Avibactam Beta-lactam (monobactam) + beta-lactamase inhibitor (non-beta-lactam beta-lactamase inhibitor, diazabicyclooctane [DBO]) 2012 Phase 3 (NCT03329092)
151 BAL30072 Beta-lactam (siderophore-sulfactam) 2008 Phase 1
152 AiiA AuNPs (gold nano particles) Nanoparticles (gold) in combination with lactonase Preclinical
153 CAL02 Nanoparticles (liposomes) 2013 Phase 2 (NCT05776004)
154 AgNP (silver nanoparticles) Nanoparticles (silver) citrate capped Preclinical
155 Amixicile Antibiofilm agent (nitazoxanide derivative) 2012 Preclinical
156 Glyceryl Trinitrate (GTN)/Citrate/Ethanol (CAP) (GTN-CAP) Antibiofilm agent 2013 Preclinical
157 Ozenoxacin Quinolone 2007 Approved by FDA in 2017
158 Nemonoxacin Quinolone 2007
159 SQ641 MraY inhibitor 1986 Preclinical
160 Colostrum Hexasaccharide Quorum-sensing inhibitor 1976 (for compound) 2015 (for research) Preclinical
161 IMT504 Immunomodulator 2005 Preclinical
162 Surgihoney™ (SH) Bioengineered honey 2015 Preclinical
163 MRX-II Oxazolidinone 2015 Preclinical
164 Delpazolid (LCB01-0371) Oxazolidinone 2010 Phase 2 (NCT05225558; NCT06004037)
165 Contezolid (MRX-4/MRX-1) Oxazolidinone 2014 Phase 3 (NCT06081361)
167 Tedizolid (Sivextro) Oxazolidinone 2007 Approved by FDA in 2014
168 F2Pal Immunomodulator (pepducin class) 2010 Preclinical
169 PLNA787 Peptide-locked nucleic acid 2015 Preclinical
170 Ceragenins (CSA-131) Peptidomimetic 2015 Preclinical
171 MBX 1641 Antivirulence agent (T3SS inhibitor) 2014 Preclinical
172 BC-7641 Pleuromutilin 2010 Preclinical
173 BC-9074 Pleuromutilin 2010 Preclinical
174 BC-9077 Pleuromutilin 2010 Preclinical
175 BC-9505 Pleuromutilin 2010 Preclinical
176 BC-9514 Pleuromutilin 2010 Preclinical
177 BC-9520 Pleuromutilin 2010 Preclinical
178 BC-9529 Pleuromutilin 2010 Preclinical
179 BC-9538 Pleuromutilin 2010 Preclinical
180 BC-9539 Pleuromutilin 2010 Preclinical
181 BC-9540 Pleuromutilin 2010 Preclinical
182 BC-9543 Pleuromutilin 2010 Preclinical
183 BC-9545 Pleuromutilin 2010 Preclinical
184 BC-9556 Pleuromutilin 2010 Preclinical
185 BC-9561 Pleuromutilin 2010 Preclinical
186 Lefamulin Pleuromutilin 2010 Approved by FDA in 2019
187 Lefamulin (BC-3781) Pleuromutilin 2011 Approved by FDA in 2019
188 ω-Hydroxyemodin Quorum-sensing inhibitor 2015 Preclinical
189 Dextrin-colistin polymer conjugate Polymyxin-polymer conjugate 2014 Preclinical
190 NAB739 Polymyxin-polymer conjugate 2008 Preclinical
191 G2cps Inhibitor of biofilm formation 2013 Preclinical
192 MBX 2319, MBX2319, MBX-2319 Efflux pump inhibitor 2013 Preclinical
193 LolCDE Inhibitor 10 LolCDE ABC transporter inhibitor 2014 Preclinical
194 RX-P873 Protein synthesis inhibitor (pyrrolocytosine series) 2015 Preclinical
195 Lascufloxacin Fluoroquinolone 2013
196 Cadazolid Quinolonyl-oxazolidinone 2012 Phase 3
197 QSi413 Quorum sensing inhibitor 2014 Preclinical
198 QSi129 Quorum sensing inhibitor 2014 Preclinical
199 QSi303 Quorum sensing inhibitor 2014 Preclinical
200 Aptamer Antagonist A11 Antivirulence agent 2015 Preclinical
202 DNAC-1 Quinolinol derivative 2015 Preclinical
203 HPi1 3-hydrazinoquinoxaline-2-thiol 2014 Preclinical
204 PT-8420 and PT-8541 Lethal factor protease inhibitor 2013 Preclinical
206 MAC-0170636 Cell-wall synthesis inhibitor 2014 Preclinical
207 MAC-0174466 Cell-wall synthesis inhibitor 2014 Preclinical
208 MAC-0080655 Cell-wall synthesis inhibitor 2014 Preclinical
209 MAC-0177727 Cell-wall synthesis inhibitor 2014 Preclinical
210 MAC-0020108 Cell-wall synthesis inhibitor 2014 Preclinical
211 MAC-0020111 Cell-wall synthesis inhibitor 2014 Preclinical
212 MAC-0026022 Cell-wall synthesis inhibitor 2014 Preclinical
213 MAC-0042770 Cell-wall synthesis inhibitor 2014 Preclinical
214 MAC-0045389 Cell-wall synthesis inhibitor 2014 Preclinical
215 RNPA 1000 RnpA inhibitor 2011 Preclinical
216 RNPA 2000 RnpA inhibitor 2011 Preclinical
217 Ridinilazole DNA minor groove binder 2011 Phase 3
218 N-Chlorotaurine (NCT) Antiseptic 1998 Preclinical
219 PC190723 FtsZ inhibitor 2008 Preclinical
220 Menadione Menaquinone analogue 2013 Preclinical
221 1,4-Naphthoquinone Menaquinone analogue 2013 Preclinical
222 Menaquinolone Analogue: Coenzyme Q1 Menaquinone analogue 2013 Preclinical
223 Menaquinolone Analogue: Coenzyme Q2 Menaquinone analogue 2013 Preclinical
224 Menaquinolone Analogue: Coenzyme Q3 Menaquinone analogue 2013 Preclinical
225 Q24DA (Quinazoline-2,4-Diamino Analogue) Antivirulence agent 2011 Preclinical
226 DS-96 Vaginal microbicide 2008 Preclinical
227 CL-55 Antivirulence agent (T3SS inhibitor) 2015 Phase 2 (NCT03638830)
228 KS100 Antivirulence agent (T6SS inhibitor) 2014 Preclinical
229 KS200 Antivirulence agent (T6SS inhibitor) 2014 Preclinical
230 KKL-35 Trans-translation inhibitor 2013 Preclinical
231 Pyridodiazepine amine compound A MurI inhibitor 2014 Preclinical
232 C11 Quorum sensing inhibitor 2015 Preclinical
233 RX-04A Protein synthesis inhibitor (pyrrolocytosine) 2015 Preclinical
234 RX-04B Protein synthesis inhibitor (pyrrolocytosine) 2015 Preclinical
235 RX-04C Protein synthesis inhibitor (pyrrolocytosine) 2015 Preclinical
236 RX-04D Protein synthesis inhibitor (pyrrolocytosine) 2015 Preclinical
237 Compound 7955004 Adenosine mimetic 2015 Preclinical
238 Teixobactin Cell-wall synthesis inhibitor (lipid II inhibitor) 2015 Preclinical
239 BAS00127538 Cell-wall synthesis inhibitor (lipid II inhibitor) 2013 Preclinical
240 GPI0363 RNA synthesis inhibitor 2014 Preclinical
241 TP-076 Tetracycline 2014 Phase 1
242 TP-138 Tetracycline 2014 Preclinical
243 TP-600 Tetracycline 2014 Preclinical
245 Eravacycline (Xerava) Tetracycline 2012 Approved by FDA in 2018
246 Omadacycline (Nuzyra) Tetracycline 2006 Approved by FDA in 2018
247 Thiazomycin Thiazolyl peptide 2007 Preclinical
248 NxtSc-G5 2014 Preclinical
249 Benzothiazole Ethyl Urea Inhibitor Compound A Bacterial topoisomerase inhibitor 2013 Preclinical
250 Benzothiazole Ethyl Urea Inhibitor Compound B Bacterial topoisomerase inhibitor 2013 Preclinical
251 Kibdelomycin Bacterial topoisomerase inhibitor 2011 Preclinical
252 NBTI 5463 Bacterial topoisomerase inhibitor 2014 Preclinical
253 Gepotidacin Bacterial topoisomerase inhibitor 2011 Phase 3
254 Amycolamicin Bacterial topoisomerase inhibitor 2010 Preclinical
255 Cytosporone B derivative Antivirulence agent 2010/2013 Preclinical
256 SRI-20864 Dihydrofolate reductase inhibitor 2004 Preclinical
257 SRI-20920 Dihydrofolate reductase inhibitor 2004 Preclinical
258 Research Program: (259C) 6-anilinouracil-fluoroquinolone hybrid 2003 Preclinical
259 SRI 9581 Ababinose dissacharide analogue 2000 Preclinical
260 FMA 1082 Acylide 2003
261 OPT-382 Aminoglycoside 2003 Preclinical
262 TS2037 (derivative of arbekicin) Aminoglycoside 2004
263 Vancomyquine (PA1409) Aminoquinoline-glycopeptide hybride 2009 Preclinical
265 IT-62-B Anthracycline 1995 Preclinical
266 Altromycin B DNA minor groove binder 1989 Preclinical
267 VIC-104988 Oxazolidinone (azabicyclic analogue) 2005 Preclinical
268 L-701,103 Macrolide (15-membered macrolide) 1993 Preclinical
269 L-701,677 Macrolide (15-membered macrolide) 1993 Preclinical
270 L-708,299 Macrolide (15-membered macrolide) 1993 Preclinical
271 L-708,365 Macrolide (15-membered macrolide) 1993 Preclinical
273 5-Deoxyenterocin Antimicrobial peptide (bacteriocin) 1986 Preclinical
274 BAS-118 Benzamide 2001 Preclinical
275 RP60556A Benzo[b]naphthyridone 2000 Preclinical
276 PD-0162819 Biotin carboxylase inhibitor 2009 Preclinical
278 MBX1162 Bis-indole 2009 Preclinical
279 MBX1090 Bis-indole 2009 Preclinical
280 MBX1113 Bis-indole 2009 Preclinical
281 MBX1128 Bis-indole 2009 Preclinical
282 A358 Sulfa drug / Sulphonamide 2001 Preclinical
283 AN0128 Borinic acid ester 2005 Phase 2
284 PMX100 Calixarene 2010 Preclinical
285 PMX223 Calixarene 2010 Preclinical
286 PMX243 Calixarene 2010 Preclinical
287 BMS 181139 Beta-lactam (carbapenem) 1994 Preclinical
288 BO-3482 Beta-lactam (carbapenem) 1996 Preclinical
289 CL 188624 Beta-lactam (carbapenem) 1994 Preclinical
290 CL 191121 Beta-lactam (carbapenem) 1994 Preclinical
291 DU 6681 Beta-lactam (carbapenem) 1995 Preclinical
293 DX-8739 Beta-lactam (carbapenem) 1992 Preclinical
294 FR 21818 Beta-lactam (carbapenem) 1995 Preclinical
295 J-111,225 Beta-lactam (carbapenem) 1998 Preclinical
296 J-114,871 Beta-lactam (carbapenem) 1998 Preclinical
297 J-114,870 Beta-lactam (carbapenem) 1998 Preclinical
298 KR-21012 Beta-lactam (carbapenem) 1998 Preclinical
299 L-695256 Beta-lactam (carbapenem) 1994 Preclinical
300 L-786392 Beta-lactam (carbapenem) 1998 Preclinical
301 Lenapenem (Bo- 2727) Beta-lactam (carbapenem) 1990 Phase 2
302 Saccharomicin A Antimicrobial peptide (heptadecaglycoside) 1999 Preclinical
303 Saccharomicin B Antimicrobial peptide (heptadecaglycoside) 1999 Preclinical
304 LICA/WRAIR Membrane-active agent (chalcone) 1999 Preclinical
305 Epidermicin NI01 Antimicrobial peptide 2010 Preclinical
306 Guanacastepene Membrane-active agent 1998 Preclinical
307 CA(1-8)M(1-18) Antimicrobial peptide 1999 Preclinical
308 Lactoferricin B (bovine) Antimicrobial peptide 1999 Preclinical
309 Cecropin P1 Antimicrobial peptide 1998 Preclinical
310 LY264826 (A82846B) Glycopeptide 1995 Preclinical
311 LY307599 Glycopeptide 1997 Preclinical
312 PGE-956 7567 Cell-wall synthesis inhibitor (biarylamide) 1999 Preclinical
313 BP-102 Beta-lactam (cephalosporin, carbacephem) 2005 Preclinical
314 CP-5068 Beta-lactam (carbapenem) 2000 Preclinical
315 ME1036 (CP5609) Beta-lactam (carbapenem) 2003 Preclinical
316 P-91022 Beta-lactam (carbapenem) 2004 Preclinical
317 P-21028 Beta-lactam (carbapenem) 2004 Preclinical
318 Research Programme-2-(Thiazol-2ylthio)-1β-Methylcarbapenem: SM-197436 Beta-lactam (carbapenem) 2001 Preclinical
319 Research Programme-2-(Thiazol-2ylthio)-1β-Methylcarbapenem: SM-232721 Beta-lactam (carbapenem) 2001 Preclinical
320 Research Programme-2-(Thiazol-2ylthio)-1β-Methylcarbapenem: SM-232724 Beta-lactam (carbapenem) 2001 Preclinical
321 Tomopenem Beta-lactam (carbapenem) 2000 Phase 2
322 BMS-195059 Beta-lactam (cephalosporin) 2000
323 BMS-217441 Beta-lactam (cephalosporin) 2000
324 BC-2901 Beta-lactam (cephalosporin) 2005 Preclinical
325 BMS-247243 Beta-lactam (cephalosporin) 2000 Preclinical
326 BMS-28232 Beta-lactam (cephalosporin) 1987 Preclinical
327 BO-1341 Beta-lactam (cephalosporin) 1987 Preclinical
329 CP6162 Beta-lactam (cephalosporin) 1989 Preclinical
330 L-658,310 (BO1236) Beta-lactam (cephalosporin) 1987 Preclinical
331 LB 11058 Beta-lactam (cephalosporin) 2002 Preclinical
332 LY193239 (methyl-sulfanato at C-3 version of LY173013) Beta-lactam (cephalosporin) 1987 Preclinical
333 ME1220 Beta-lactam (cephalosporin) 1986 Preclinical
334 ME1221 Beta-lactam (cephalosporin) 1986 Preclinical
335 NB2001 Beta-lactam (cephalosporin) 2001 Preclinical
336 OCP 9-176 Beta-lactam (cephalosporin) 1987 Preclinical
337 PGE 6737410 Beta-lactam (cephalosporin) 2000 Preclinical
338 PGE 856854 Beta-lactam (cephalosporin) 2000 Preclinical
339 PGE 9739390 Beta-lactam (cephalosporin) 2000 Preclinical
340 PGE 9882816 Beta-lactam (cephalosporin) 2000 Preclinical
341 PGE 9951357 Beta-lactam (cephalosporin) 2000 Preclinical
342 RWJ-333441 Beta-lactam (cephalosporin) 2000 Preclinical
343 RWJ 333442 (Prodrug of RWJ-333441) Beta-lactam (cephalosporin) 2000 Preclinical
345 RWJ-442831 (Prodrug of RWJ-54428) Beta-lactam (cephalosporin) 2000 Preclinical
346 SR 44337 Beta-lactam (cephalosporin) 1989 Preclinical
347 YJP-40102 Beta-lactam (cephalosporin) 2005 Preclinical
348 Cefetecol (GR69153) Beta-lactam (cephalosporin) 1989 Phase 1
350 FK518 Beta-lactam (cephalosporin) 1990 Phase 1
351 HR 916B (Prodrug of RU29246) Beta-lactam (cephalosporin) 1991 Phase 1
352 M14659 (GR 63116) Beta-lactam (cephalosporin) 1986 Phase 1
354 RU29246 (Orally active version of HR916) Beta-lactam (cephalosporin) 1990 Phase 1
355 Cefclidine Beta-lactam (cephalosporin) 1987 Phase 2
356 ME1228 (sulphur analogue of OCP9176) Beta-lactam (cephalosporin) 1987 Phase 2
357 Cefluprenam Beta-lactam (cephalosporin) 1991 Phase 3
358 Ceftizoxime alapivoxil (prodrug) Beta-lactam (cephalosporin) 1983 Approved by FDA in 1983
359 CM 40876 Beta-lactam (cephalosporin) 1986
360 KP-736 Beta-lactam (cephalosporin) 1989 Phase 2/3
361 BMS-234138 Beta-lactam (cephalosporin) 2000
362 DQ-2556 Beta-lactam (cephalosporin) 1988
363 RU 45978 (isocephem of RU 46069) Beta-lactam (cephalosporin) 1988
364 RU 46069 (isocephem of RU 45978) Beta-lactam (cephalosporin) 1988
365 SPD 135 Beta-lactam (cephalosporin) 1990
366 YM-22561 (YM561) Beta-lactam (cephalosporin) 1990
367 S-3578 Beta-lactam (cephalosporin) 2001 Phase 1
368 CS 834 (Prodrug of R-95867) Beta-lactam (cephalosporin) 2001 Phase 2
369 Tacapenem Beta-lactam (cephalosporin) 1996 Phase 2
372 Plusbacin A3 Cyclic-lipodepsipeptide 1999 Preclinical
373 A40926 (MDL 63042) Glycopeptide 1987 Preclinical
374 AC98-6446 Glycopeptide 2002 Preclinical
375 LT-00029 Glycopeptide 2009 Preclinical
377 SKF 104662 Glycopeptide 1988 Phase 1
378 Eremomycin Glycopeptide 1988 Phase 2
379 U-78608 Beta-lactam (monocarbam) 1988 Preclinical
380 BO-1165 Beta-lactam (monocarbam) 1986 Preclinical
381 RU44790 Beta-lactam (monocarbam) 1986 Preclinical
383 SQ-31299 Beta-lactam (monocarbam) 1987
384 SQ 32633 Beta-lactam (monocarbam) 1990
385 SQ 33110 Beta-lactam (monocarbam) 1990
387 CGP-31608 Beta-lactam (penem) 1986 Preclinical
388 HRE 664 Beta-lactam (penem) 1986 Preclinical
389 Tirandalydigin Beta-lactam (penem) 1987 Preclinical
390 Razupenem Beta-lactam (penem) 2004 Phase 2
391 Sulopenem Beta-lactam (penem) 1980 Phase 3
392 Ritipenem Beta-lactam (penem) 1986 Phase 3
394 FCE 25199 Beta-lactam (penem) 1989 Preclinical?
395 BRL 44154 Beta-lactam (penicillin) 1989 Phase 1
396 HKI 9924109 Beta-lactam (siderophore acylaminopenicillin) 2001 Preclinical
397 HKI 9924154 Beta-lactam (siderophore acylaminopenicillin) 2001 Preclinical
398 HKI 9924155 (amoxicillin adduct with synthetic catecholate) Beta-lactam (siderophore acylaminopenicillin) 2001 Preclinical
399 NZ2114 Antimicrobial peptide (plectasin derived) 2007 Preclinical
400 Mideplanin Glycopeptide (teicoplanin derivative) 1988 Preclinical
401 Mersacidin Antimicrobial peptide (lantibiotic) 1989
402 Mureidomycin A MraY inhibitor 1991
403 Mureidomycin B MraY inhibitor 1991
404 Mureidomycin C MraY inhibitor 1991
405 Mureidomycin D MraY inhibitor 1991
406 Pyrazolidinedione series - Wyeth MurB inhibitor 2003
407 SC 44914 Cell-wall synthesis inhibitor (quinoxaline) 1991 Preclinical
408 SC-44942-A Cell-wall synthesis inhibitor (quinoxaline) 1991 Preclinical
409 LY228238 Beta-lactam (cephalosporin, carbacephem [loracarbef derivative]) 1988 Preclinical
410 LY257128 Beta-lactam (cephalosporin, carbacephem [loracarbef derivative]) 1988 Preclinical
411 BMY 28232 (BMY 28271 is the prodrug) Beta-lactam (cephalosporin) 1988 Phase 1
412 Ro 23-9424 (fleroxacin + desacetylcefotaxime) Drug combination: beta-lactam (cephalosporin) + fluoroquinolone 1988 Phase 2
413 LB 10827 Beta-lactam (cephalosporin) 1999 Preclinical
414 E1010 (ER-35786) Beta-lactam (carbapenem) 1995 Phase 1
415 Ro 244383 Beta-lactam (cephalosporin) 1990 Preclinical
416 Ro 246392 Beta-lactam (cephalosporin) 1990 Preclinical
417 Ro 246778 Beta-lactam (cephalosporin) 1990 Preclinical
418 CB-182,548 Lipopeptide Preclinical
419 CB-182,549 Lipopeptide Preclinical
420 CB-182,561 Lipopeptide 2008 Preclinical
421 A54145 complex Lipopeptide 1988 Preclinical
422 ECO-0501 Envelope-active compound (glycosylated polyketide) 2004 Preclinical
423 AM 1732 Beta-lactam (cephalosporin) 1996 Preclinical
424 AM 1817 Beta-lactam (cephalosporin) 1996 Preclinical
425 FK041 Beta-lactam (cephalosporin) 1996 Preclinical
426 KA-094 Beta-lactam (cephalosporin) 1993 Preclinical
427 KST-150257 Beta-lactam (cephalosporin) 1997 Preclinical
428 KST-150290 Beta-lactam (cephalosporin) 1997 Preclinical
429 LB10522 Beta-lactam (cephalosporin) 1995 Preclinical
430 MC-02,306 Beta-lactam (cephalosporin) 1995 Preclinical
431 MC-02,331 Beta-lactam (cephalosporin) 1996 Preclinical
432 ME1209 Beta-lactam (cephalosporin) 1995 Preclinical
433 Ro 25-2016 Beta-lactam (cephalosporin) 1994 Preclinical
434 Ro 25-4835 Beta-lactam (cephalosporin) 1994 Preclinical
435 Ro 25-6833 Beta-lactam (cephalosporin) 1995 Preclinical
436 Ro 25-7103 Beta-lactam (cephalosporin) 1995 Preclinical
437 Ro 48-8391 Beta-lactam (cephalosporin) 1996 Preclinical
438 RU 59863 Beta-lactam (cephalosporin) 1994 Preclinical
439 TOC-39 Beta-lactam (cephalosporin) 1993 Preclinical
440 TOC-50 Beta-lactam (cephalosporin) 1993 Preclinical
441 YM-40220 Beta-lactam (cephalosporin) 1994 Preclinical
442 MC-02479 Beta-lactam (cephalosporin) 1997 Phase 1
443 Ro 40-6890 Beta-lactam (cephalosporin) 1992 Phase 1
444 Ceftrazonal bopentil (Ro 413399) (Prodrug of Ro 406890) Beta-lactam (cephalosporin) 1992 Phase 1
445 SC-002 Beta-lactam (cephalosporin) 1992 Phase 1
446 E1101 Beta-lactam (cephalosporin) 1994 Phase 2
447 LK10517 Beta-lactam (cephalosporin) 1994 Phase 2
448 Cefmatilen Beta-lactam (cephalosporin) 1992 Phase 3
449 Dual Action Cephalosporin (DAC) PD15768 Cephalosporin-quinolone 1995 Preclinical
450 Dual Action Cephalosporin (DAC) PD152912 Cephalosporin-quinolone 1995 Preclinical
451 Dual Action Cephalosporin (DAC) PD 152915 Cephalosporin-quinolone 1995 Preclinical
452 Ro 25-0534 Cephalosporin-quinolone 1993 Preclinical
453 NB2030 Cephalosporin-triclosan 2003 Preclinical
454 NB3352 (NB2030 analogue) Cephalosporin-triclosan 2003 Preclinical
455 NB3353 (NB2030 analogue) Cephalosporin-triclosan 2003 Preclinical
456 LY173013 Beta-lactam (cephalosporin) 1986 Preclinical
457 LY186826 (derived from LY173013) Beta-lactam (cephalosporin) 1986 Preclinical
458 CP-0467 Beta-lactam (cephem) 1992 Preclinical
459 OPC-20000 Beta-lactam (cephem) 1993 Preclinical
460 Coumamidine Gamma 1 Coumamidine 1988
461 BAL30544 Dihydrofolate reductase inhibitor (phthalazines) 2007 Preclinical
462 BAL30545 Dihydrofolate reductase inhibitor (phthalazines) 2007 Preclinical
463 AR-709 Dihydrofolate reductase inhibitor (diaminopyrimdine derivative) 2006 Phase 1
464 Pafuramidine (Prodrug of DB-75), DB-289 Dicationic molecule (pentamidine related) 2001 Phase 3
465 Diepoxin 1 Diepoxin 1993 Preclinical
466 Diepoxin 2 Diepoxin 1993 Preclinical
467 Diepoxin 3 Diepoxin 1993 Preclinical
468 Diepoxin 4 Diepoxin 1993 Preclinical
469 NB3322 Dihydrofolate reductase inhibitor 2003 Preclinical
470 Ro-474352 Dihydrofolate reductase inhibitor 1999 Preclinical
471 Ro-483706 Dihydrofolate reductase inhibitor 1999 Preclinical
472 Ro-619175 Dihydrofolate reductase inhibitor 1999 Preclinical
473 Ro-622753 Dihydrofolate reductase inhibitor 1999 Preclinical
474 Ro-626091 Dihydrofolate reductase inhibitor 1999 Preclinical
475 Ro-642550 Dihydrofolate reductase inhibitor 1999 Preclinical
476 KRQ-10018 Bacterial topoisomerase inhibitor 1997 Preclinical
477 RU 79115 Bacterial topoisomerase inhibitor (coumarin derivative) 1999 Preclinical
478 WCK-919 Fluoroquinolone 2001 Preclinical
479 BMY 41802 Bacterial topoisomerase inhibitor (napthyridone) 1990
480 BMY 41889 Bacterial topoisomerase inhibitor (napthyridone) 1990
481 WCK-771A Fluoroquinolone 2001 Phase 2
482 DC-159a Fluoroquinolone 2006 Phase 1
483 PGE-9509924 Quinolone 2000 Preclinical
484 CL 225014 DNA synthesis inhibitor (nitroimidazole) 1994 Preclinical
485 HB-EMAU DNA polymerase III inhibitor (6-anilinouracils (dGTP analogue)) 1999 Preclinical
486 HB-IMAU DNA polymerase III inhibitor (6-anilinouracils (dGTP analogue)) 1999 Preclinical
487 MB-EMAU DNA polymerase III inhibitor (6-anilinouracils (dGTP analogue)) 1999 Preclinical
488 MB-IMAU DNA polymerase III inhibitor (6-anilinouracils (dGTP analogue)) 1999 Preclinical
489 ME2303 DNA synthesis inhibitor (anthracycline) 1991 Phase 2
490 A-867191 Fluoroquinolone 1994 Phase 2
491 REP 6021 DNA synthesis inhibitor (pyrimidinone (thioxo-thiazolidin-4-one series)) 2004 Preclinical
492 DRG-16 DNA synthesis inhibitor (pyrrolobenzodiazepine) 2004 Preclinical
493 ELB-21 DNA synthesis inhibitor (pyrrolobenzodiazepine) 2004 Preclinical
494 SJG-136 DNA synthesis inhibitor (pyrrolobenzodiazepine) 2004 Phase 2
495 MF-961 Fluoroquinolone (rufloxacin derivative) 1989 Preclinical
496 Bioxalomycin alpha 2 DNA synthesis inhibitor 1993 Preclinical
497 RP-67829 Bacterial topoisomerase inhibitor (benzonaphthyridine) 1991 Preclinical
498 DX-619 Fluoroquinolone 2003 Phase 1
499 QX-2987 Bacterial topoisomerase inhibitor 2004 Preclinical
500 QX-3073 Bacterial topoisomerase inhibitor 2004 Preclinical
501 PD 0199646 Bacterial topoisomerase inhibitor (2-hydroxyisoquinolone) 2000
502 WQ-3345 Fluoroquinolone 2000 Preclinical
503 WQ-2944 (7-methylamino) Fluoroquinolone 2000 Preclinical
504 WQ-3188 (7-(2-hydroxyethylamino)) Fluoroquinolone 2000 Preclinical
505 WQ-3198 (7-(3-hydroxypropylamino)) Fluoroquinolone 2000 Preclinical
506 E-3846 Fluoroquinolone 1989 Preclinical
507 WQ-2756 Fluoroquinolone 1996 Preclinical
508 WQ-2765 Fluoroquinolone 1996 Preclinical
510 WQ 3330 Fluoroquinolone 1999 Preclinical
511 BMY 40062 Fluoroquinolone 1988 Preclinical
512 WQ-3335 Fluoroquinolone 2005 Preclinical
513 KB-5246 Fluoroquinolone (tetracyclic quinolone) 1988 Phase 1 (2)
514 Oxaquin (prodrug of MCB3681) Fluoroquinolone-oxazolidinone hybrid 2005 Phase 1
515 Clinafloxacin Fluoroquinolone 1986 Phase 3
516 ABI-0094 Rifamycin 2005 Preclinical
517 ABI-0299 Rifamycin 2005 Preclinical
518 CHP-105 DnaK inhibitor 2008 Preclinical
519 Fosmidomycin (FR 31564) DXP reductoisomerase inhibitor (phosphonic acid derivative) Phase 2
521 MC-04124 Efflux pump inhibitor 2000 Preclinical
522 MC207110 Efflux pump inhibitor 2000 Preclinical
523 MC-278,537 Efflux pump inhibitor 2001 Preclinical
524 MC-04112 Efflux pump inhibitor 2001 Preclinical
526 MC 02595 Efflux pump inhibitor 2000 Preclinical
527 UK-57-562 Efflux pump inhibitor 1999 Preclinical
528 MC-210375 Efflux pump inhibitor 2001 Preclinical
529 MC 510050 (MF-EA-371 δ) Efflux pump inhibitor (O-sulfates of benastatins A and B) 2000 Preclinical
530 MC 510051 (MF-EA-371 α) Efflux pump inhibitor (O-sulfates of benastatins A and B) 2000 Preclinical
531 GE 21640A Protein synthesis inhibitor (elfamycin) 1993 Preclinical
532 RU 75411 MraY inhibitor (nucleoside) 2002 Preclinical
533 MUT37307 Fatty acid synthesis inhibitor (FabI inhibitor) 2008 Preclinical
534 CG-400462 Fatty acid synthesis inhibitor (FabI inhibitor, naphthylidine derivative) 2004 Preclinical
535 CG-400463 Fatty acid synthesis inhibitor (FabI inhibitor, naphthylidine derivative) 2006 Preclinical
536 JNJ-17156581 Macrolide (14-membered macrolide, fluoroketolide) 2003 Preclinical
537 JNJ-17156815 Macrolide (14-membered macrolide, fluoroketolide) 2003 Preclinical
539 A-80556 (A-65326.HCL) Fluoroquinolone 1992 Preclinical
543 DC 756 Fluoroquinolone 1998 Preclinical
544 DQ-113 Fluoroquinolone 2000 Preclinical
545 E-4721 Fluoroquinolone 1992 Preclinical
546 CI-990 Fluoroquinolone 1990 Preclinical
548 PD 138312 Fluoroquinolone 1993 Preclinical
549 PD 140248 Fluoroquinolone 1993 Preclinical
550 Premafloxacin (U95376) Fluoroquinolone 1995 Preclinical
551 PD 135661 Fluoroquinolone 1996 Preclinical
552 PD 161144 Fluoroquinolone 1996 Preclinical
553 PD-161148 Fluoroquinolone 1996 Preclinical
554 PD 161314 Fluoroquinolone 1996 Preclinical
555 PD 161315 Fluoroquinolone 1996 Preclinical
556 PD 163048 Fluoroquinolone 1996 Preclinical
557 PD 163049 Fluoroquinolone 1996 Preclinical
558 PD 163753 Fluoroquinolone 1996 Preclinical
559 S-32730 Fluoroquinolone 1995 Preclinical
560 S-34109 Fluoroquinolone 1998 Preclinical
561 Y-688 Fluoroquinolone 1995 Preclinical
562 Cetefloxacin Fluoroquinolone 1992 Phase 1
563 DK-507k Fluoroquinolone 2001 Phase 1
564 DW-286a Fluoroquinolone 2001 Phase 1
565 Olamufloxacin (HSR-903) Fluoroquinolone 1998 Phase 3
566 A245475 Fluoroquinolone 1999
567 ABI200 Engineered bacteriophage endolysin 2009 Preclinical
568 Balhimycin Glycopeptide 1993 Preclinical
570 UK 68,597 Glycopeptide 1989
571 Chloroorienticin B (S-3662) Glycopeptide 1991
572 LT-00786 Glycopeptide 2010 Preclinical
573 Glycothiohexide Glycothiopeptide 1993 Preclinical
574 PGE 4175997 Quinolone 1999 Preclinical
575 PGE 9262932 Quinolone 1999 Preclinical
576 A-170568 Fluoroquinolone 1998 Preclinical
577 A-238086 Bacterial topoisomerase inhibitor (pyridone derivative) 1999
578 A270117 Bacterial topoisomerase inhibitor (pyridone derivative) 1999
579 Walkmycin A Histidine kinase inhibitor 2010 Preclinical
580 Walkmycin B Histidine kinase inhibitor 2010 Preclinical
581 Walkmycin C Histidine kinase inhibitor 2010 Preclinical
582 Walkmycin D Histidine kinase inhibitor 2010 Preclinical
583 Walkmycin E Histidine kinase inhibitor 2010 Preclinical
584 Walkmycin F Histidine kinase inhibitor 2010 Preclinical
585 PGE 1818689 Quinoyl-carbacephem 1998 Preclinical
586 CE-129941 Hygromycin A 2006 Preclinical
587 CRL-1018 Immunomodulator 1995 Preclinical
588 CRL 1072 Immunomodulator (poloaxmer) 1995 Preclinical
590 RWJ-49815 Antivirulence agent (two-component system inhibitor) 1997 Preclinical
591 RWJ-60563 Antivirulence agent (two-component system inhibitor) 1997 Preclinical
592 CP 654743 Macrolide (16-membered macrolide, ketolide) 2000 Preclinical
595 CHIR 380 Macrolide (16-membered macrolide, ketolide) 2003 Preclinical
596 CHIR 988 Macrolide (16-membered macrolide, ketolide) 2003 Preclinical
597 JNJ-17155437 Macrolide (15-membered macrolide, ketolide) 2002 Preclinical
598 JNJ-17155528 Macrolide (15-membered macrolide, ketolide) 2002 Preclinical
599 API7444 Antimicrobial peptide (lantibiotic) 2004
600 MF-BA1768-a Antimicrobial peptide (lantibiotic) 2001
601 MF-BA1768-b Antimicrobial peptide (lantibiotic) 2001
602 Plectasin Antimicrobial peptide (fungal defensin, lipid II binder) 2006 Preclinical
603 Caprazamycin A MraY inhibitor (liponucleoside) 2002 Preclinical
604 Caprazamycin B MraY inhibitor (liponucleoside) 2002 Preclinical
605 Caprazamycin C MraY inhibitor (liponucleoside) 2002 Preclinical
606 Caprazamycin D MraY inhibitor (liponucleoside) 2002 Preclinical
607 Caprazamycin E MraY inhibitor (liponucleoside) 2002 Preclinical
608 Caprazamycin F MraY inhibitor (liponucleoside) 2002 Preclinical
609 HMR 1043 Lipopeptide 2000 Preclinical
610 Laspartomycin and analogues Lipopeptide 2001
611 CHIR-090 Lipopolysaccharide synthesis inhibitor (LpxC inhibitor) 2010 Preclinical
612 Socorromycin Macrolactam 1993 Preclinical
613 CP-544372 Macrolide 1998 Preclinical
614 GW 708408 Macrolide 2004 Preclinical
615 GW 773546 Macrolide 2004 Preclinical
616 Macquarimicin A Macrolide 1986 Preclinical
617 YM17K (MC 352) Macrolide 1993 Preclinical
618 EP-014598 Macrolide (6,11-bicyclolide scaffold) 2007
619 EP-014413 Macrolide (bridged bicyclic) 2007
620 EP-014887 Macrolide (oxime 3,6-bicyclolide) 2007
621 P91022 Methylcarbapenem 2006
622 CP-919471 Hygromycin A 2006 Preclinical
623 CP-929898 Hygromycin A 2006 Preclinical
624 CE-156811 Hygromycin A 2006 Preclinical
626 PTX2416 Beta-lactam (monobactam) 2003 Preclinical
627 SQ 83,831 Beta-lactam (monobactam) 1988
628 Pirazmonam Beta-lactam (monocarbam, siderophore monobactam) 1985 Preclinical
630 Munumbicin A Antimicrobial peptide 2003 Preclinical
631 Munumbicin B Antimicrobial peptide 2003 Preclinical
632 Munumbicin C Antimicrobial peptide 2003 Preclinical
633 Munumbicin D Antimicrobial peptide 2003 Preclinical
634 DQ-1 MurF inhibitor (diarylquinoline) 2007 Preclinical
635 DQ-2 MurF inhibitor (diarylquinoline) Phase 1
636 Sch 38519 Naphthaquinone 1986 Preclinical
637 Napsamycin A Peptidylnucleoside 1992 Preclinical
638 Napsamycin B Peptidylnucleoside 1992 Preclinical
639 Napsamycin C Peptidylnucleoside 1992 Preclinical
640 Napsamycin D Peptidylnucleoside 1992 Preclinical
641 PA-1297 Protein synthesis inhibitor 1997 Preclinical
642 PA-1343 Protein synthesis inhibitor 1997 Preclinical
643 Pretomanid Nitroimidazole 1997 Phase 3
644 Rodaplutin Nucleoside 1986 Preclinical
645 AM-7359 Oxazolidinone 2006 Preclinical
646 AM-7383 Oxazolidinone 2006 Preclinical
647 LCB01-0062 Oxazolidinone 2007 Preclinical
648 PF-00708093 Oxazolidinone 2009 Preclinical
649 PF-02341752 Oxazolidinone 2009 Preclinical
650 Sutezolid Oxazolidinone 2009 Phase 2 (NCT05971602)
651 PNU-101603 Oxazolidinone 2009 Preclinical
652 PNU-107922 Oxazolidinone 1998 Preclinical
653 PNU-140457 Oxazolidinone 1998 Preclinical
657 MCB3130 Oxazolidinone-quinolone 2003 Preclinical
658 MCB3382 Oxazolidinone-quinolone 2003 Preclinical
659 MCB116 Oxazolidinone 2002 Preclinical
660 MCB1033 Oxazolidinone 2002 Preclinical
661 OX-22-043 Oxazolidinone 2002 Preclinical
662 OX-22-045 Oxazolidinone 2002 Preclinical
663 Benzoxazinone Oxazolidinone 1999
664 Benzthiazinone Oxazolidinone 1999
665 Pyrazinoindole Oxazolidinone 1999
666 Oxazinoindole Oxazolidinone 1999
667 Saigenmycin Oxazolomycin 1986 Preclinical
668 Actinonin (VRC483) Peptide deformylase inhibitor 1999 Preclinical
669 BB-3497 Peptide deformylase inhibitor 2000 Preclinical
672 NVD PDF 713 Peptide deformylase inhibitor 2000 Phase 1
673 VIC-104959 Peptide deformylase inhibitor 2000 Phase 1
674 VRC3852 Peptide deformylase inhibitor 2000 Phase 1
675 VRC-3324 Peptide deformylase inhibitor 2000 Phase 1
676 VRC3375 Peptide deformylase inhibitor 2000 Phase 1
677 VRC4307 Peptide deformylase inhibitor 2000 Phase 1
678 VRC4887 Peptide deformylase inhibitor 2000 Phase 1
680 FCE 24964 (Prodrug FCE 25199) Beta-lactam (penem) 1992 Preclinical
681 CP-65-207 Beta-lactam (penem) 1988 Phase 1
682 Calpinactam Antimicrobial peptide 2009 Preclinical
683 Cypemycin Antimicrobial peptide 1994 Preclinical
684 PMT-1185 Antimicrobial peptide 2007 Preclinical
685 PR-39 Antimicrobial peptide 1995 Preclinical
686 RTA-3 Antimicrobial peptide 2007 Preclinical
688 BPI 23 Antimicrobial peptide 1992 Phase 2
689 E 5531 Antimicrobial peptide 1992 Phase 2
690 XMP-629 Antimicrobial peptide 2001 Phase 2
691 Iseganan Antimicrobial peptide 1997 Phase 3
692 Dermaseptin Derivative- K4-S4(1-13) Antimicrobial peptide 2001
693 Dermaseptin Derivative- K4-S4(1-16) Antimicrobial peptide 2001
694 PAD-1.17 Antimicrobial peptide 2007
695 Eurocin Antimicrobial peptide (defensin) 2007
696 GE37468A Antimicrobial peptide (thiazolyl peptide antibiotic) 1994 Preclinical
697 BB-83698, GBB 83698, GSQ 83698 Peptide deformylase inhibitor 2001 Preclinical
698 BB 83815 Peptide deformylase inhibitor 2002 Preclinical
699 BB 83857 Peptide deformylase inhibitor 2002 Preclinical
700 BB 84234 Peptide deformylase inhibitor 2002 Preclinical
701 BB 84416 Peptide deformylase inhibitor 2002 Preclinical
702 BB 84518 Peptide deformylase inhibitor 2002 Preclinical
703 BB 84887 Peptide deformylase inhibitor 2002 Preclinical
704 BB 84888 Peptide deformylase inhibitor 2002 Preclinical
705 BB 85035 Peptide deformylase inhibitor 2002 Preclinical
706 BL2060 Antimicrobial peptide (peptidomimetic oligomer) 2008 Preclinical
707 Oleuropein Phenolic sarcolid antioxidant 2005
708 Neopyrrolomycin Phenylpyrrole 1994 Preclinical
709 BAL0030543 Dihydrofolate reductase inhibitor 2007 Preclinical
710 A82810 Polyether 1989
711 CP-73064 Polyether 1989
712 GL 047374 Polyheterocyclic amide 2001 Preclinical
713 GL 118172 Polyheterocyclic amide 2001 Preclinical
714 GL 243287 Polyheterocyclic amide 2001 Preclinical
715 GL 359986 Polyheterocyclic amide 2001 Preclinical
716 GL 478057 Polyheterocyclic amide 2001 Preclinical
717 GL 48087 Polyheterocyclic amide 2001 Preclinical
718 GL 521997 Polyheterocyclic amide 2001 Preclinical
719 GL 548043 Polyheterocyclic amide 2001 Preclinical
720 GL 568816 Polyheterocyclic amide 2001 Preclinical
721 GL 579225 Polyheterocyclic amide 2001 Preclinical
722 GL 663142 Polyheterocyclic amide 2001 Preclinical
723 GL 700241 Polyheterocyclic amide 2001 Preclinical
724 GL 701649 Polyheterocyclic amide 2001 Preclinical
725 GL 703027 Polyheterocyclic amide 2001 Preclinical
726 GL 832293 Polyheterocyclic amide 2001 Preclinical
727 GL 886217 Polyheterocyclic amide 2001 Preclinical
728 GL 898298 Polyheterocyclic amide 2001 Preclinical
729 Tolevamer Polymer 2000 Phase 3
730 CB-182804, CB-182,804 Polymyxin 2010 Phase 1
731 Trospectomycin (U 63366 F) Aminoglycoside 1984 Phase 3
732 Decaplanin (M 861410) Glycopeptide 1991 Preclinical
733 PNU-179004 Oxazolidinone 1999 Preclinical
734 PNU-171832 Oxazolidinone 1999 Preclinical
735 PNU-173954 Oxazolidinone 1999 Preclinical
736 PNU-176665 Oxazolidinone 1999 Preclinical
737 PNU-179954 Oxazolidinone 1999 Preclinical
738 PNU-288034 Oxazolidinone 2002 Phase 1
739 S-6123 Oxazolidinone 1987 Preclinical
740 DuP 105 Oxazolidinone 1987 Phase 1
741 DuP 721 Oxazolidinone 1987 Phase 1
742 FMA 0122 Macrolide (14-membered macrolide) 1999 Preclinical
743 FMA 0713 Macrolide (14-membered macrolide) 1999 Preclinical
744 FMA 122 Macrolide (14-membered macrolide) 1999 Preclinical
745 FMA-1485 Macrolide (14-membered macrolide, ketolide) 1999 Preclinical
746 FMA199 Macrolide (14-membered macrolide) 1999 Preclinical
747 FMA481 Macrolide (14-membered macrolide) 1999 Preclinical
748 TEA 0929 Macrolide (14-membered macrolide) 1999 Preclinical
749 EP 12344 Macrolide (ketolide) 2003 Preclinical
750 A-217213 Macrolide (ketolide) 2001 Preclinical
751 CP 642959 Macrolide (ketolide) 2001 Preclinical
752 GI-448 Macrolide (ketolide) 2001 Preclinical
753 HMR 3004 Macrolide (ketolide) 1996 Phase 2
754 HMR 3787 (RU64399) Macrolide (ketolide) 1999 Preclinical
755 CGP7040 Rifamycin 1987 Preclinical
756 HMR 3562 Macrolide (ketolide) 1999 Preclinical
757 Eperezolid Oxazolidinone 1995 Phase 3
758 PNU-173995 Oxazolidinone 2001 Preclinical
759 A-40,926 (MDL 63042) Glycopeptide 2002 Preclinical
760 Vertilmicin Aminoglycoside 2010 Preclinical
761 MDL 62879 Protein synthesis inhibitor 1993 Preclinical
762 PD 155392 Protein synthesis inhibitor (boxazomycin derivative) 1995 Preclinical
763 PD 149060 Protein synthesis inhibitor (boxazomycin derivative) 1995 Preclinical
764 Boxazomycin B Protein synthesis inhibitor (boxazomycin derivative) 1995 Preclinical
765 AM-3005 Mutilin-quinolone hybrid 2008 Preclinical
766 Antibiotic 89-07 Aminoglycoside 1995 Preclinical
768 EP 1304 Macrolide (ketolide) 2003 Preclinical
769 VRC 4219 Protein synthesis inhibitor 2001 Preclinical
770 EP 13159 Macrolide (ketolide) 2003 Preclinical
771 EP-13417 Macrolide (ketolide) 2003 Preclinical
772 EP-13420 Macrolide (ketolide) 2003 Preclinical
773 TP-271 Tetracycline 2010 Preclinical
774 WAY 152288 Tetracycline 1998 Preclinical
775 GINA-220 Protein synthesis inhibitor 2005 Preclinical
776 GINA-301 Protein synthesis inhibitor 2005 Preclinical
777 CL-329998 (DMG-MINO) Glycylcycline 1993 Preclinical
778 CL-331002 (DMG-DMDOT) Glycylcycline 1993 Preclinical
779 CHIR 281 Macrolide (ketolide) 2003 Preclinical
780 CHIR 787 Macrolide (ketolide) 2003 Preclinical
781 EP 13543 Macrolide (ketolide) 2003 Preclinical
782 EP 1562 Macrolide (ketolide) 2003 Preclinical
783 Difficidin Protein synthesis inhibitor 1986 Preclinical
784 Oxydifficidin Protein synthesis inhibitor 1986 Preclinical
785 Sorangicin A RNA Polymerase inhibitor 1986
786 A-63075 Macrolide 1987 Preclinical
787 LY281389 Macrolide 1989 Preclinical
788 SCH 37644 Macrolide 1987 Preclinical
789 TE-802 Macrolide 1995 Preclinical
790 YM133 (IMC-XV) Macrolide 1990 Preclinical
791 BAL19403 Macrolide 2006 Phase 1
792 YM 17K (MC 352) Macrolide 1991 Phase 2
793 A-72299 Macrolide 1990
794 A-74950 Macrolide 1990
795 A-75835 Macrolide 1990
797 acpP PMO Phosphorodiamidate morpholino oligomer (PMO) 2004 Preclinical
798 VIC-106632 Oxazolidinone 2005 Preclinical
799 VIC-106675 Oxazolidinone 2005 Preclinical
800 VIC-106701 Oxazolidinone 2005 Preclinical
801 VIC-106734 Oxazolidinone 2005 Preclinical
802 VIC-106822 Oxazolidinone 2005 Preclinical
803 VIC-106828 Oxazolidinone 2005 Preclinical
804 VIC-106841 Oxazolidinone 2005 Preclinical
805 VIC-106871 Oxazolidinone 2005 Preclinical
806 VIC-106922 Oxazolidinone 2005 Preclinical
807 DA-7686 Oxazolidinone 2000 Preclinical
808 Imidazole-Benzoxazinyl-Oxazolidonones Oxazolidinone 2000 Preclinical
809 OCHID 0619 Oxazolidinone 2011 Preclinical
810 Oxazolidinones with acetaminomethyl side chains Oxazolidinone 2000 Preclinical
811 PF-00422602 Oxazolidinone 2006 Preclinical
812 PF-987296 Oxazolidinone 2006 Preclinical
813 PNU-177553 Oxazolidinone 2001 Preclinical
814 PNU-182347 Oxazolidinone 2000 Preclinical
815 Ranbezolid (RBx 7644) Oxazolidinone 2004 Preclinical
816 RWJ 306490 Oxazolidinone 2000 Preclinical
818 Rx-01 series: Rx-01_413 Oxazolidinone 2005 Preclinical
819 Rx-01 series: Rx-01_445 Oxazolidinone 2005 Preclinical
820 Radezolid Oxazolidinone 2005 Preclinical
821 Rx-01_423 Oxazolidinone 2005 Preclinical
822 VRC-3055 Oxazolidinone 2000 Preclinical
823 VRC-3406 Oxazolidinone 2000 Preclinical
824 VRC-3599 Oxazolidinone 2000 Preclinical
825 VRC-3808 Oxazolidinone 2001 Preclinical
826 VRC-3816 Oxazolidinone 2000 Preclinical
827 VRC-3923 Oxazolidinone 2001 Preclinical
828 VRC-4003 Oxazolidinone 2001 Preclinical
829 VRC3054 Oxazolidinone 2000 Preclinical
830 VRC3889 Oxazolidinone 2000 Preclinical
833 RWJ-416457 Oxazolidinone 2002 Preclinical
834 OCID 0050 Oxazolidinone 2003 Preclinical
835 VRC 3807 Oxazolidinone 2003 Preclinical
836 VRC 3924 Oxazolidinone 2003 Preclinical
837 VRC-3125 Oxazolidinone 2002 Preclinical
838 VRC-3783 Oxazolidinone 2002 Preclinical
839 VRC-4228 Oxazolidinone 2002 Preclinical
840 Paldimycin (U-70138F) Paulomycin 1986
841 Thiocillin Antimicrobial peptide (protein synthesis inhibitor) 1990
842 VIC-105535 Oxazolidinone 2005 Preclinical
843 SB-264128 Pleuromutilin 2000 Preclinical
844 SB-247386 Pleuromutilin 1999 Preclinical
845 SB-268091 Pleuromutilin 1999
846 Rx100472 Aminoacyl-tRNA synthetase inhibitor (methionyl tRNA synthetase [MetRS] inhibitor , pyrimidine) 2008 Preclinical
847 RBX 8700 Oxazolidinone 2004 Preclinical
848 Efepristin Streptogramin 1995 Phase 2
849 VIC-104742 Oxazolidinone 2005 Preclinical
850 VIC-105277 Oxazolidinone 2005 Preclinical
851 Bederocin Aminoacyl-tRNA synthetase inhibitor (methionyl tRNA synthetase [MetRS] inhibitor) 2004 Phase 1
852 EP 1350 Macrolide (16-membered macrolide, tylosine derivative) 2003 Preclinical
853 MCB-3681 (prodrug of MCB3837) Oxazolidinone-quinolone 2006
854 ABX-96 Oxazolidinone 2001 Preclinical
855 Tan 1057 Protein synthesis inhibitor (dipeptide) 2001 Preclinical
856 BC-3205 Pleuromutilin 2009 Phase 1
857 Timcodar Efflux pump inhibitor (pyridine) 2009 Preclinical
858 Pyrroindomicin A and B Pyrroindomicin 1993 Preclinical
859 A-77143 Quinolone 1992 Preclinical
860 Cyclothialidine (Ro 09-1437) Quinolone 1992 Preclinical
861 DN3 27-1 Quinolone 1997 Preclinical
863 E-4767 Quinolone 1993 Preclinical
864 NM-394 Quinolone 1992 Preclinical
865 PD-117558 Fluoroquinolone 1986 Preclinical
867 Ro091168 Quinolone 1991 Preclinical
868 S-31076 Quinolone 1993 Preclinical
869 U-87947 Quinolone 1991 Preclinical
870 U-91939E Quinolone 1991 Preclinical
871 WQ 0835 Quinolone 1995 Preclinical
872 WQ 1197 Quinolone 1992 Preclinical
873 WQ 2128 Quinolone 1994 Preclinical
874 WQ1101 Quinolone 1991 Preclinical
875 WQ175 Quinolone 1992 Preclinical
876 Y-34867 Quinolone 1998 Preclinical
877 CS-940 Fluoroquinolone 1993 Phase 2
878 Y-25024 Quinolone 1988
879 SEP-132617 Quinoline-indole 1999 Preclinical
880 SEP-32196 Quinoline-indole 1999 Preclinical
881 SEP 118843 Quinoline-indole 2000 Preclinical
882 SEP 137199 Quinoline-indole 2000 Preclinical
883 SEP 147960 Quinoline-indole 2000 Preclinical
884 SEP 155342 Quinoline-indole 2000 Preclinical
885 SEP 155347 Quinoline-indole 2000 Preclinical
886 SEP 156117 Quinoline-indole 2000 Preclinical
887 SEP 156131 Quinoline-indole 2000 Preclinical
888 PGE 7119699 Quinolonyl-carbacephem 1997 Preclinical
890 CP111905-00 Hygromycin A 1992 Preclinical
891 Rifaquizinone Rifamycin-quinolone hybrid 2007 Phase 2 (NCT03964493)
892 ABI-0010N Rifamycin 2004 Preclinical
893 ABI-0047N Rifamycin 2004 Preclinical
894 ABI-0185N Rifamycin 2004 Preclinical
895 ABI-0197N Rifamycin 2004 Preclinical
896 GSQ 10547 RNA synthesis inhibitor (hetero ARomatic Polyamide [HARP]) 2001 Preclinical
897 GSQ 11203 RNA synthesis inhibitor (hetero ARomatic Polyamide [HARP]) 2001 Preclinical
898 GSQ 2287 RNA synthesis inhibitor (hetero ARomatic Polyamide [HARP]) 2001 Preclinical
899 GSQ 5028 RNA synthesis inhibitor (hetero ARomatic Polyamide [HARP]) 2001 Preclinical
900 GSQ 7302 RNA synthesis inhibitor (hetero ARomatic Polyamide [HARP]) 2001 Preclinical
901 s-Triazines compounds s-Triazine 2009 Preclinical
902 AM-114 Beta-lactamase inhibitor (oxapenem) 2002 Preclinical
903 RP 106,972 Streptogramin 1997 Preclinical
905 RP 74501/RP 74502 Streptogramin 1992 Phase 1
906 Reutericyclin Analogue: 867 Tetramic acid 2010 Preclinical
907 Reutericyclin Analogue: 1135 Tetramic acid 2010 Preclinical
908 Reutericyclin Analogue: 1137 Tetramic acid 2010 Preclinical
909 Reutericyclin Analogue: 1138 Tetramic acid 2010 Preclinical
910 Reutericyclin Analogue: 1139 Tetramic acid 2010 Preclinical
911 RM4809 Thiazolide Preclinical
912 RM4807 Thiazolide 2005
913 MDL 63246 Glycopeptide, thiazolopeptide 1993 Preclinical
914 Nocathiacin I Thiazolyl peptide 2003 Preclinical
915 BMS-411886 (Water Soluble analogue of BMS-249524) Thiazolyl peptide 2003 Preclinical
916 BMS-461996 (Water Soluble analogue of BMS-249524) Thiazolyl peptide 2003 Preclinical
917 A10255 Thiopeptide 1989
918 NXL101 Quinolone 2005 Phase 1
919 CNH365.396 Tricyclic dione ester 2012 Preclinical
920 Tripropeptin A Tripropeptin lipodepsipeptide 2005
921 Tripropeptin B Tripropeptin lipodepsipeptide 2005
923 Tripropeptin D Tripropeptin lipodepsipeptide 2005
924 Tripropeptin E Tripropeptin lipodepsipeptide 2005
925 Tripropeptin Z Tripropeptin lipodepsipeptide 2005
926 CB 102930 Aminoacyl-tRNA synthetase inhibitor (phenylanalyl-tRNA synthetase [PheRS] inhibitor) 2001 Preclinical
927 AM-1939 Fluoroquinolone 2003 Preclinical
928 CP-74667 Fluoroquinolone 1991 Preclinical
929 WIN 57273 Fluoroquinolone 1989 Preclinical
930 WQ-2724 Fluoroquinolone 1997 Preclinical
931 WQ-2743 Fluoroquinolone 1997 Preclinical
932 Ecenofloxacin (CFC-222) Fluoroquinolone 1995 Phase 1
933 Amifloxacin Fluoroquinolone Phase 2
934 Bay Y3118 Fluoroquinolone 1992 Phase 2
935 BMY 43748 Fluoroquinolone 1991 Preclinical
936 Grepafloxacin Fluoroquinolone 1991 Approved by FDA in 1997
937 Difloxacin Fluoroquinolone Phase 2
938 AM-1174 Fluoroquinolone 1990 Preclinical
939 Y-26611 Fluoroquinolone 1990 Phase 2
940 Gatifloxacin Fluoroquinolone 1992 Approved by FDA in 2010
944 CP-67,015 Quinolone 1987 Preclinical
946 PD 124816 Quinolone 1988 Preclinical
948 Citreamicin α Xanthone 1988 Preclinical
949 Citreamicin β Xanthone 1988 Preclinical
950 Vermisporin Xanthone 1990 Preclinical
951 D2A22 Synthetic peptide 2003
952 Sanfetrinem Beta-lactam (tribactam) 1992 Phase 2 (NCT05388448)
953 SRI-011225 Beta-lactam 2012 Preclinical
954 T-5575 Beta-lactam (carboxypenam) 1992 Preclinical
955 T-5578 Beta-lactam (carboxypenam) 1992 Preclinical
956 GD-40 Beta-lactamase inhibitor 1996 Preclinical
957 MC-207252 Antibiotic adjuvant 1995 Preclinical
958 Ro 48-1256 Beta-lactamase inhibitor (monobactam) 1995 Preclinical
959 Ro 481220 Beta-lactamase inhibitor (penicillanic acid sulfone) 1994 Preclinical
960 Syn-2190 Beta-lactamase inhibitor (monobactam) 1997 Preclinical
961 BRL-42715 Beta-lactamase inhibitor (penem) 1987 Phase 1
962 CP-72,193 Beta-lactamase inhibitor 1988
963 RWJ 157479 Beta-lactamase inhibitor 1999
964 LEK-157 Beta-lactamase inhibitor (carbapenem) 2007 Preclinical
965 BLI-489 Beta-lactamase inhibitor (carbapenem) 2007 Phase 1
967 J110441 Beta-lactamase inhibitor (methylcarbapenem) 1999 Preclinical
968 2-aminoquinolone 2008 Preclinical
969 A63483 1989 Preclinical
970 Aryl Rhodanine 2008 Preclinical
971 ATWL25 2008 Preclinical
972 CB-182575 2008 Preclinical
973 CX1 (para-guanidinoethylcalix[4]arene) 2008 Preclinical
974 Dihydroxybenzofuran 2008 Preclinical
975 EXEG1706 2003 Preclinical
976 MBX-1066 Small molecule 2009
977 VRC 5264 2002 Preclinical
978 Squalamine 1996 Phase 2
979 Aldeomycin 1989
980 Chloraziomycin 1989
981 Leinamycin, DC107 1990
982 MC21A 2001
983 Poststatin 1990
984 SB22484 1989
985 Ferrimycin A Sideromycin 1960 Preclinical
986 N-methyl/ethyl-lincomycin stereochemical derivatives Lincosamide 1965 Preclinical
987 Ziracin Aminoglycoside 1965 Phase 3
988 Phleomycin Glycopeptide Preclinical
989 Actinocyl-gramicidin S Gramicidin 1966 Preclinical
990 Hedamycin Pluramycin 1966
991 Coumermycin A1 Aminocoumarin 1966
992 Cirolemycin 1967 Preclinical
993 1,2,5-Selenadiazole derivatives, Inc: NSC 93169 1966 Preclinical
994 1,2,5-Selenadiazole derivatives, Inc: NSC 84963 1966 Preclinical
995 LL-RA6950-BA 1965 Preclinical
996 LL-RA6950-BB 1965 Preclinical
997 LL-AE705-Y Quinone 1965 Preclinical
998 Rancomycin 1 (U-22583) Lincosamide 1967 Preclinical
999 Rancomycin 2 (U-25873) Lincosamide 1967 Preclinical
1000 Biphenomycin A (LL-AF283α) Biphenomycin 1967 Preclinical
1001 Halomicin complex Ansamycin 1967 Preclinical
1002 LL-AB 664 Steptothricin 1967 Preclinical
1003 N-methoxy-benzylpenicillinamide Beta-lactam (penicillin) 1967 Preclinical
1004 N-ethoxy-benzylpenicillinamide Beta-lactam (penicillin) 1967 Preclinical
1005 N-propoxy-benzylpenicillinamide Beta-lactam (penicillin) 1967 Preclinical
1006 N-methoxy-phenoxymethylpenicillinamide Beta-lactam (penicillin) 1967 Preclinical
1007 N-methoxy-(2,6-dimethoxyphenyl)penicillinamide Beta-lactam (penicillin) 1967 Preclinical
1008 N-benzyloxy-benzylpenicillinamide Beta-lactam (penicillin) 1967 Preclinical
1009 Furazolium Chloride/ NF-963 Nitrofuran 1967 Preclinical
1010 2-Nitroimidazole derivatives Nitroimidazole 1967 Preclinical
1011 LL-Z1220 Natural product antibiotic 1969 Preclinical
1012 Aliphatic acylamido derivatives of Coumermycin A1 Aminocoumarin 1969 Preclinical
1013 SQ 18506 Nitrofuran 1969 Preclinical
1014 Mannosidostreptomycin (Streptomycin analogue) Aminoglycoside 1969 Preclinical
1015 Meonomycin complex A Moenomycin 1965 Preclinical
1016 Meonomycin complex B Moenomycin 1965 Preclinical
1017 Meonomycin complex C Moenomycin 1965 Preclinical
1018 Meonomycin complex D Moenomycin 1965 Preclinical
1019 C-73X Natural small molecule 1966 Preclinical
1020 CIBA 36278A-Ba Beta-lactam (cephalosporin) 1970 Preclinical
1022 6-methoxy-1-phenazinol 5,10-dioxide cupric complex 1970 Preclinical
1023 Nifuratrone (N-(2-hydroxyethyl)-a-(5.nitro-2-furyl) nitrone) 1970 Preclinical
1024 BL-P 1654 Beta-lactam (penicillin) 1970 Preclinical
1026 Acetoxymethyl ester of Ampicillin Beta-lactam (penicillin) 1970 Preclinical
1027 Propionyloxymethyl ester of Ampicillin Beta-lactam (penicillin) 1970 Preclinical
1028 n-Butyryloxymethyl ester of Ampicillin Beta-lactam (penicillin) 1970 Preclinical
1029 Isobutyryloxymethyl ester of Ampicillin Beta-lactam (penicillin) 1970 Preclinical
1030 Pivampicillin Beta-lactam (penicillin) 1970 Preclinical
1031 Alpha-Ethyl-n-butyryloxymethyl ester of Ampicillin Beta-lactam (penicillin) 1970 Preclinical
1032 Benzoyloxymethyl ester of Ampicillin Beta-lactam (penicillin) 1970 Preclinical
1033 7-Methoxy Cephalosporin Derivatives Beta-lactam (cephalosporin) 1973 Preclinical
1034 Verdamicin Aminoglycoside 1993 Preclinical
1036 Novel aminoglycosides from garamine Aminoglycoside 1974 Preclinical
1038 A2315A (madumycin II) Virginiamycin 1974 Preclinical
1039 Cefazaflur, SKF 59962 Beta-lactam (cephalosporin) 1974 Preclinical
1040 FR10612 Beta-lactam (cephalosporin) 1974 Preclinical
1042 Antibiotic XK-88-1 Aminoglycoside 1975 Preclinical
1043 Seldomycin factor 2 Aminoglycoside 1975 Preclinical
1044 Seldomycin factor 3 Aminoglycoside 1975 Preclinical
1045 Seldomycin factor 5 Aminoglycoside 1975 Preclinical
1046 Nocardin Beta-lactam (monobactam) 1975 Phase 4
1047 Fludalanine/pentizadone D-alanine racemase inhibitor 1975 Preclinical
1048 Pirbenicillin Beta-lactam (penicillin) 1975 Preclinical
1049 PC-455 Beta-lactam (penicillin) 1975 Preclinical
1050 Apalcillin (PC-904) Beta-lactam (penicillin) 1975 Preclinical
1051 CP-32,656 Ansamycin 1976 Preclinical
1052 Feldamycin Aminoglycoside 1976 Preclinical
1053 Nojirimycin Aminoglycoside 1976 Preclinical
1054 Etheromycin Aminoglycoside 1976 Preclinical
1055 Narasin Diterpene glycoside 1976 Preclinical
1056 A35512 complex, including A35512B Glycopeptide 1977 Preclinical
1057 Thiacycline Tetracycline 1977
1058 EMD32412 Beta-lactam (penicillin) 1977 Preclinical
1059 Epithienamycin Beta-lactam (carbapenem) 1977
1060 Butikacin Aminoglycoside 1977 Preclinical
1061 Cefsulodin Beta-lactam (cephalosporin) 1977 Phase 4
1062 Sulbactam + Carbenicillin Drug combination: beta-lactam (Penicillin) + beta-lactamase inhibitor 1978 Preclinical
1063 Indanomycin Ionophore 1978
1064 Enocin Natural product antibiotic 1978
1065 Dipeptide variants of Alafosfalin Phosphonodipeptide 1979 Preclinical
1066 Alafosfalin Phosphonodipeptide 1979 Preclinical
1067 CI-867 Beta-lactam (penicillin) 1979 Preclinical
1068 SCH 24893 Phenicol 1979 Preclinical
1069 SCH 25393 Phenicol 1979 Preclinical
1070 SCH 24298 Phenicol 1979 Preclinical
1071 Propikacin Aminoglycoside 1979 Preclinical
1072 DJ 6783 Quinolone 1979 Preclinical
1073 CP-47,433 Polycyclic ether antibiotic 1979 Preclinical
1074 CP-47,434 Polycyclic ether antibiotic 1979 Preclinical
1075 Glysperin complex A Atypical aminoglycoside 1980 Preclinical
1076 Glysperin complex B Atypical aminoglycoside 1980 Preclinical
1077 Glysperin complex C Atypical aminoglycoside 1980 Preclinical
1078 MS-19-Q Macrolide 1980 Preclinical
1079 Noboritomycin A Halogen containing polyether antibiotic 1980
1080 EMD 39734 Beta-lactam 1980
1081 Carpetimycin A Carbapenem (with beta-lactamase inhibitor properties) 1980
1082 Carpetimycin B Carbapenem (with beta-lactamase inhibitor properties) 1980
1083 E-0702 antibiotic Beta-lactam 1981
1084 Lysinomicin Aminoglycoside 1981
1087 SK&F 88070 Beta-lactam 1981
1088 Cefatiolene Beta-lactam 1981
1089 FCE21420 Beta-lactam 1981
1090 Thiosporamicin Thiostrepton 1982 Preclinical
1091 Maduramicin Polyether antibiotic 1982 Preclinical
1092 X-14868B Polyether antibiotic 1982 Preclinical
1093 X-14868C Polyether antibiotic 1982 Preclinical
1094 X-14868D Polyether antibiotic 1982 Preclinical
1095 X-14868G Polyether antibiotic 1986 Preclinical
1096 X-14868H Polyether antibiotic 1986 Preclinical
1097 Cationomycin Polyether antibiotic 1982 Preclinical
1098 L-681,217 Efrotomycin 1982 Preclinical
1099 Cefpimizole Beta-lactam 1982
1100 Sch 29482 Beta-lactam 1982 Phase 1
1102 OA-6129 D + E Beta-lactam (carbapenem) 1982 Preclinical
1103 Pluracidomycin Beta-lactam (carbapenem) 1982
1104 L-640876 Beta-lactam (cephalosporin) 1982
1105 SQ 81,377 Beta-lactam (monobactam) 1982
1106 Sarafloxacin Quinolone 1984 Phase 4
1109 Chlorocardicin Beta-lactam 1984 Preclinical
1111 LY171217 Beta-lactam (cephalosporin) 1984 Preclinical
1112 Antibiotic 87-351 Aminoglycoside 1984 Preclinical
1113 CGP 17520 Beta-lactam (cephalosporin) 1984 Preclinical
1114 DN-9550 Beta-lactam (cephalosporin) 1984 Preclinical
1115 SCH 34343 Beta-lactam (cephalosporin) 1984 Preclinical
1116 Spenolimycin Aminocyclitol 1984 Preclinical
1117 Biphenomycin A Peptide antibiotic 1984 Preclinical
1118 Biphenomycin B Peptide antibiotic 1984 Preclinical
1119 Ibafloxacin Quinolone 1984 Preclinical
1120 CL 118523 Beta-lactam (cephalosporin) 1984 Preclinical
1121 3’-quaternary ammonium Cephalosporins Beta-lactam (cephalosporin) 1984 Preclinical
1122 Tigemonam Beta-lactam (monobactam) 1985 Preclinical
1123 Formidacillin Beta-lactam 1985 Preclinical
1124 AT-3765 Quinolone 1985 Preclinical
1125 LY164846 Beta-lactam (cephalosporin) 1985 Preclinical
1126 M119-a Macrolide 1985 Preclinical
1127 SC-44914 Quinoxaline 1991 Preclinical
1128 E-4695 Quinolone 1991 Preclinical
1129 HSR-501 Quinolone 1991 Preclinical
1130 Sanfetrinem cilexetil Beta-lactam 1992 Phase 2
1131 Fluoroshikimic acid Aromatase inhibitor 1993 Preclinical
1132 E 1101 Beta-lactam (cephalosporin) 1993 Preclinical
1133 SYN987 Quinolone 1993 Preclinical
1134 BMS-180680 Beta-lactam (monobactam) 1994 Phase 2
1135 DZ-2640 Beta-lactam (carbapenem) 1995 Preclinical
1136 Fandofloxacin Fluoroquinolone 1995 Preclinical
1137 SYN 1903 Beta-lactamase inhibitor 1995 Preclinical
1138 MEN 10700 Beta-lactam (penem) 1998 Preclinical
1139 Cethromycin Ketolide 1998 Preclinical (suspended for Plague ad melidiosis)
1140 AY-60042 Tetracycline 1961 Preclinical
1142 Antibiotic 19A 1961 Preclinical
1143 Chalcomycin Macrolide (16-membered macrolide) 1961 Preclinical
1144 Narangomycin 1961 Preclinical
1145 levopropylcillin Beta-lactam (penicillin) 1961 Preclinical
1146 Wy-3206 Beta-lactam (penicillin) 1961 Preclinical
1148 SKF 12141 (2-biphenyl penicillin) Beta-lactam (penicillin) 1961 Preclinical
1149 AS17665 Nitrofuran 1962 Preclinical
1150 Bluensomycin Aminoglycoside 1962 Preclinical
1151 N-(5-nitro furfurylidene)-1-amino-2-imidazolidinone Nitrofuran 1963 Preclinical
1152 Nifurprazine Nitrofuran 1963 Preclinical
1153 Stravidin Antimicrobial peptide (biotin antimetabolie) 1963 Preclinical
1154 Neutramycin Macrolide 1963 Preclinical
1155 Sarganin Natural product antibiotic 1963 Preclinical
1156 Chonalgin Natural product antibiotic 1963 Preclinical
1158 Almarcetin Natural product antibiotic 1964 Preclinical
1159 Seligocidin Natural small molecule 1964 Preclinical
1160 U-22956 Aminoglycoside 1964 Preclinical
1161 MSD-819 1968 Preclinical
1163 BL-S 217 Beta-lactam (cephalosporin, first generation) 1971 Preclinical
1164 Maridomycin Macrolide 1971 Preclinical
1165 CP-53,607 Polyether ionophore 1983 Preclinical
1166 KY-101 Beta-lactam (cephalosporin, second generation) 1983 Preclinical
1167 KY-107 Beta-lactam (cephalosporin, second generation) 1983 Preclinical
1168 KY-109 Beta-lactam (cephalosporin, second generation) 1983 Preclinical
1169 LL-D4207 1986 Preclinical
1171 RU 44790 Beta-lactam (monobactam) 1986 Preclinical
1172 Pyrroxamycin Pyrrolomycin 1986 Preclinical
1174 A-65636 Anthramycin 1987 Preclinical
1175 Endusamycin Polycyclic Ether 1987 Preclinical
1176 Ro-239424 Beta-lactam (fluoroquinolone-cephalosporin) 1988 Preclinical
1177 PD 117596-2 Fluoroquinolone 1988 Preclinical
1178 LY249902 Beta-lactam (cephalosporin, carbacephem) 1989 Preclinical
1179 MT 0703S Beta-lactam (cephalosporin) 1989 Preclinical
1180 Ro 09-1428 Beta-lactam (cephalosporin) 1989 Preclinical
1181 E19085A 1990 Preclinical
1182 Enduracidin Cell-wall biosynthesis inhibitor 1970 Preclinical
1183 Cetocycline (Chelocardin/Cetotetrin) Tetracycline 1970 Preclinical
1184 Ficellomycin Aziridine 1976 Preclinical
1185 Zoliflodacin Bacterial topoisomerase inhibitor 2014 Phase 3
1186 Faropenem medoxomil Beta-lactam 1995 Phase 3 (suspended)
1188 MGB-BP-3 DNA synthesis inhibitor 2015 Phase 2 (NCT03824795)
1189 CB-618 Beta-lactamase inhibitor 2015 Phase 1
1190 TXA-709, active metabolite TXA-707 FtsZ inhibitor 2015 Phase 1
1192 ACT 387042 Bacterial topoisomerase inhibitor 2015 Preclinical
1193 ACT-292706 Bacterial topoisomerase inhibitor 2015 Preclinical
1194 Danirixin CXCR2 antagonist 2015 Phase 2
1195 ML302F Beta-lactamase inhibitor (metallo-beta lactamase) 2015 Preclinical
1196 FKI-6801 Beta-lactamase inhibitor (metallo-beta lactamase) 2015 Preclinical
1197 HT-06 Beta-lactam (cephalosporin, carbacephem [loracarbef-conjugate]) 2015 Preclinical
1198 RPX7381 Beta-lactamase inhibitor (carbapenemase inhibitor) 2015 Preclinical
1199 CA-824 Polymyxin 2015 Preclinical
1200 CA-900 Polymyxin 2015 Preclinical
1201 CA-1049 Polymyxin 2015 Preclinical
1202 MiBIECT Oxazolidinone 2015 Preclinical
1203 P300847 Pyridone 2015 Preclinical
1204 HT-10 Lipopeptide-siderophore conjugate 2015 Preclinical
1205 AM-1977 Quinolone 2015 Preclinical
1206 REDX04139 Bacterial topoisomerase inhibitor 2015 Preclinical
1207 REDX05604 Bacterial topoisomerase inhibitor 2015 Preclinical
1208 APY281 (aryl myxopyronin class) 2016 Preclinical
1209 CSE-1034 Beta-lactam 2004 Phase 3 (Clinical Trial)
1210 Avarofloxacin Fluoroquinolone 2008 Phase 2 (NCT01128530)
1211 CS-4771 2014 Phase 1
1212 DS-8587 Fluoroquinolone 2014 Phase 1
1213 DSTA4637S Antibody-antibiotic conjugate Phase 1
1214 MET-2 Probiotic Phase 1
1215 LFF571 Antimicrobial peptide Phase 2
1216 Cefilavacin, TD-1792 Glycopeptide-cephalosporin heterodimer Phase 3
1218 Meropenem + Nacubactam (OP0595/ RG6080) Drug combination: beta-lactam (carbapenem) + beta-lactamase inhibitor (diazabicyclooctane) Phase 1
1219 ETX2514SUL (Sulbactam + ETX2514) Drug combination: beta-lactam (carbapenem ) + beta-lactam (sulbactam) + beta-lactamase inhibitor (diazabicyclooctane) Phase 2
1220 Imipenem with cilastatin Beta-lactam (thienamycin) Approved by FDA in 1985
1221 Cefepime/VNRX-5133 Beta-lactamase inhibitor (broad spectrum) Phase 2
1222 AIC499 Beta-lactam (monobactam) Phase 2
1224 SPR994 Beta-lactam (carbapenem) Phase 3
1225 BOS 228 Beta-lactam (monobactam) Phase 2
1226 OPS-2071 Quinolone Phase 2
1227 Zifanocycline Tetracycline Phase 1
1228 SPR741 Polymyxin Phase 1
1229 GSK-3342830, GSK3342830 Beta-lactam (cephalosporin) Phase 1
1230 Zidebactam + Cefepime Beta-lactam + beta-lactamase inhibitor Phase 3 (NCT04979806)
1231 Ibezapolstat DNA synthesis inhibitor Phase 2
1232 Upleganan Polymyxin Phase 1
1234 Debio1453 Fatty acid synthesis inhibitor (FabI inhibitor) Preclinical
1235 GYROX Bacterial topoisomerase inhibitor Phase 1
1237 ETX0282CPDP (ETX0282 + cefpodoxime) Beta-lactam (cephalosporin) Phase 1
1239 FG-LpxC-LUNG Lipopolysaccharide synthesis inhibitor (LpxC inhibitor) Preclinical
1240 FG-LpxC-UTI Lipopolysaccharide synthesis inhibitor (LpxC inhibitor) Preclinical
1241 TopESKAPE Bacterial topoisomerase inhibitor Preclinical
1242 MRX-8 Polymyxin Phase 1 (NCT04649541)
1245 RC-01, T-1228 Lipopolysaccharide synthesis inhibitor (LpxC inhibitor) Phase 1
1246 SMT-571 (DDS-01 Series) Preclinical
1247 VNRX-PBP Cell-wall synthesis inhibitor (beta-lactamase resistant PBP inhibitor) Preclinical
1248 MDN-0207 Antimicrobial peptide (glycosylated lanthipeptide) Preclinical
1249 Fosfomycin Phosphonic acid antibacterial Approved by FDA in 1996
1250 Minocycline Tetracycline Approved by FDA in 1992
1252 RX-P2382 Pyrrolocytosine 2018 Preclinical
1253 Exebacase, CF-301 Bacteriophage lysin 2015 Phase 2
1254 CRS0540 PolC inhibitor (thiadiazole urea derived) 2019 Preclinical
1255 Apigenin Natural flavonoid Preclinical
1256 Chrysin Natural flavonoid Preclinical
1257 Kaempferol Natural flavonoid Preclinical
1258 Hesperetin Natural flavonoid Preclinical
1259 MBN-101 2015 Phase 2
1260 AuC1 (gold(III) complex) Gold(III) complex 2019 Preclinical
1261 DA-7310 Lipopolysaccharide synthesis inhibitor (LpxC inhibitor) Preclinical
1263 Tebipenem Beta-lactam 2009 Phase 3
1264 WB1 2-trifluoroacetonylbenzoxazole ligand 2019 Preclinical
1265 WB2 2-trifluoroacetonylbenzoxazole ligand 2019 Preclinical
1266 W3 2-trifluoroacetonylbenzoxazole ligand 2019 Preclinical
1267 Ivermectin/Colistin 2019 Preclinical
1268 Lysin GN123/Imipenem 2019 Preclinical
1269 Cycloberberine analogue 5b 13-substituted cycloberberine derivative 2019 Preclinical
1270 Cycloberberine analogue 5w 13-substituted cycloberberine derivative 2019 Preclinical
1271 AKAO-LpxC Lipopolysaccharide synthesis inhibitor (LpxC inhibitor) 2017 Preclinical
1272 Next-Generation AG Aminoglycoside Preclinical
1273 Helical AMP Antimicrobial peptide Preclinical
1274 NBTI Bacterial topoisomerase inhibitor Preclinical
1275 AGN-BL Beta-lactam Preclinical
1276 VIS705 Antibody-drug conjugate Preclinical
1277 P128 Bacteriophage lysin 2017 Preclinical
1278 Zidebactam Beta-lactamase inhibitor 2017 Phase 1
1279 NXL-105 Cell-wall synthesis inhibitor (PBP2 inhibitor) 2019 Preclinical
1280 ETX'991 Cell-wall synthesis inhibitor (PBP3 inhibitor) 2019 Preclinical
1281 ETX'678 Cell-wall synthesis inhibitor (PBP3 inhibitor) 2019 Preclinical
1282 ETX'054 Cell-wall synthesis inhibitor (PBP3 inhibitor) 2019 Preclinical
1283 LL-37 Antimicrobial peptide (cationic, human cathelicidin) 2013 Preclinical
1284 Melittin Antimicrobial peptide (cationic, cecropin(1-7)-melittin A(2-9) amide) 2019 Preclinical
1285 Magainin-II Antimicrobial peptide (cationic) 1990
1286 Nisin Antimicrobial peptide (cationic) 2019 Preclinical
1289 Ethyl bromopyruvate Derivative of 3-bromo-pyruvic acid (3- BPA) 2009 Preclinical
1290 IARR-mBjAMP1 Antimicrobial peptide (derivate of mBjAMP1) 2018 Preclinical
1291 IARR-Anal10 Antimicrobial peptide (derivate of mBjAMP1) 2018 Preclinical
1292 Ellagic acid Naturally occurring dietary polyphenol 2005 Preclinical
1293 pepR Antimicrobial peptide (viral-derived peptide) 2015 Preclinical
1294 NAB815 Polymyxin 2017 Preclinical
1295 CAMP113 Polymyxin 2018 Preclinical
1296 CAMP207 Polymyxin 2018 Preclinical
1297 ALX-009 (Hypothiocyanite/Lactoferrin) Combination of bovine lactoferrin and hypothiocyanite 2018 Preclinical
1298 POL7001 Lipopolysaccharide synthesis inhibitor (LptD inhibitor) 2016 Preclinical
1299 DA-7010 Aminoacyl-tRNA synthetase inhibitor (leucyl-tRNA synthetase [LeuRs] inhibitor) 2017 Preclinical
1300 Seleno compound 3 Symmetric di(selenoester)pyridine 2017 Preclinical
1301 M33 Antimicrobial peptide 2017 Preclinical
1302 REDX08106 Bacterial topoisomerase inhibitor 2017 Preclinical
1303 CSA-142 Ceragenin 2017 Preclinical
1304 CSA-192 Ceragenin 2017 Preclinical
1305 LN-1-255 Beta-lactamase inhibitor (inhibitor of class D carbapenemases of A. baumannii) 2017 Preclinical
1306 Novarifyn Antimicrobial peptide 2017 Preclinical
1307 CD201 Lipopolysaccharide-binding immunotherapy agent 2017 Preclinical
1308 ASN-4 Antibody (monoclonal antibody [mAb]) 2017 Preclinical
1309 Salvecin Antibody (monoclonal antibody [mAb]) Phase 3
1310 Aerucin Antibody (monoclonal antibody [mAb]) Phase 2
1311 Omodenbamab Antibody (monoclonal antibody [mAb]) Phase 2
1312 ASN-100 Antibody (monoclonal antibody [mAb]) Phase 2
1313 Sibofimloc Phase1
1314 Chinfloxacin Fluoroquinolone 2012 Phase 1
1315 Antofloxacin Fluoroquinolone 2008 Phase 2
1316 PFK-158 Glycolytic inhibitor Phase 1
1317 Diacerein Anthraquinone Phase 4
1318 DS86760016 Aminoacyl-tRNA synthetase inhibitor (leucyl-tRNA synthetase [LeuRs] inhibitor) Preclinical
1319 Indolmycin Aminoacyl-tRNA synthetase inhibitor (tryptophanyl-tRNA synthetase [TrpS] inhibitor) 1980 Preclinical
1320 Lactivicin Cell-wall synthesis inhibitor (non-beta-lactam antibiotic) 1986 Preclinical
1321 BVL-GSK098 2009 Phase 2
1322 Thiram and Disulfiram 2017 Preclinical
1323 Niclosamide 2018 Preclinical
1326 Ceftriaxone and Cefotaxime Beta-lactam (cephalosporin) 1987 Preclinical
1327 Human Defensin Antimicrobial peptide 1997 Preclinical
1328 ZY354 2019 Preclinical
1329 ZTI-01 (Fosfomycin for Injection) Phosphonic acid antibacterial Phase 4
1330 Bac7(1–35) Antimicrobial peptide Preclinical
1331 N2,N4-Disubstituted Quinazoline-2,4-Diamines Quinazoline Preclinical
1332 Poly (acetyl, arginyl) glucosamine (PAAG) is Cationic glycopolymer Preclinical
1333 Doxercalciferol Preclinical
1334 N-acetylcysteine Thiol antioxidant 1993 Preclinical
1335 Celecoxib COX-2 inhibitor 1999 Approved by FDA in 1998
1336 IITR06144 Nitrofuran 2019 Preclinical
1337 Bronopol Membrane-active agent (antibiofilm) 1978 Phase 4
1338 Bronidox Membrane-active agent (antibiofilm) 1986 Phase 4
1339 Mecillinam Amidinopenicillin 1972 Approved by FDA in 1984
1340 Pivmecillinam (Prodrug of Amdinocillin) Beta-lactam (penicillin) 1975 Approved by FDA in 2024
1341 Temocillin Beta-lactam (penicillin) 1982 Phase 4
1342 Azithromycin Macrolide (azalide) 1980 Approved by FDA in 2005
1343 Rafoxanide Salicylanilide 2018 Preclinical
1344 LMB-1 Beta-lactamase inhibitor (metallo-beta-lactamas) 2018 Preclinical
1345 Sutezolid Oxazolidinone 1996 Preclinical
1347 Tridecaptin M Lipopeptide 2019 Preclinical
1349 WAP-8294A1 Cyclodepsipeptide 1997 Preclinical
1350 Lotilibcin Cyclodepsipeptide 1997 Preclinical
1351 WAP-8294A4 Cyclodepsipeptide 1997 Preclinical
1352 IID572 Beta-lactamase inhibitor Preclinical
1353 IID572 + Piperacillin Drug combination: beta-lactam + beta-lactamase inhibitor Preclinical
1354 [S,S]-ethylenediamine-N,N′-disuccinic acid Beta-lactamase inhibitor (metallo-beta-lactamas) Preclinical
1355 Diphenyleneiodonium chloride NADH inhibitor Preclinical
1356 Acidocin 4356 Antimicrobial peptide Preclinical
1357 AA139-PNP Antimicrobial peptide 2020 Preclinical
1358 AA139-MCL Antimicrobial peptide 2020 Preclinical
1359 PQ401 Diarylurea derivative 2020 Preclinical
1360 Pin2[G] Antimicrobial peptide (host defense peptide) 2020 Preclinical
1361 FA1 Antimicrobial peptide (host defense peptide) 2020 Preclinical
1362 RB1 2020 Preclinical
1363 CB1 2020 Preclinical
1364 RB16 2020 Preclinical
1365 RB6 2020 Preclinical
1366 IB1 2020 Preclinical
1367 Monosulfactam 0073 Monosulfactam 2020 Preclinical
1368 Thymol Natural small molecule Phase 2
1369 Carvacrol Natural small molecule Preclinical
1370 trans-Cinnamaldehyde Natural small molecule Phase 4
1372 CORM-3 Carbon-monoxide releasing molecule 2003 Preclinical
1373 NU-6027 Cyclin dependant kinase-2 inhibitor/ ATR inhibitor 2011 Preclinical
1374 SPR1205 Polymixin B analogue 2019 Preclinical
1375 SPR946 Polymyxin E analogue 2019 Preclinical
1376 Pyrrolomycin C Natural product antibiotic 1983 Preclinical
1377 Pyrrolomycin D Natural product antibiotic 1983 Preclinical
1378 Pyrrolomycin I Natural product antibiotic 2019 Preclinical
1379 Pyrrolomycin J Natural product antibiotic 2019 Preclinical
1380 Polymyxin B Polymyxin 1964 Approved by FDA in 1994
1381 Romo1 Mitochondrial protein 2018 Preclinical
1382 AMPR-11 Antimicrobial peptide 2020 Preclinical
1383 Xeruborbactam Beta-lactamase inhibitor 2020 Phase 1 (NCT04380207)
1384 HT61 Quinoline 2020 Preclinical
1385 GC-072 Oxoquinolizine 2019 Preclinical
1386 Paenipeptin analogue 1 Lipopeptide 2018 Preclinical
1387 Paenipeptin analogue 15 Lipopeptide 2018 Preclinical
1388 Quinazolinone 1 Quinazolinone (PBP1 and 2a inhibitor) 2019 Preclinical
1389 Quinazolinone 2 Quinazolinone (PBP1 and 2a inhibitor) 2019 Preclinical
1390 Quinazolinone 3 Quinazolinone (PBP1 and 2a inhibitor) 2019 Preclinical
1391 Quinazolinone 4 Quinazolinone (PBP1 and 2a inhibitor) 2019 Preclinical
1392 Quinazolinone 5 Quinazolinone (PBP1 and 2a inhibitor) 2019 Preclinical
1394 TBAJ-876 Diarylquinoline 2019 Phase 2
1395 DAV131A Antibiotic adjuvant 2017 Preclinical
1396 TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl) Nitroxide 2019 Preclinical
1397 CTEMPO (4-carboxy-2,2,6,6-tetramethylpiperidin-1-yloxyl) Nitroxide 2019 Preclinical
1398 CTMIO (5-carboxy-1,1,3,3-tetramethylisoindolin-2-yloxyl) Nitroxide 2019 Preclinical
1399 cipro-PROXYL Nitroxide 2017 Preclinical
1400 cipro-TEMPO Nitroxide 2017 Preclinical
1401 cipro-TMIO Nitroxide 2017 Preclinical
1402 Fluoroquinolone- TEMPO Nitroxide 2019 Preclinical
1403 Fluoroquinolone- TEMPMe Nitroxide 2019 Preclinical
1404 3-O-methyl-butylgallate Natural product antibiotic 2019 Preclinical
1405 3-O-methyl-hexylgallate Natural product antibiotic 2019 Preclinical
1406 3-O-methyl-octylgallate Natural product antibiotic 2019 Preclinical
1408 Thioridazine Phenothiazine Approved by FDA in 1962
1409 MEDI6389 (MEDI4893*, SAR114 and SAN481) Antibody (monoclonal antibody [mAb]) 2019 Preclinical
1410 Bedaquiline (Sirturo) Diarylquinoline 2004 Approved by FDA in 2012
1411 Cefepime + Taniborbactam Beta-lactam + beta-lactamase inhibitor (boronate) Phase 3
1412 Lee-3464 Disubstituted urea 2019 Preclinical
1413 F2619-0556 Sulfonamide 2019 Preclinical
1414 F1374-0037 Oxadiazole 2019 Preclinical
1415 p-Anisaldehyde Natural product antibiotic Preclinical
1417 1,2,4-Oxadiazole derivatives 1,2,4-oxadiazole 2015 Preclinical
1418 JRH-24-1 1,2,4-oxadiazole 2018 Preclinical
1420 Clofazimine Riminophenazine 1986 Approved by FDA in 1986
1421 Clarithromycin Macrolide 1980 Approved by FDA in 1991
1422 GSK3036656 Aminoacyl-tRNA synthetase inhibitor (leucyl-tRNA synthetase [LeuRs] inhibitor) 2019 Phase 2
1423 WCK 4234 Beta-lactamase inhibitor (diazabicyclooctane) 2017 Preclinical
1424 Mutacin B-Ny266 Antimicrobial peptide (bacteriocin, lantibiotic) 2020 Preclinical
1425 Quabodepistat 3,4-dihydrocarbostyril derivative 2020 Phase 2 (NCT05971602)
1426 Actifensin Antimicrobial peptide (bacteriocin) 2019 Preclinical
1427 Arachidonic Acid Polyunsaturated fatty acid 2019 Preclinical
1428 Pyrazinamide Prodrug 1972 Approved by FDA in 1971
1429 Verapamil Efflux pump inhibitor (ABC family inhibitor) 1981
1430 GH12 Antimicrobial peptide 2020 Preclinical
1431 DIBI 3-hydroxypyridin-4-one chelator 2018 Preclinical
1432 GI262866A Quinazoline 2019 Preclinical
1433 GI261520A Quinazoline 2019 Preclinical
1434 EJMCh4 {5-bromo-2-(2-cyclohexylethyl)-1H-benzo[d]imidazole} 1H-benzo[d]imidazole derivative 2015 Preclinical
1435 EJMCh6 {2-(2-cyclohexylethyl)-5,6-dimethyl-1H-benzo[d]imidazole} 1H-benzo[d]imidazole derivative 2015 Preclinical
1436 2,5-dimethyl-4-sulfamoylfuran-3-carboxylic acid (SFC) Beta-lactamase inhibitor (metallo-beta-lactamase inhibitor) 2020 Preclinical
1437 2,5-diethyl-1-methyl-4-sulfamoylpyrrole-3-carboxylic acid (SPC) Beta-lactamase inhibitor (metallo-beta-lactamase inhibitor) 2020 Preclinical
1438 Walrycin B 2010
1439 AZD9742 Bacterial topoisomerase inhibitor 2009 Phase 1
1440 AZD5099 Pyrrolamide 2011 Phase 1
1441 TP-2758 Tetracycline 2011 Phase 1 (Eudract number 2011-001204-35)
1442 Posizolid Oxazolidinone 2004 Phase 2 (NCT01516203)
1443 Lanopepden Peptide deformylase inhibitor 2009 Phase 2
1444 Ceftaroline Beta-lactam (cephalosporin) 2008 Approved by FDA in 2010; Approved for pediatric use in 2016
1445 DPK-060, CD-1 Antimicrobial peptide 2017 Preclinical
1446 IMX 942 Immune defense activator 2009 Preclinical
1447 Caffeic Acid Phenethyl Acid Natural small molecule 1979 Preclinical
1448 AIP-1 Antimicrobial peptide Preclinical
1449 Nitazoxanide Thiazolide 1980 Approved by FDA in 2005
1450 Rifampicin Rifamycin 1965 Approved by FDA in 1971
1451 Linezolid Oxazolidinone 1990 Approved by FDA in 2000
1452 Isoniazid Cell-wall synthesis inhibitor 1952 Approved by FDA in 1983
1453 Redx03863 Bacterial topoisomerase inhibitor 2020 Preclinical
1454 Redx04739 Bacterial topoisomerase inhibitor 2020 Preclinical
1455 Inhibitor Peptide P1 Beta-lactamase inhibitor (metallo-beta lactamase) 2020 Preclinical
1456 Inhibitor Peptide P2 Beta-lactamase inhibitor (metallo-beta lactamase) 2020 Preclinical
1457 Inhibitor Peptide P3 Beta-lactamase inhibitor (metallo-beta lactamase) 2020 Preclinical
1458 Inhibitor Peptide P4 Beta-lactamase inhibitor (metallo-beta lactamase) 2020 Preclinical
1459 Inhibitor Peptide P5 Beta-lactamase inhibitor (metallo-beta lactamase) 2020 Preclinical
1460 Inhibitor Peptide P6 Beta-lactamase inhibitor (metallo-beta lactamase) 2020 Preclinical
1461 Inhibitor Peptide P7 Beta-lactamase inhibitor (metallo-beta lactamase) 2020 Preclinical
1462 Inhibitor Peptide P8 Beta-lactamase inhibitor (metallo-beta lactamase) 2020 Preclinical
1463 Inhibitor Peptide P9 Beta-lactamase inhibitor (metallo-beta lactamase) 2020 Preclinical
1464 Macfarlandin D Natural product antibiotic 2020 Preclinical
1465 Macfarlandin F Natural product antibiotic 2020 Preclinical
1466 Macfarlandin G Natural product antibiotic 2020 Preclinical
1467 Macfarlandin H Natural product antibiotic 2020 Preclinical
1468 Steffimycin E Steffimycin 2020 Preclinical
1469 Streptovertimycin A Fasamycin-type polyketide 2020 Preclinical
1470 Streptovertimycin B Fasamycin-type polyketide 2020 Preclinical
1471 Streptovertimycin C Fasamycin-type polyketide 2020 Preclinical
1472 Streptovertimycin D Fasamycin-type polyketide 2020 Preclinical
1473 Streptovertimycin E Fasamycin-type polyketide 2020 Preclinical
1474 Streptovertimycin F Fasamycin-type polyketide 2020 Preclinical
1475 Streptovertimycin G Fasamycin-type polyketide 2020 Preclinical
1476 Streptovertimycin H Fasamycin-type polyketide 2020 Preclinical
1477 Methyl ferrocenyl chalcone Flavonoid 2020 Preclinical
1478 Ethyl ferrocenyl chalcone Flavonoid 2020 Preclinical
1479 Propyl ferrocenyl chalcone Flavonoid 2020 Preclinical
1480 Butyl ferrocenyl chalcone Flavonoid 2020 Preclinical
1481 Pentyl ferrocenyl chalcone Flavonoid 2020 Preclinical
1482 Hexyl ferrocenyl chalcone Flavonoid 2020 Preclinical
1483 Heptyl ferrocenyl chalcone Flavonoid 2020 Preclinical
1484 Octyl ferrocenyl chalcone Flavonoid 2020 Preclinical
1485 Nonyl ferrocenyl chalcone Flavonoid 2020 Preclinical
1486 Decyl ferrocenyl chalcone Flavonoid 2020 Preclinical
1487 Benzyl Phenyl Sulfide derivative 5d Benzyl phenyl sulfide derivative 2020 Preclinical
1488 Benzyl Phenyl Sulfide derivative 5e Benzyl phenyl sulfide derivative 2020 Preclinical
1489 Benzyl Phenyl Sulfide derivative 5f Benzyl phenyl sulfide derivative 2020 Preclinical
1490 Benzyl Phenyl Sulfide derivative 5h Benzyl phenyl sulfide derivative 2020 Preclinical
1491 Benzyl Phenyl Sulfide derivative 5j Benzyl phenyl sulfide derivative 2020 Preclinical
1492 Closantel Salicylanilide 2019 Preclinical
1493 Oxyclozanide Salicylanilide 2019 Preclinical
1495 Dichlorophene Diarylmethane 2005 Preclinical
1496 Triclabendazole (Egaten) Benzimidazole 2019 Preclinical
1497 Nithiamide Acetamide 2005 Preclinical
1498 Ursolic Acid Triterpenoid 1920 Preclinical
1501 TZ40-J Polymyxin 2019 Preclinical
1502 TZ40-K Polymyxin 2019 Preclinical
1503 Pyridine-2-thiol 1-oxide sodium salt Synthetic small molecule 2019 Preclinical
1504 Metronidazole (Flagyl) Nitroimidazole 1960 Approved by FDA in 1995
1505 Vancomycin Glycopeptide 1956 Approved by FDA in 1986
1506 Ronidazole Nitroimidazole 2005 Preclinical
1507 Dimetridazole Nitroimidazole 2005 Preclinical
1508 Ornidazole Nitroimidazole 2016 Preclinical
1510 Secnidazole Nitroimidazole 2003 Preclinical
1511 7,8-dideoxygriseorhodin C Griseorhodin Preclinical
1512 Pentaminomycin C Cyclic pentapeptide Preclinical
1513 Teicoplanin Glycopeptide 1989 Phase 4
1514 Teicoplanin intermediate dicarbamate derivative (Analogue 4) Glycopeptide 2020 Preclinical
1515 Teicoplanin pseudoaglycone derivative (Analogue 5) Glycopeptide 2020 Preclinical
1516 Teicoplanin pseudoaglycon guanidine derivative 13a (diphenylmethyl ester) Glycopeptide 2020 Preclinical
1517 Teicoplanin pseudoaglycon guanidine derivative 13b (diphenylmethyl ester) Glycopeptide 2020 Preclinical
1518 Teicoplanin pseudoaglycon guanidine derivative 13c (diphenylmethyl ester) Glycopeptide 2020 Preclinical
1519 Teicoplanin pseudoaglycon guanidine derivative 13d (diphenylmethyl ester) Glycopeptide 2020 Preclinical
1520 Teicoplanin pseudoaglycon guanidine derivative 14a (Free C-Terminus) Glycopeptide 2020 Preclinical
1521 Teicoplanin pseudoaglycon guanidine derivative 14b (Free C-Terminus) Glycopeptide 2020 Preclinical
1522 Teicoplanin pseudoaglycon guanidine derivative 14c (Free C-Terminus) Glycopeptide 2020 Preclinical
1523 Teicoplanin pseudoaglycon guanidine derivative 14d (Free C-Terminus) Glycopeptide 2020 Preclinical
1524 Teicoplanin pseudoaglycon guanidine derivative 15a (Amide) Glycopeptide 2020 Preclinical
1525 Teicoplanin pseudoaglycon guanidine derivative 15b (Amide) Glycopeptide 2020 Preclinical
1526 Teicoplanin pseudoaglycon guanidine derivative 15c (Amide) Glycopeptide 2020 Preclinical
1527 Teicoplanin pseudoaglycon guanidine derivative 15d (Amide) Glycopeptide 2020 Preclinical
1528 Teicoplanin guanidine derivative 16b (Amide) Glycopeptide 2020 Preclinical
1529 Teicoplanin guanidine derivative 16e (Amide) Glycopeptide 2020 Preclinical
1530 Teicoplanin guanidine derivative 16f (Amide) Glycopeptide 2020 Preclinical
1533 Muraminomicin F MraY inhibitor (nucleoside antibiotic) 2019 Preclinical
1534 Muraminomicin G MraY inhibitor (nucleoside antibiotic) 2019 Preclinical
1535 Muraminomicin H MraY inhibitor (nucleoside antibiotic) 2019 Preclinical
1536 Muraminomicin Z1 MraY inhibitor (nucleoside antibiotic) 2019 Preclinical
1537 Muraminomicin Z2 MraY inhibitor (nucleoside antibiotic) 2019 Preclinical
1538 DS60182922 MraY inhibitor (nucleoside antibiotic) 2019 Preclinical
1539 DS14450354 MraY inhibitor (nucleoside antibiotic) 2019 Preclinical
1541 CPZEN-45 analog 1 Mycolyl arabinogalactan biosynthesis inhibitor 2019 Preclinical
1542 CPZEN-45 analog 2 Mycolyl arabinogalactan biosynthesis inhibitor 2019 Preclinical
1543 CPZEN-45 analog 3 Mycolyl arabinogalactan biosynthesis inhibitor 2019 Preclinical
1544 CPZEN-45 analog 4 Mycolyl arabinogalactan biosynthesis inhibitor 2019 Preclinical
1545 CPZEN-45 analog 5 Mycolyl arabinogalactan biosynthesis inhibitor 2019 Preclinical
1546 2-(pyrazol-1-yl)- thiazole Compound 1 Protein synthesis inhibitor 2019 Preclinical
1547 2-(pyrazol-1-yl)- thiazole Compound 2 Protein synthesis inhibitor 2019 Preclinical
1548 2-(pyrazol-1-yl)- thiazole Compound 3 Protein synthesis inhibitor 2019 Preclinical
1549 2-(pyrazol-1-yl)- thiazole Compound 4 Protein synthesis inhibitor 2019 Preclinical
1550 2-(pyrazol-1-yl)- thiazole Compound 5 Protein synthesis inhibitor 2019 Preclinical
1551 2-(pyrazol-1-yl)- thiazole Compound 6 Protein synthesis inhibitor 2019 Preclinical
1552 2-(pyrazol-1-yl)- thiazole Compound 7 Protein synthesis inhibitor 2019 Preclinical
1553 2-(pyrazol-1-yl)- thiazole Compound 8 Protein synthesis inhibitor 2019 Preclinical
1554 CXP18.6-012 PanK inhibitor 2019 Preclinical
1555 CXP18.6-013 PanK inhibitor 2019 Preclinical
1556 CXP18.6-014 PanK inhibitor 2019 Preclinical
1557 CXP18.6-017 PanK inhibitor 2019 Preclinical
1558 CXP18.6-069 PanK inhibitor 2019 Preclinical
1559 CXP18.6-047 PanK inhibitor 2019 Preclinical
1560 CXP18.6-057 PanK inhibitor 2019 Preclinical
1561 CXP18.6-064 PanK inhibitor 2019 Preclinical
1562 CXP14.18–028 PanK inhibitor 2019 Preclinical
1563 CXP14.18–005 PanK inhibitor 2019 Preclinical
1564 CXP14.26–007 PanK inhibitor 2019 Preclinical
1565 CXP14.18–037 PanK inhibitor 2019 Preclinical
1566 CXP14.18–038 PanK inhibitor 2019 Preclinical
1567 CXP14.18–034 PanK inhibitor 2019 Preclinical
1568 CXP14.18–012 PanK inhibitor 2019 Preclinical
1569 NPS-2143 CaSR antagonist 2001 Preclinical
1570 NPS-2143 derivative 19 CaSR antagonist 2019 Preclinical
1571 NPS-2143 derivative 20 CaSR antagonist 2019 Preclinical
1572 NPS-2143 derivative 21 CaSR antagonist 2019 Preclinical
1573 NPS-2143 derivative 22 CaSR antagonist 2019 Preclinical
1574 NPS-2143 derivative 23 CaSR antagonist 2019 Preclinical
1575 NPS-2143 derivative 24 CaSR antagonist 2019 Preclinical
1576 NPS-2143 derivative 25 CaSR antagonist 2019 Preclinical
1577 NPS-2143 derivative 26 CaSR antagonist 2019 Preclinical
1578 NPS-2143 derivative 27 CaSR antagonist 2019 Preclinical
1579 NPS-2143 derivative 28 CaSR antagonist 2019 Preclinical
1580 NPS-2143 derivative 29 CaSR antagonist 2019 Preclinical
1581 NPS-2143 derivative 30 CaSR antagonist 2019 Preclinical
1582 NPS-2143 derivative 31 CaSR antagonist 2019 Preclinical
1583 NPS-2143 derivative 32 CaSR antagonist 2019 Preclinical
1584 NPS-2143 derivative 33 CaSR antagonist 2019 Preclinical
1585 NPS-2143 derivative 34 CaSR antagonist 2019 Preclinical
1586 NPS-2143 derivative 35 CaSR antagonist 2019 Preclinical
1587 NPS-2143 derivative 36 CaSR antagonist 2019 Preclinical
1588 NPS-2143 derivative 37 CaSR antagonist 2019 Preclinical
1589 NPS-2143 derivative 38 CaSR antagonist 2019 Preclinical
1590 NPS-2143 derivative 39 CaSR antagonist 2019 Preclinical
1591 NPS-2143 derivative 43 CaSR antagonist 2019 Preclinical
1592 NPS-2143 derivative 44 CaSR antagonist 2019 Preclinical
1593 NPS-2143 derivative 48 CaSR antagonist 2019 Preclinical
1594 NPS-2143 derivative 49 CaSR antagonist 2019 Preclinical
1595 NPS-2143 derivative 50 CaSR antagonist 2019 Preclinical
1596 Aminobenzopentathiepine amide compound 13 2019 Preclinical
1597 Aminobenzopentathiepine amide compound 14 2019 Preclinical
1598 Aminobenzopentathiepine amide compound 15 2019 Preclinical
1599 Aminobenzopentathiepine amide compound 16 2019 Preclinical
1600 Aminobenzopentathiepine amide compound 17 2019 Preclinical
1601 Trifluoroacetamide analog compound 18 2019 Preclinical
1602 Trifluoroacetamide analog compound 19 2019 Preclinical
1603 Novel Phloroglucinol Derivative 1 2019 Preclinical
1604 Novel Phloroglucinol Derivative 2 2019 Preclinical
1605 Novel Phloroglucinol Derivative 3 2019 Preclinical
1606 Novel Phloroglucinol Derivative 4 2019 Preclinical
1607 Novel Phloroglucinol Derivative 5 2019 Preclinical
1608 Novel Phloroglucinol Derivative 6 2019 Preclinical
1609 Novel Phloroglucinol Derivative 7 2019 Preclinical
1610 Novel Phloroglucinol Derivative 8 2019 Preclinical
1611 Novel Phloroglucinol Derivative 9 2019 Preclinical
1612 Novel Phloroglucinol Derivative 10 2019 Preclinical
1613 Novel Phloroglucinol Derivative 11 2019 Preclinical
1614 Novel Phloroglucinol Derivative 12 2019 Preclinical
1615 2-thio-5-(tert-butyl)-6-azauracil Nucleoside analog 2019 Preclinical
1616 2-thio-5-phenyl-6-azauracil Nucleoside analog 2019 Preclinical
1617 5-(tert-butyl)-6-azauracil Nucleoside analog 2019 Preclinical
1618 5-phenyl-6-azauracil Nucleoside analog 2019 Preclinical
1619 2’-Deoxy-2-thio-5-phenyl-6-azauridine Nucleoside analog 2019 Preclinical
1620 2’-Deoxy-5-(tert-butyl)-6-azauridine Nucleoside analog 2019 Preclinical
1621 2’-Deoxy-5-phenyl-6-azauridine Nucleoside analog 2019 Preclinical
1622 2’-Deoxy-2-thio-5-(tert-butyl)-6-azauridine Nucleoside analog 2019 Preclinical
1623 Xenematide F Antimicrobial peptide (cyclic depsipeptide) 2019 Preclinical
1624 Xenematide G Antimicrobial peptide (cyclic depsipeptide) 2019 Preclinical
1625 Spectinamide Aminocyclitol 2019 Preclinical
1626 Aminomethyl Spectinomicin Aminocyclitol 2019 Preclinical
1627 Spectinomicin analog 1950 Aminocyclitol 2019 Preclinical
1628 Spectinomicin analog 1951 Aminocyclitol 2019 Preclinical
1629 Spectinomicin analog 2241 Aminocyclitol 2019 Preclinical
1630 Spectinomicin analog 2324 Aminocyclitol 2019 Preclinical
1631 Synthesized Azolylthioacetamide 1 Beta-lactamase inhibitor 2019 Preclinical
1632 Synthesized Azolylthioacetamide 2 Beta-lactamase inhibitor 2019 Preclinical
1633 Synthesized Azolylthioacetamide 3 Beta-lactamase inhibitor 2019 Preclinical
1634 Synthesized Azolylthioacetamide 4 Beta-lactamase inhibitor 2019 Preclinical
1635 Synthesized Azolylthioacetamide 5 Beta-lactamase inhibitor 2019 Preclinical
1636 Synthesized Azolylthioacetamide 6 Beta-lactamase inhibitor 2019 Preclinical
1637 Synthesized Azolylthioacetamide 7 Beta-lactamase inhibitor 2019 Preclinical
1638 Synthesized Azolylthioacetamide 8 Beta-lactamase inhibitor 2019 Preclinical
1639 Synthesized Azolylthioacetamide 9 Beta-lactamase inhibitor 2019 Preclinical
1640 Synthesized Azolylthioacetamide 10 Beta-lactamase inhibitor 2019 Preclinical
1641 Synthesized Azolylthioacetamide 11 Beta-lactamase inhibitor 2019 Preclinical
1642 Synthesized Azolylthioacetamide 12 Beta-lactamase inhibitor 2019 Preclinical
1643 Synthesized Azolylthioacetamide 13 Beta-lactamase inhibitor 2019 Preclinical
1644 Novel thiourea ligand HL Cell metabolism inhibitor 2019 Preclinical
1645 Novel thiourea ligand 1a Cell metabolism inhibitor 2019 Preclinical
1646 Novel thiourea ligand 1b Cell metabolism inhibitor 2019 Preclinical
1647 Novel thiourea ligand 1c Cell metabolism inhibitor 2019 Preclinical
1648 3,4-bis(arylthio)maleimide compound 3a 3,4-bis(arylthio)maleimide 2019 Preclinical
1649 3,4-bis(arylthio)maleimide compound 3b 3,4-bis(arylthio)maleimide 2019 Preclinical
1650 3,4-bis(arylthio)maleimide compound 3c 3,4-bis(arylthio)maleimide 2019 Preclinical
1651 3,4-bis(arylthio)maleimide compound 3d 3,4-bis(arylthio)maleimide 2019 Preclinical
1652 3,4-bis(arylthio)maleimide compound 3e 3,4-bis(arylthio)maleimide 2019 Preclinical
1653 3,4-bis(arylthio)maleimide compound 3f 3,4-bis(arylthio)maleimide 2019 Preclinical
1654 3,4-bis(arylthio)maleimide compound 3g 3,4-bis(arylthio)maleimide 2019 Preclinical
1655 Benzoxaborole derivative of azithromycin compound 7 Macrolide 2019 Preclinical
1656 Benzoxaborole derivative of azithromycin compound 13 Macrolide 2019 Preclinical
1657 Benzoxaborole derivative of azithromycin compound 14 Macrolide 2019 Preclinical
1658 Benzoxaborole derivative of azithromycin compound 15 Macrolide 2019 Preclinical
1659 Benzoxaborole derivative of azithromycin compound 16 Macrolide 2019 Preclinical
1660 Benzoxaborole derivative of azithromycin compound 17 Macrolide 2019 Preclinical
1661 Benzoxaborole derivative of azithromycin compound 18 Macrolide 2019 Preclinical
1662 Benzoxaborole derivative of azithromycin compound 19 Macrolide 2019 Preclinical
1663 Benzoxaborole derivative of azithromycin compound 20 Macrolide 2019 Preclinical
1664 Benzoxaborole derivative of azithromycin compound 21 Macrolide 2019 Preclinical
1665 Benzoxaborole derivative of azithromycin compound 22 Macrolide 2019 Preclinical
1666 Benzoxaborole derivative of azithromycin compound 23 Macrolide 2019 Preclinical
1667 Benzoxaborole derivative of azithromycin compound 24 Macrolide 2019 Preclinical
1668 Benzoxaborole derivative of azithromycin compound 25 Macrolide 2019 Preclinical
1669 Benzoxaborole derivative of azithromycin compound 26 Macrolide 2019 Preclinical
1670 Benzoxaborole derivative of azithromycin compound 27 Macrolide 2019 Preclinical
1671 Benzoxaborole derivative of azithromycin compound 28 Macrolide 2019 Preclinical
1672 Benzoxaborole derivative of azithromycin compound 29 Macrolide 2019 Preclinical
1673 Benzoxaborole derivative of azithromycin compound 30 Macrolide 2019 Preclinical
1674 Acremotin A Antimicrobial peptide (peptaibiotic) 2018 Preclinical
1675 Acremotin B Antimicrobial peptide (peptaibiotic) 2018 Preclinical
1676 Acremotin C Antimicrobial peptide (peptaibiotic) 2018 Preclinical
1677 Acremotin D Antimicrobial peptide (peptaibiotic) 2018 Preclinical
1678 XR586 Antimicrobial peptide (peptaibiotic) 2018 Preclinical
1679 Elloramycin Tetracenomycin 1990 Preclinical
1680 Tetracenomycin C Tetracenomycin 1979 Preclinical
1681 Tetracenomycin X Tetracenomycin Preclinical
1682 Ala-geninthiocin Antimicrobial peptide (thiopeptide) 2018 Preclinical
1683 Geninthiocin (Ala-geninthiocin analog) Antimicrobial peptide (thiopeptide) 2018 Preclinical
1684 Val-geninthiocin (Ala-geninthiocin analog) Antimicrobial peptide (thiopeptide) 2018 Preclinical
1686 Boromycin Polyether macrolide 2018 Preclinical
1687 CD437 Retinoid 2018 Preclinical
1688 CD1530 Retinoid 2018 Preclinical
1689 Albicidin Bacterial topoisomerase inhibitor 2019 Preclinical
1690 G0775 Type I signal peptidase inhibitor 2018 Preclinical
1691 Boeravirone B Efflux pump inhibitor 2017 Preclinical
1692 Curvulaide A Bicyclic polyketide Preclinical
1693 BRD4592 Tryptophan synthase inhibitor 2017 Preclinical
1694 hdMolluscidin Antimicrobial peptide 2016 Preclinical
1695 gcMolluscidin Antimicrobial peptide 2013 Preclinical
1696 Enaminone-grafted trithiocarbonate compound 3 Eaminone 2020 Preclinical
1697 Seysara (Sarecycline) Tetracycline 2020 Preclinical
1698 Pestiocandin Papulacandin 2018 Preclinical
1699 ChBp Antimicrobial peptide (choline binding polypeptide) 2018 Preclinical
1700 Mag(i+4)1,15(A9K,B21A,N22K,S23K) Antimicrobial peptide 2019 Preclinical
1701 Dialkylresorcinol semi-synthetic derivative 1 Dialkylresorcinol 2020 Preclinical
1702 Dialkylresorcinol semi-synthetic derivative 2 Dialkylresorcinol 2020 Preclinical
1703 Dialkylresorcinol semi-synthetic derivative 3 Dialkylresorcinol 2020 Preclinical
1704 Dialkylresorcinol semi-synthetic derivative 5 Dialkylresorcinol 2020 Preclinical
1705 Dialkylresorcinol semi-synthetic derivative 7 Dialkylresorcinol 2020 Preclinical
1706 Dialkylresorcinol semi-synthetic derivative 10 Dialkylresorcinol 2020 Preclinical
1707 Dialkylresorcinol semi-synthetic derivative 13 Dialkylresorcinol 2020 Preclinical
1708 Dialkylresorcinol semi-synthetic derivative 15 Dialkylresorcinol 2020 Preclinical
1709 Dialkylresorcinol semi-synthetic derivative 17 Dialkylresorcinol 2020 Preclinical
1710 Dialkylresorcinol semi-synthetic derivative 19 Dialkylresorcinol 2020 Preclinical
1711 Dialkylresorcinol semi-synthetic derivative 22 Dialkylresorcinol 2020 Preclinical
1712 Virstatin ToxT inhibitor 2005 Preclinical
1713 Quercitrin SrtA inhibitor 1996 Preclinical
1714 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 5 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1715 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 6 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1716 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 7 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1717 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 8 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1718 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 9 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1719 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 10 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1720 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 11 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1721 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 12 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1722 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 13 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1723 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 14 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1724 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 15 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1725 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 16 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1726 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 17 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1727 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 18 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1728 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 19 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1729 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 20 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1730 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 21 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1731 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 22 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1732 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 23 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1733 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 24 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1734 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivative 25 Naphthyl-substituted pyrazole-derived hydrazone 2020 Preclinical
1735 Raxibacumab Antibody (monoclonal antibody [mAb]) 2009 Approved by FDA in 2012
1736 Obiltoxaximab (Anthim) Antibody (monoclonal antibody [mAb]) 2005 Approved by FDA in 2016
1737 Bezlotoxumab, Zinplava Antibody (monoclonal antibody [mAb]) 2009 Approved by FDA in 2016
1738 AR-101 Antibody (monoclonal antibody [mAb]) 2020 Phase 3
1739 Shigamab Antibody (monoclonal antibody [mAb]) 2020 Phase 2
1740 mAb926 Antibody (monoclonal antibody [mAb]) 2020 Preclinical
1741 mAb475 Antibody (monoclonal antibody [mAb]) 2020 Preclinical
1742 Dehydrocrepenynic acid 2020 Preclinical
1743 2-Hexadecynoic acid 2020 Preclinical
1744 Tanzawaic acid A Bacterial conjugation inhibitor 2020 Preclinical
1745 Tanzawaic acid B Bacterial conjugation inhibitor 2020 Preclinical
1746 CHIR-1 Cagα ATPase inhibitor 2020 Preclinical
1747 ID7146 Antivirulence agent (T3SS) 2020 Preclinical
1748 Clioxanide Antivirulence agent (T3SS) 2020 Preclinical
1749 Caminoside A Glycolipid 2020 Preclinical
1750 R1015PM Antivirulence agent (T3SS) 2020 Preclinical
1751 Hopeaphenol Antivirulence agent (T3SS) 2020 Preclinical
1752 Licoflavonol Antivirulence agent (T3SS) 2020 Preclinical
1753 Goldinomycin Antivirulence agent (T3SS) 2020 Preclinical
1754 Farnesol pqsA inhibitor 2020 Preclinical
1755 Ajoene RsmY and RsmZ inhibitor 2020 Preclinical
1756 Patulin RhlR inhibitor 2020 Preclinical
1757 Savirin AgrA inhibitor 2020 Preclinical
1758 Clotrimazole PqsR inhibitor 2020 Preclinical
1759 Miconazole PqsR inhibitor 2020 Preclinical
1760 Clofoctol PqsR inhibitor 1981 Preclinical
1761 Chloptosin B 2021 Preclinical
1762 Chloptosin C 2021 Preclinical
1763 Cervinomycin C1 Natural product antibiotic (polycyclic xanthone) 2020 Preclinical
1764 Cervinomycin C2 Natural product antibiotic (polycyclic xanthone) 2020 Preclinical
1765 Cervinomycin C3 Natural product antibiotic (polycyclic xanthone) 2020 Preclinical
1766 Cervinomycin C4 Natural product antibiotic (polycyclic xanthone) 2020 Preclinical
1767 Termstrin A Anthraquinone 2020 Preclinical
1768 Termstrin B Anthraquinone 2020 Preclinical
1769 Termstrin C Anthraquinone 2020 Preclinical
1770 Termstrin D Anthraquinone 2020 Preclinical
1771 6-(pyrrolidin-2-yl)DAPG Alkaloid 2020 Preclinical
1772 6-(piperidin-2-yl)DAPG Alkaloid 2020 Preclinical
1773 Albiducin A Polyketide 2018 Preclinical
1774 Albiducin B Polyketide 2018 Preclinical
1775 NOSO-502 Odilorhabdin 2015 Preclinical
1776 SMT-738 LolCDE inhibitor 2020 Preclinical
1777 POL7306 Antimicrobial peptidomimetic (outer-membrane protein targeting antibiotic) 2018 Preclinical
1778 EBL-1463 Cell-wall synthesis inhibitor (dabocin) 2017 Preclinical
1779 2G-Dabocin Cell-wall synthesis inhibitor (dabocin) 2017 Preclinical
1780 OMN6 Antimicrobial peptide 2019 Phase 1
1781 LYT100 Lysin 2019 Preclinical
1782 Program 1 Aminoglycoside 2019 Preclinical
1783 TRL1068 Antibody (monoclonal antibody [mAb]) 2016 Phase 2 (NCT06621251)
1784 RESP-X Antibody (monoclonal antibody [mAb]) 2019 Phase 1
1785 MET-X Beta-lactamase inhibitor (metallo beta-lactamase inhibitor) 2022
1786 ALS-4 Antivirulence agent 2017 Phase 1
1787 PED-011 Antisense oligonucleotide 2019 Preclinical
1788 PED-012 Antisense oligonucleotide 2019 Preclinical
1789 PED-013 Antisense oligonucleotide 2019 Preclinical
1790 PED-019 Antisense oligonucleotide 2019 Preclinical
1791 PLG0206 Antimicrobial peptide 2021 Phase 2
1792 CMTX-101 Antibody (monoclonal antibody [mAb]) 2020 Phase 1/Phase 2 (NCT06159725)
1793 BV200 Antivirulence agent 2021 Preclinical
1794 RX-04 Pyrrolocytosine 2018 Preclinical
1795 Debio1454 Fatty acid synthesis inhibitor (FabI inhibitor) 2019 Preclinical
1796 Octapeptin Lipopeptide 2018 Preclinical
1797 LasB inhibitor LasB inhibitor (mercaptoacetamide) 2020 Preclinical
1798 α-hemolysin inhibitor Alpha-hemolysin inhibitor 2020 Preclinical
1799 Cystobactamid Bacterial topoisomerase inhibitor 2019 Preclinical
1800 Stapled Antimicrobial Peptides Antimicrobial peptide 2019 Preclinical
1801 DaaRS Aminoacyl-tRNA synthetase inhibitor 2019 Preclinical
1802 Pei Pseudomonas elastase inhibitor 2021 Preclinical
1803 Amurin Amurin 2019 Preclinical
1804 ASN-4 Antibody (monoclonal antibody [mAb]) 2018 Preclinical
1805 INBRX-111 Antibody (monoclonal antibody [mAb]) 2017 Preclinical
1806 MRL-494 BamA inhibitor 2019 Preclinical
1807 Actinocarbasin Lipoglycopeptide (arilomycin) 2012 Preclinical
1808 Krisynomycin Cyclic depsipeptide 2012 Preclinical
1809 G2824 Lgt inhibitor 2021 Preclinical
1810 Globomycin Lipopeptide 1978 Preclinical
1811 Myxovirescin Macrocyclic antibiotic 1982 Preclinical
1812 G0507 Pyrrolopyrimidinedione 2018 Preclinical
1813 Epetraborole Aminoacyl-tRNA synthetase inhibitor (boron-heterocyclic leucyl-tRNA synthetase [LeuRS] inhibitor) 2013 Phase 2
1814 Bicyclomycin Cyclic dipeptide (2,5-diketopiperazine) 1974
1815 CBR703 RNA polymerase inhibitor (hydroxamidine) 2003 Preclinical
1816 Roseoflavin FMN riboswitch binder 1974 Preclinical
1817 MAC13772 Biotin biosynthesis inhibitor 2013 Preclinical
1818 Darobactin BamA inhibitor (bicyclic heptapeptide antibiotic) 2019 Preclinical
1819 MUT350 Beta-lactamase inhibitor (diazabicyclooctane [DBO]) 2019 Preclinical
1820 ETX0462 Beta-lactamase inhibitor (diazabicyclooctane [DBO]) 2021 Preclinical
1821 ANT3310 Beta-lactamase inhibitor (diazabicyclooctane [DBO]) 2020 Preclinical
1822 ANT2681 Beta-lactamase inhibitor (thiazole metallo beta-lactamase inhibitor ) 2019 Preclinical
1823 MBX-4132 Uriedooxadiazole 2020 Preclinical
1824 Klebicin Antimicrobial peptide (Klebsiella colicin-like bacteriocin) 1987 Preclinical
1825 OPT-200 Lipopolysaccharide synthesis inhibitor 2017 Preclinical
1826 OPT-500 Isoprenoid inhibitor 2020 Preclinical
1827 OPT-600 Isoprenoid inhibitor 2020 Preclinical
1828 GSK3882347 FimH antagonist 2020 Phase 1
1829 CMTX-001 Antibody (monoclonal antibody [mAb]) 2020 Preclinical
1830 Corbomycin Glycopeptide 2020 Preclinical
1831 Complestatin Glycopeptide 1989 Preclinical
1832 DIS-73285 Electron transport chain inhibitor 2018 Preclinical
1833 Novobiocin Aminocoumarin 1955 Approved by FDA in 1964
1834 Chlorobiocin (NSC 227186 in NCI compound library) Aminocoumarin 1972
1835 Declovanillobiocin Aminocoumarin 2004
1836 Isovanillobiocin Aminocoumarin 2004
1837 Novclobiocin 101 Aminocoumarin 2003
1838 Vanillobiocin Aminocoumarin 2004
1839 Gentamicin Aminoglycoside 1962 Approved by FDA in 1970
1840 Kanamycin Aminoglycoside 1957 Approved by FDA in 1973
1841 Amikacin Aminoglycoside 1976 Approved by FDA in 1981
1842 Spectinomycin Aminoglycoside 1961 Approved by FDA in 1971
1843 Capreomycin Tuberactinomycin (cyclic peptide often grouped with aminoglycoside) 1960 Approved by FDA in 1971
1844 Tobramycin Aminoglycoside 1965 Approved by FDA in 1975
1845 Apramycin Aminoglycoside 1979 Phase 1 for human use (as of 2022)
1846 Arbekacin Aminoglycoside 1973 Phase 1 for inhalation (since 2013)
1847 Dibekacin Aminoglycoside 1975
1848 Netilmicin Aminoglycoside 1973 Approved by FDA in 1983
1849 Isepamicin Aminoglycoside 1973
1850 Neomycin Aminoglycoside 1947 Approved by FDA in 1964
1851 Sisomicin Aminoglycoside 1950 Phase 4 (NCT00202891)
1852 Paromomycin Aminoglycoside 1960 Approved by FDA in 1969
1853 Ribostamycin Aminoglycoside 1970
1854 Micronomicin Aminoglycoside 1983
1855 Dihydrostreptomycin Aminoglycoside 1949
1856 Bekanamycin Aminoglycoside 1969
1857 Rifabutin Rifamycin 1975 Approved by FDA in 1992
1858 Rifapentine Rifamycin 1965 Approved by FDA in 1998
1859 Rifaximin Rifamycin 1980 Approved by FDA in 2004
1860 Rifamycin Rifamycin 1957 Approved by FDA in 2018
1861 Imipenem Beta-lactam (carbapenem) 1977 Approved by FDA in 2019
1862 Meropenem Beta-lactam (carbapenem) 1983 Approved by FDA in 1996
1863 Biapenem Beta-lactam (carbapenem) 1995 Phase 1 (NCT01772836)
1864 Doripenem Beta-lactam (carbapenem) 2003 Approved by FDA in 2007
1865 Ertapenem Beta-lactam (carbapenem) 1992 Approved by FDA in 2001
1866 Olivanic acid Drug combination: beta-lactam (carbapenem) + beta-lactamase inhibitor 1974
1867 Panipenem Beta-lactam (carbapenem) 1982 Approved (not in US)
1868 Benapenem Beta-lactam (carbapenem) 2015 Phase 3 (NCT04505683)
1869 Sulopenem Beta-lactam (penem) 1989 Approved by FDA in 2024
1870 Clavulanic acid Beta-lactamase inhibitor (clavam, bicyclic beta-lactam without a penicillin or cephalosporin nucleus) 1976
1871 Sulbactam Beta-lactamase inhibitor (penicillanic acid sulfone) 1978 Approved by FDA in 1986
1872 Tazobactam Beta-lactamase inhibitor (penicillanic acid sulfone) 1982 Approved by FDA in 1993
1873 Enmetazobactam Beta-lactamase inhibitor (penicillanic acid sulfone) 1998 Approved by FDA in 2024
1874 Avibactam (Avycaz, Zavicefta) Beta-lactamase inhibitor (non-beta-lactam beta-lactamase inhibitor, diazabicyclooctane [DBO]) 2002 Approved by FDA in 2015
1875 Relebactam Beta-lactamase inhibitor (non-beta-lactam beta-lactamase inhibitor, diazabicyclooctane [DBO]) 2009 Approved by FDA in 2019
1876 Vaborbactam Beta-lactamase inhibitor (heterocyclic boron) 2013 Approved by FDA in 2017
1877 Cefadroxil Beta-lactam (cephalosporin, first generation) 1967 Approved by FDA in 1987
1878 Cefazolin Beta-lactam (cephalosporin, first generation) 1967 Approved by FDA in 1987
1879 Cephalexin Beta-lactam (cephalosporin, first generation) 1967 Approved by FDA in 1978
1880 Cephaloridine Beta-lactam (cephalosporin, first generation) 1962 Approved
1881 Cephalotin Beta-lactam (cephalosporin, first generation) 1962 Approved
1882 Cephapirin Beta-lactam (cephalosporin, first generation) 1971 Approved by FDA in 1974
1883 Cephradine Beta-lactam (cephalosporin, first generation) 1972 Approved by FDA in 1974
1885 Cephaloglycin Beta-lactam (cephalosporin, first generation) 1965 Approved by FDA in 1970
1886 Cefazedone Beta-lactam (cephalosporin, first generation) 1979
1887 Cefatrizine Beta-lactam (cephalosporin, first generation) 1974
1888 Ceftezole Beta-lactam (cephalosporin, first generation) 1976
1889 Cefaclor Beta-lactam (cephalosporin, second generation) 1973 Approved by FDA in 1979
1890 Cefamandole Beta-lactam (cephalosporin, second generation) 1974
1891 Cefmetazole Beta-lactam (cephalosporin, second generation) 1979 Approved by FDA in 1989
1892 Cefonicid Beta-lactam (cephalosporin, second generation) 1981 Approved by FDA in 1984
1893 Ceforanide Beta-lactam (cephalosporin, second generation) 1979 Approved by FDA in 1984
1894 Cefotetan Beta-lactam (cephalosporin, second generation) 1981
1895 Cefoxitin Beta-lactam (cephalosporin, second generation) 1972
1896 Cefprozil Beta-lactam (cephalosporin, second generation) 1983
1897 Cefuroxime Beta-lactam (cephalosporin, second generation) 1971
1898 Loracarbef Beta-lactam (cephalosporin, second generation) 1991 Approved by FDA in 1991
1899 Flomoxef Beta-lactam (cephalosporin, second generation) 1980
1900 Cefbuperazone Beta-lactam (cephalosporin, second generation) 1982
1901 Cefotiam Beta-lactam (cephalosporin, second generation) 1979 Approved by FDA in 1988
1902 Cefminox Beta-lactam (cephalosporin, second generation) 1983
1903 Ceftazidime Beta-lactam (cephalosporin, third generation) 1978
1904 Cefdinir Beta-lactam (cephalosporin, third generation) 1979
1905 Cefditoren Beta-lactam (cephalosporin, third generation) 1984
1906 Cefetamet Beta-lactam (cephalosporin, third generation) 1985
1907 Cefixime Beta-lactam (cephalosporin, third generation) 1984
1908 Cefmenoxime Beta-lactam (cephalosporin, third generation) 1980 Approved by FDA in 1987
1909 Cefoperazone Beta-lactam (cephalosporin, third generation) 1974 Approved by FDA in 1982
1910 Cefotaxime Beta-lactam (cephalosporin, third generation) 1979
1911 Cefpiramide Beta-lactam (cephalosporin, third generation) 1982 Approved by FDA in 1989
1912 Cefpodoxime Beta-lactam (cephalosporin, third generation) 1980 Approved by FDA in 1992
1913 Ceftibuten Beta-lactam (cephalosporin, third generation) 1987 Approved by FDA in 1995
1914 Ceftriaxone Beta-lactam (cephalosporin, third generation) 1980 Approved by FDA in 1984
1915 Latamoxef Beta-lactam (cephalosporin, third generation) 1982 Approved
1916 Cefcapene Beta-lactam (cephalosporin, third generation) 1997 Approved in Japan
1917 Cefodizime Beta-lactam (cephalosporin, third generation) 1978
1919 Cefepime Beta-lactam (cephalosporin, fourth generation) 1982 Approved by FDA in 1996
1920 Cefoselis Beta-lactam (cephalosporin, fourth generation) 1993 Approved in Japan
1921 Cefozopran Beta-lactam (cephalosporin, fourth generation) 1991 Approved in Japan
1922 Penicillin V Beta-lactam (penicillin) 1948 Approved by FDA
1923 Penicillin G Beta-lactam (penicillin) 1938 Approved by FDA in 1951
1924 Amoxicillin Beta-lactam (aminopenicillin) 1958 Approved by FDA in 1974
1925 Ampicillin Beta-lactam (aminopenicillin) 1953 Approved by FDA in 1971
1926 Azlocillin Beta-lactam (ureidopenicillin) 1975 Approved
1927 Carbenicillin Beta-lactam (carboxypenicillin) 1967 Approved by FDA
1928 Cloxacillin Beta-lactam (isoxazolylpenicillin) 1963 Approved by FDA in 1971
1929 Dicloxacillin Beta-lactam (isoxazolylpenicillin) 1964
1930 Epicillin Beta-lactam (aminopenicillin) 1971
1931 Flucloxacillin Beta-lactam (isoxazolylpenicillin) 1970 Approved
1932 Hetacillin Beta-lactam (aminopenicillin) 1965 Approved by FDA in 1971
1933 Methicillin Beta-lactam (penicillin) 1960 Approved by FDA in 1971
1934 Mezlocillin Beta-lactam (ureidopenicillin) 1976 Approved by FDA in 1981
1935 Nafcillin Beta-lactam (penicillin, naphthalen) 1961 Approved by FDA in 1970
1936 Oxacillin Beta-lactam (isoxazolylpenicillin) 1960 Approved by FDA in 1989
1937 Piperacillin Beta-lactam (ureidopenicillin) 1974 Approved by FDA in 1981
1938 Sulbenicillin Beta-lactam (penicillin with increased spectrum) 1970 Approved
1939 Ticarcillin Beta-lactam (carboxypenicillin) 1963 Approved by FDA in 1976
1940 Metampicillin Beta-lactam (aminopenicillin) 1969 Approved
1941 Penamecillin Beta-lactam (penicillin) 1966 Approved
1943 Pheneticillin Beta-lactam (penicillin) 1961 Approved for veterinary use in EU
1944 Carindacillin Beta-lactam (carboxypenicillin) 1972 Approved by FDA in 1972
1945 Carfecillin Beta-lactam (carboxypenicillin) 1974
1946 Cyclacillin Beta-lactam (aminopenicillin) 1970 Approved by FDA in 1979
1947 Talampicillin Beta-lactam (aminopenicillin) 1974
1948 Sultamicillin Beta-lactam (Aminopenicillin) 1982 Approved by FDA in 1986
1949 Azidocillin Beta-lactam (aminopenicillin) 1968
1950 Propicillin Beta-lactam (penicillin) 1961
1951 Bacampicillin Beta-lactam (aminopenicillin) 1975 Approved by FDA in 1980
1952 Aspoxicillin Beta-lactam (penicillin) 1983 Approved in Japan
1953 Clometocillin Beta-lactam (penicillin) 1964
1954 Sulbactam plus durlobactam (Xacduro) Beta-lactamase inhibitor (penicillanic acid sulfone) 2017 Approved by FDA in 2023
1955 Nacubactam Beta-lactamase inhibitor (non-beta-lactam beta-lactamase inhibitor, diazabicyclooctane [DBO]) 2015 Phase 3 (NCT05905055)
1956 Imipenem/funobactam Beta-lactamase inhibitor (non-beta-lactam beta-lactamase inhibitor, diazabicyclooctane [DBO]) 2021 Phase 3
1957 Ledaborbactam Beta-lactamase inhibitor (boron-based) 2017 Phase 1 (as of 2022)
1958 Durlobactam Beta-lactamase inhibitor (non-beta-lactam beta-lactamase inhibitor, diazabicyclooctane [DBO]) 2017 Phase 3 (NCT03894046)
1959 ETX-0282 Beta-lactamase inhibitor (non-beta-lactam beta-lactamase inhibitor, diazabicyclooctane [DBO]) 2019 Phase 1 (as of 2022)
1960 Aztreonam Beta-lactam (monobactam) 1979
1961 Nocardicin A Beta-lactam (monobactam) 1975
1962 Carumonam Beta-lactam (monobactam) 1984
1963 Gloximonam Beta-lactam (monobactam, oxymazins) 1985
1964 Oximonam Beta-lactam (monobactam, oxymazins) 1985
1965 Trimethoprim Diaminopyrimidine 1962
1966 Iclaprim Diaminopyrimidine 2003
1967 Brodimoprim Diaminopyrimidine 1984
1968 Epiroprim Diaminopyrimidine 1993
1969 Tetroxoprim Diaminopyrimidine 1979
1970 Helvolic acid Fusidane 1943
1971 Cephalosporin P1 Fusidane 1951
1972 Telavancin Lipoglycopeptide 2002
1973 Lincomycin Lincosamide 1958
1974 Clindamycin Lincosamide 1964
1975 Daptomycin (Cubicin) Lipopeptide 1986
1976 Tinidazole Nitroimidazole 1969
1977 Pretomanid (Dovprela) Nitroimidazole 2000 Approved by FDA in 2019
1978 Nitrofurantoin Nitrofuran 1952
1979 Furazolidone Nitrofuran 1953
1980 Nifurquinazol Nitrofuran
1981 Nifurtoinol Nitrofuran 1973
1982 Nifuratel Nitrofuran 1960
1983 Nifuroxazide Nitrofuran 1966
1984 Nifurtimox Nitrofuran 1965
1985 Nifurzide Nitrofuran 1981
1986 Nitrofurazone Nitrofuran 1946
1987 Furagin Nitrofuran 1984
1988 Azidamfenicol Phenicol 1978
1989 Chloramphenicol Phenicol 1947
1990 Florfenicol Phenicol 1981
1991 Tevenel Phenicol 1975
1992 Thiamphenicol Phenicol 1959
1993 Pleuromutilin Pleuromutilin 1951
1994 Retapamulin Pleuromutilin 2005
1995 Erythromycin Macrolide (14-membered macrolide) 1952
1996 Telithromycin Macrolide (14-membered macrolide, ketolide) 1994
1997 Modithromycin Macrolide (14-membered macrolide, ketolide) 1981 Phase 1
1998 Roxithromycin Macrolide (14-membered macrolide) 1986
1999 Spiramycin Macrolide (16-membered macrolide) 1954
2000 Midecamycin Macrolide (16-membered macrolide) 1975
2001 Rokitamycin Macrolide (16-membered macrolide) 1981
2002 Flurithromycin Macrolide (14-membered macrolide) 1985
2003 Dirithromycin Macrolide (14-membered macrolide) 1987 Approved by FDA in 1995
2004 Oleandomycin Macrolide (14-membered macrolide) 1945
2005 Troleandomycin Macrolide (14-membered macrolide) 1964
2006 Josamycin Macrolide (16-membered macrolide) 1964
2007 Fidaxomicin Macrolide (18-membered macrolide, tiacumicin) 1980
2008 Tetracycline Tetracycline 1953
2009 Chlortetracycline Tetracycline 1945
2010 Oxytetracycline (terramycin) Tetracycline 1952
2011 Doxycycline Tetracycline 1957
2012 Tigecycline Tetracycline 1999
2013 Demeclocycline Tetracycline 1962
2014 Meclocycline Tetracycline 1964
2015 Rolitetracycline Tetracycline 1958
2016 Lymecycline Tetracycline 1961
2017 Clomocycline Tetracycline 1966
2018 Bacitracin Polypeptide 1943
2019 Colistin Polymyxin 1947
2020 Polymyxin B Polymyxin 1947
2021 Tyrothricin Polypeptide 1940
2022 Gramicidin Polypeptide 1939
2023 Nalidixic acid Quinolone 1962
2024 Ciprofloxacin Fluoroquinolone 1980
2025 Moxifloxacin Fluoroquinolone 1989 Approved by FDA in 2001
2026 Levofloxacin Fluoroquinolone 1985
2027 Sitafloxacin Fluoroquinolone 1992
2028 Cinoxacin Quinolone 1972 Approved by FDA in 1980
2029 Prulifloxacin Fluoroquinolone 1987
2030 Enoxacin Fluoroquinolone 1983 Approved by FDA in 1991
2031 Garenoxacin Fluoroquinolone 2000
2032 Gemifloxacin Fluoroquinolone 1997
2033 Lomefloxacin Fluoroquinolone 1987 Approved by FDA in 1992
2034 Nadifloxacin Fluoroquinolone 1989
2035 Pipemidic acid Quinolone 1974
2036 Norfloxacin Fluoroquinolone 1978
2037 Ofloxacin Fluoroquinolone 1980
2038 Pazufloxacin Fluoroquinolone 1986
2039 Pefloxacin Fluoroquinolone 1979
2040 Rufloxacin Fluoroquinolone 1987 Approved
2041 Sparfloxacin Fluoroquinolone 1985 Approved by FDA in 1996
2042 Temafloxacin Fluoroquinolone 1984 Approved by FDA in 1992
2043 Trovafloxacin Fluoroquinolone 1993 Approved by FDA in 1997
2045 Piromidic acid Quinolone 1967
2046 Fleroxacin Fluoroquinolone 1986
2048 Finafloxacin Fluoroquinolone 2000
2049 Tosufloxacin Fluoroquinolone 1985
2050 Besifloxacin Fluoroquinolone 2000
2051 Levonadifloxacin Fluoroquinolone 2001 Approved 2014
2052 Flumequine Fluoroquinolone 1973
2053 Pristinamycin Streptogramin 1962
2054 Quinupristin/dalfopristin (Synercid) Streptogramin 1989 Approved by FDA in 1999
2055 Dalfopristin Streptogramin 1989
2056 Quinupristin Streptogramin 1989 Approved
2057 Prontosil Sulfa drug / Sulphonamide 1935
2058 Sulfanilamide Sulfa drug / Sulphonamide 1940
2059 Sulfabenzamide Sulfa drug / Sulphonamide 1943
2060 Sulfacetamide Sulfa drug / Sulphonamide 1941
2061 Sulfachlorpyridazine Sulfa drug / Sulphonamide 1957
2062 Sulfadiazine Sulfa drug / Sulphonamide 1941
2063 Sulfadimethoxine Sulfa drug / Sulphonamide 1958
2064 Sulfaguanidine Sulfa drug / Sulphonamide 1941
2065 Sulfamerazine Sulfa drug / Sulphonamide 1944
2067 Sulfamethazine Sulfa drug / Sulphonamide 1945
2068 Sulfamethizole Sulfa drug / Sulphonamide 1953
2069 Sulfamethoxazole Sulfa drug / Sulphonamide 1950
2070 Sulfamethoxypyridazine Sulfa drug / Sulphonamide 1956
2071 Sulfamonomethoxine Sulfa drug / Sulphonamide 1962
2072 Sulfaphenazole Sulfa drug / Sulphonamide 1958
2073 Sulfapyridine Sulfa drug / Sulphonamide 1937
2074 Sulfathiazole Sulfa drug / Sulphonamide 1942
2075 Sulfisoxazole Sulfa drug / Sulphonamide 1949
2076 Sulfametomidine Sulfa drug / Sulphonamide 1961
2077 Sulfamethoxypyrazine Sulfa drug / Sulphonamide 1953
2078 Sulfadoxine Sulfa drug / Sulphonamide 1962
2079 Sulfametrole Sulfa drug / Sulphonamide 1975
2080 Sulfaperine Sulfa drug / Sulphonamide 1946
2081 Sulfamoxole Sulfa drug / Sulphonamide 1961
2082 Sulfasalazine Sulfa drug / Sulphonamide 1959
2083 Sulfathiourea Sulfa drug / Sulphonamide 1946
2084 Mafenide Sulfa drug / Sulphonamide 1948
2085 Sulfamethoxazole+trimethoprim Drug combination 1959
2086 Thiolutin RNA polymerase inhibitor (dithiolopyrrolone) 1950
2087 Holomycin RNA polymerase inhibitor (dithiolopyrrolone) 1959
2088 Aureothricin RNA polymerase inhibitor (dithiolopyrrolone) 1948
2089 Actinorhodin Polyketide 1947
2090 Batumin Fatty acid synthesis inhibitor (FabI inhibitor, polyketide) 1996
2091 Ripostatin RNA polymerase inhibitor 1995
2092 Murgocil MurG inhibitor 2013
2093 Friulimicin Lipopeptide 2000 Phase 1
2094 Copsin Antimicrobial peptide (defensin) 2014
2095 Fosfonochlorin Phosphonic acid 1982
2096 Tiamulin Pleuromutilin 1951
2097 Valnemulin Pleuromutilin 1997
2098 Cycloserine Isoxazoline 1955 Approved by FDA in 1964
2099 Streptolydigin RNA polymerase inhibitor 1955
2100 Streptomycin Aminoglycoside 1944 Approved by FDA in 1946
2101 Ceftetrame (Ro15-8074) Beta-lactam 1984 Preclinical
2102 Tunicamycin Natural product antibiotic 1971
2103 Amphomycin Lipopeptide 1953
2104 MX-2401 Small molecule antibacterial agent 2006 Preclinical
2105 Muraymycin Natural product antibiotic 2002
2106 Liposidomycin Natural product antibiotic 1985
2107 Capuramycin Natural product antibiotic 1986
2108 Muraminomicin Natural product antibiotic 2012
2109 CPZEN-45 Small molecule antibacterial agent 2008 Preclinical
2110 Pacidamycin Natural product antibiotic 1988
2111 Sansanmycin Natural product antibiotic 2007
2113 Malioxamycin Natural product antibiotic 1980
2114 Luminamicin Macrolide 1985
2115 Thiotetromycin Natural product antibiotic 1983
2116 Thiolactomycin Natural product antibiotic 1981
2117 Thiotetroamide Natural product antibiotic 1988
2118 Fumaramidimycin Natural product antibiotic 1975
2119 Nodusmicin Macrolide 1980
2120 Nargenicin Macrolide 1980
2121 IMB-H4 Small molecule antibacterial agent 2020
2122 Swalpamycin Macrolide 1987
2123 Gargantulide A, B, C Macrolide 2015
2124 Monazomycin Natural product antibiotic 1963
2125 Desertomycin A, B, G, H Natural product antibiotic 1958
2126 Moiramide A, B, C Natural product antibiotic 1994
2127 Corytuberine Natural product antibiotic 2006
2128 CG 3401 Small molecule antibacterial agent 1975
2129 IMB-0042 Small molecule antibacterial agent 2022
2130 Relacidine and analogues Lipopeptide 2018
2131 Brevicidine Lipopeptide 2018
2132 Laterocidine Lipopeptide 2018
2133 Paenibacterin and analogues Lipopeptide 2012
2134 Bogorol and analogues Lipopeptide 2001
2135 Brevibacillin and analogues Lipopeptide 2016
2136 Succilin and analogues Lipopeptide 2020
2137 Cerexin and analogues Lipopeptide 1975
2138 Laterosporulin and analogues Lipopeptide 2012
2139 GSK945237 Small molecule antibacterial agent 2016 Phase 1
2140 AM-8722 Small molecule antibacterial agent 2014 Phase 1
2141 AM-8085 Small molecule antibacterial agent 2014
2142 DS-2969b Small molecule antibacterial agent 2017 Phase 1
2143 JSF-2414 Small molecule antibacterial agent 2022
2144 Fascaplysin and derivatives Natural product antibiotic 1988
2145 DS01750413 Small molecule antibacterial agent 2021
2146 GE23077 Natural product antibiotic 2004
2147 Macolacin and analogues Polymyxin 2022
2148 Heteroaryl isothiazolones Small molecule antibacterial agent 2006
2149 Streptavidin Antimicrobial peptide 1964
2150 Amiclenomycin Antimicrobial peptide 1974
2152 Tomaymycin Natural product antibiotic 1972
2153 Fumaquinone Natural product antibiotic 2005
2154 CMB001 Antimicrobial peptide 2020
2155 Pa-MAP 2 Antimicrobial peptide 2012
2156 SLAP-S25 Antimicrobial peptide 2020
2157 Paeoniflorin Drug efflux pump inhibitor 2020
2158 Compound 137 Small molecule antibacterial agent 2022
2159 SC5005 Small molecule antibacterial agent 2015
2160 PLP-3 Antimicrobial peptide 2022
2161 S-MGB-364 Small molecule antibacterial agent 2017
2162 Econazole Small molecule antibacterial agent 2021
2163 CF-296 Bacteriophage and/or bacteriophage-derived product 2021 Preclinical
2164 WAM-1 Antimicrobial peptide 2018
2165 Pyocin S5 and pyocin AP41 Antimicrobial peptide 2021
2166 PIM1 Antimicrobial peptide 2020
2167 BTZ-043 Small molecule antibacterial agent 2009 Phase 2 (NCT04044001)
2168 GSK2556286 Small molecule antibacterial agent 2022 Phase 1 (NCT04472897)
2169 T405 Beta-lactam 2020
2170 Kanglemycin A Rifamycin 2018
2171 EC/11716 DNA synthesis inhibitor 2021
2172 Punicalagin Antivirulence agent 2022
2173 MRX-6038 Small molecule antibacterial agent 2022
2174 CDBN-YGXZ Small molecule antibacterial agent 2023
2175 Negamycin Antimicrobial peptide 1970
2176 Hinokiflavone Antivirulence agent 2014
2177 AN11527 Small molecule antibacterial agent 2017
2178 Telacebec Small molecule antibacterial agent 2013 Phase 2 (NCT06481163)
2179 TBAJ-587 Small molecule antibacterial agent 2019 Phase 1 (NCT04890535)
2180 PBT2 Small molecule antibacterial agent 2005
2181 S02030 and MB_076 Beta-lactamase inhibitor 2016
2182 TBI-166 Small molecule antibacterial agent 2012 Phase 2 (NCT04670120)
2183 TPP8 Small molecule antibacterial agent 2022
2184 EC/11770 Small molecule antibacterial agent 2015
2185 CUO246 Small molecule antibacterial agent 2022
2186 TBI-223 Oxazolidinone 2019 Phase 1 (NCT04865536)
2187 Febuxostat Small molecule antibacterial agent 2022
2188 Cyclohexyl-griselimycin Antimicrobial peptide 2015
2189 GaMF1 Small molecule antibacterial agent 2020
2190 TPN-0006239 Small molecule antibacterial agent 2017
2191 Vancapticin Lipoglycopeptide 2023
2192 Gp105 Bacteriophage and/or bacteriophage-derived product 2022
2193 Sulfoxanthicillin Natural product antibiotic 2023
2194 Chrysomycin A Natural product antibiotic 1955
2195 PE-2C-C8-DH Polymyxin 2023
2196 IMB-XMA0038 Small molecule antibacterial agent 2021
2197 Tumebacin Natural product antibiotic 2023
2198 Mollicellin S Natural product antibiotic 2021
2199 Avidumicin Antimicrobial peptide 2023
2200 TP0586532 Small molecule antibacterial agent 2021
2201 Pulvomycin Aminoglycoside 1957
2202 GT-1 Beta-lactam 2017 Phase 1 (Australia ACTRN12618001980224)
2203 GT-055 Beta-lactamase inhibitor 2020
2204 ZIF-67 Small molecule antibacterial agent 2021
2205 Pestalotinone A, pestalotinone B, and pestalotinone  C Natural product antibiotic 2022
2206 Kimidinomycin Macrolide 2022
2207 Rausuquinone Natural product antibiotic 2022
2208 Wychimicin Natural product antibiotic 2022
2209 Thiosemicarbazone Beta-lactamase inhibitor 2020
2210 TXA6101 Small molecule antibacterial agent 2022
2211 GA003 Natural product antibiotic 2021
2212 Suertide Antimicrobial peptide 2022
2213 2-(2-amino-3-chloro-benzoylamino)-benzoic acid Antivirulence agent 2022
2214 Mycomethoxin B Natural product antibiotic 1972
2215 CSA-13 Antimicrobial peptide 2005
2216 Longicatenamide Antimicrobial peptide 2021
2217 Aldsulfin Natural product antibiotic 2021
2218 Tetrahydropiperic acid Antimicrobial peptide 2021
2219 H2-60, H2-81 Small molecule antibacterial agent 2021
2220 C20-epi-salinomycin derivative Small molecule antibacterial agent 2022
2221 5-O-mycaminosyltylonolide Macrolide 2006
2222 Iboxamycin Small molecule antibacterial agent 2021
2223 Abaucin Small molecule antibacterial agent 2023
2224 Thermorubin Natural product antibiotic 1964
2225 GP6738 Glycopeptide 2020
2226 Dynobactin Antimicrobial peptide 2022
2227 Rifaphenzine Rifampicin 2021
2228 3′,4′-difluoroquercetin Small molecule antibacterial agent 2012
2229 BDM73185 Drug efflux pump inhibitor 2022
2230 Picolinamycin Natural product antibiotic 2020
2231 PIS-A-1 Antimicrobial peptide 2022
2232 Tatiomicin Natural product antibiotic 2022
2233 Menaquinone Binding Antibiotic (MBA) Small molecule antibacterial agent 2022
2234 Lawsone derivative 6c Small molecule antibacterial agent 2020
2235 Venturicidin A Natural product antibiotic 1989
2236 Evybactin Antimicrobial peptide 2022
2237 Mithramycin A Natural product antibiotic 2004
2238 Pyrimidomycin Natural product antibiotic 2022
2239 F365 Lipopeptide 2022 Phase 1 (NCT04808414)
2240 Plantaricin NC8 β derivative Lipopeptide 2023
2241 6-thioguanine Natural product antibiotic 2021
2242 MAD1 Antimicrobial peptide 2021
2243 g-D50 Membrane-active agent 2023
2244 PA-13 Antimicrobial peptide 2020
2245 BING Antimicrobial peptide 2021
2246 Ticagrelor Nucleoside analogue 2019
2247 D-AP19 Antimicrobial peptide 2022
2248 Homicorcin Antimicrobial peptide 2021
2249 Angicin Antimicrobial peptide 2021
2250 NAT13-338148 Small molecule antibacterial agent 2021
2251 Sphaerimicin analogue Small molecule antibacterial agent 2022
2252 Myricetin Small molecule antibacterial agent 2023
2253 Ruminococcin C1 Antimicrobial peptide 2019
2254 Oxadiazole 1 Small molecule antibacterial agent 2023
2255 DSM186 Small molecule antibacterial agent 2022
2256 PS757 Small molecule antibacterial agent 2022
2257 Compound 10 HD5 analogue Antimicrobial peptide 2022
2258 Kasugamycin Aminoglycoside 1965
2259 1-amino substituted tetrahydrocarbazole (THCz) Cell wall synthesis inhibitor 2021
2260 AB569 Small molecule antibacterial agent 2020
2261 Amycomicin Natural product antibiotic 2018
2262 L-CS319 Beta-lactamase inhibitor 2015
2263 Clomiphene Cell wall synthesis inhibitor 2015
2264 Auranofin Small molecule antibacterial agent 2015
2265 Micasin Antimicrobial peptide 2012
2266 Bithionol Membrane-active agent 2019
2267 Tridecaptin A1 Lipopeptide 2016
2268 4,6-diaryl-5,7-dimethyl coumarin Small molecule antibacterial agent 2013
2269 Planosporicin Antimicrobial peptide 2007
2270 Geobacillin I Antimicrobial peptide 2012
2271 Geobacillin II Antimicrobial peptide 2012
2272 Thuricin CD Antimicrobial peptide 2010
2273 Hybrimycin A Aminoglycoside 1969
2274 Hybrimycin B Aminoglycoside 1969
2275 ZY4 Antimicrobial peptide 2019
2276 Arylfluorosulfate derivative compound 3 (Ar-O-SO2-F) Small molecule antibacterial agent 2021
2277 Arylfluorosulfate derivative compound 81 (Ar-O-SO2-F) Small molecule antibacterial agent 2021
2278 Arylfluorosulfate derivative compound 101 (Ar-O-SO2-F) Small molecule antibacterial agent 2021
2279 Horine Antimicrobial peptide 2020
2280 Verine Antimicrobial peptide 2020
2281 Peptide K6 Antimicrobial peptide 2023
2282 Shapeshifting vancomycin dimer (SVD 6d) Glycopeptide 2023
2283 Mitoxantrone Small molecule antibacterial agent 2023
2284 Omega 76 Antimicrobial peptide 2019
2285 Cutimycin Antimicrobial peptide (thiopeptide) 2020
2286 Small Molecule Aborting Resistance (SMARt-420) Small molecule antibacterial agent 2017
2287 DCH Antibiofilm agent 2020
2288 N-benzyl–substituted 3′-(R)-3′-aminomethyl-3′-hydroxy spectinomycin 1 Aminoglycoside 2015
2289 N-benzyl–substituted 3′-(R)-3′-aminomethyl-3′-hydroxy spectinomycin 2 Aminoglycoside 2015
2290 N-benzyl–substituted 3′-(R)-3′-aminomethyl-3′-hydroxy spectinomycin 3 Aminoglycoside 2015
2291 N-benzyl–substituted 3′-(R)-3′-aminomethyl-3′-hydroxy spectinomycin 4 Aminoglycoside 2015
2292 Cilagicin Lipopeptide 2022
2293 Cilagicin BP Lipopeptide 2022
2294 Mast-MO Antimicrobial peptide 2020
2295 3,5- dimethoxy-2-(methylthio)cyclohexa-2,5-diene-1,4-dione Small molecule antibacterial agent 2019
2296 5-methoxy-2,3- bis(methylthio)cyclohexa-2,5-diene-1,4-dione Small molecule antibacterial agent 2019
2297 Cholestenone Small molecule antibacterial agent 2021
2298 AZ1 Small molecule antibacterial agent 2015
2299 JH-LPH-28 Small molecule antibacterial agent 2020
2300 JH-LPH-33 Small molecule antibacterial agent 2020
2301 NL1 Small molecule antibacterial agent 2021
2302 NL2 Small molecule antibacterial agent 2021
2303 NL3 Small molecule antibacterial agent 2021
2304 Oligoamidine 3 Membrane-active agent 2021
2305 SAAP-148 Antimicrobial peptide 2018
2306 LPC-233 Lipopolysaccharide synthesis inhibitor 2023
2307 Phenelfamycin B Natural product antibiotic 1988
2308 Equisetin Natural product antibiotic 2013
2309 Demethoxytetronasin Natural product antibiotic 2023
2310 Tetronasin Natural product antibiotic 1988
2311 Van-QC14 Glycopeptide 2016
2312 BAY 11-7082 Small molecule antibacterial agent 2022
2313 Feleucin-K59 (K59) Antimicrobial peptide 2021
2314 Plantazolicin Antimicrobial peptide 2011
2315 Phocoenamicin Macrolide 2018
2316 AMINOPIP2-ceftazidime 12 Beta-lactam 2020
2317 Ionized NonClassical Antifolate (INCA) compound 14 Small molecule antibacterial agent 2019
2318 TBL-140 Small molecule antibacterial agent 2016
2319 ETX1317 Beta-lactamase inhibitor 2020
2320 1,2,3-Triazolylmethaneboronate compound 6q Beta-lactamase inhibitor 2020
2321 MAC-0547630 Small molecule antibacterial agent 2016
2322 QDP-1 Beta-lactamase inhibitor 2022
2323 Pt@ZIF8 Membrane-active agent 2023
2324 Peptide 73 Antimicrobial peptide 2019
2325 Clovibactin Natural product antibiotic 2023
2326 SCH-79797 Membrane-active agent 2018
2327 Irresistin-16 Small molecule antibacterial agent 2020
2328 TAM16 Small molecule antibacterial agent 2017
2329 Pseudouridimycin Natural product antibiotic 2017
2330 Bacillimidazole G Natural product antibiotic 2023
2331 Artocarpin Membrane-active agent 2017
2332 Micrococcin P2 Antimicrobial peptide 2022
2333 Mindapyrrole B Natural product antibiotic 2019
2334 Berberine Drug efflux pump inhibitor 2010
2335 Krisynomycin B Antimicrobial peptide 2020
2336 Krisynomycin C Antimicrobial peptide 2020
2337 8-deacetylcyclocalopin B Natural product antibiotic 2018
2338 Somuncurin-1 Antimicrobial peptide 2020
2339 Arsinothricin Natural product antibiotic 2018
2340 Chuangxinmycin Natural product antibiotic 1976
2341 Enduracyclinone A Natural product antibiotic 2019
2342 Fucomycin V Natural product antibiotic 2023
2343 Tamarixetin Natural product antibiotic 2018
2344 Acidonemycin Antivirulence agent 2023
2345 Cudraflavone C Natural product antibiotic 2021
2346 Triculamin Antimicrobial peptide 1958
2347 Metamarin Antivirulence agent 2021
2348 Albomycin δ2 Natural product antibiotic 1947
2349 Salvarsan Small molecule antibacterial agent 1907
2350 Aspergillomarasmine A Beta-lactamase inhibitor 2021
2351 Beta-chloro-D-alanine Small molecule antibacterial agent 1974
2352 Cadaside A Lipopeptide 2019
2353 Cerulenin Natural product antibiotic 1960
2354 Thiomarinol A Natural product antibiotic 1993
2355 Ribocil C-PA Small molecule antibacterial agent 2020
2356 Vancomycin GR-MoTr conjugate Glycopeptide 2018
2357 Myxovalargin Antimicrobial peptide 1983
2358 Everninomicin P Natural product antibiotic 2020
2359 GE81112 B1 Antimicrobial peptide 2021
2360 Apralog 57β Aminoglycoside 2020
2361 Concolactam Antivirulence agent 2023
2362 Albofungin Natural product antibiotic 1973
2363 TAN1532B Natural product antibiotic 2018
2364 Bequinostatin E Natural product antibiotic 2018
2365 Benastatin B Natural product antibiotic 1992
2366 qDP-1 Small molecule antibacterial agent 2022
2367 Promysalin Natural product antibiotic 2011
2368 Streptosactin Antimicrobial peptide 2020
2369 AM10SL018 Polymyxin 2023
2370 L-linker daptomycin conjugate 7 Small molecule antibacterial agent 2020
2371 Mannopeptimycin Glycopeptide 1970
2372 Maxamycin 20 Glycopeptide 2023
2373 Maxamycin 21 Glycopeptide 2023
2374 Maxamycin 22 Glycopeptide 2023
2375 Dialkylamine 1 Natural product antibiotic 2021
2376 Chrysophaentin A Natural product antibiotic 2010
2377 Beta-peptide polymer P4 Antimicrobial peptide 2022
2378 Isopedopeptin B Antimicrobial peptide 2020
2379 V30-SP-8 Antimicrobial peptide 2020
2380 Liproxstatin-1 Small molecule antibacterial agent 2021
2381 MAC-0568743 Small molecule antibacterial agent 2021
2382 Harundomycin A Natural product antibiotic 2022
2383 Siamycin I Antimicrobial peptide 2017
2384 Oxa 1 Small molecule antibacterial agent 2020
2385 Oxa 2 Small molecule antibacterial agent 2020
2386 Obafluorin Natural product antibiotic 2019
2387 TXH9179 Small molecule antibacterial agent 2023
2388 GW3965 HCl Small molecule antibacterial agent 2019
2389 Cyclic temporin L peptide 12 Antimicrobial peptide 2021
2390 5-amino-4-quinolone 111 Quinolone 2022
2391 Neolignan-AMP mimic conjugate III5 Antimicrobial peptide 2022
2392 Neolignan-AMP mimic conjugate III15 Antimicrobial peptide 2022
2393 Apidaecin 137 Antimicrobial peptide 2013
2394 Anoplin A-21 Antimicrobial peptide 2021
2395 6-arylmethylidene penicillin-based sulfone Beta-lactamase inhibitor 2020
2396 d,l-K6L9 Amp1D Antimicrobial peptide 2022
2397 F(RI)2R Antimicrobial peptide 2022
2398 F(KW)2K Antimicrobial peptide 2022
2399 YU253434 Small molecule antibacterial agent 2020
2400 Dipicolylamine-containing carbazole derivatives combined with Zn2+ Antimicrobial peptide 2021
2401 Kaempferol-derived compound 52 Small molecule antibacterial agent 2020
2402 Bakuchiol derivative compound 28 Antimicrobial peptide 2021
2403 Aromatic-linked diamino acid AMP mimic 8j Antimicrobial peptide 2023
2404 AAV-qC10 Glycopeptide 2021
2405 PrAMP Bac7 (1–16) Antimicrobial peptide 2020
2406 6-pyrenyl PTM 6t Small molecule antibacterial agent 2018
2407 Imidazolidine-4-one derivative 3 Antimicrobial peptide 2020
2408 Rimomycin derivative 17 Glycopeptide 2023
2409 Honokiol/ Magnolol amphiphile 5i Antimicrobial peptide 2021
2410 Dimeric lysine alkylamide 3d Antimicrobial peptide 2018
2411 Nonivamide derivative 51 Small molecule antibacterial agent 2022
2412 Kynomycin Lipopeptide 2020
2413 3-(4-(cyclopentyloxy)phenyl)-5-(4-nitro-1H-imidazol-2-yl)-1,2,4-oxadiazole Small molecule antibacterial agent 2023
2414 4-[4-(Anilinomethyl)-3-phenylpyrazol-1-yl]benzoic acid derivative 44 Small molecule antibacterial agent 2023
2415 1,3-Diamino-7H-pyrrol[3,2-f]quinazoline derivative Small molecule antibacterial agent 2023
2416 Isoxazole (−)17j Small molecule antibacterial agent 2023
2417 Vancomycin-arginine conjugate Glycopeptide 2023
2418 MB076 Beta-lactamase inhibitor 2023
2419 Linear brevicidine Antimicrobial peptide 2023
2420 Linear laterocidine Antimicrobial peptide 2023
2421 Triazolylpyrimidinediol (triazolyl PD) 7a Small molecule antibacterial agent 2023
2422 Pyridine-Thiazole-Pleuromutilin 10b Pleuromutilin 2023
2423 Octapeptin C-02 Lipopeptide 2023
2424 2-substituted 3-hydroxy-1,6-dimethylpyridin-4(1H)-one–ciprofloxacin conjugate 5e Antivirulence agent 2023
2425 JMV7061 Beta-lactamase inhibitor 2022
2426 Halofuginone derivative 3 Small molecule antibacterial agent 2022
2427 Phenyl sulphide-based cationic amphiphile 17 Antimicrobial peptide 2022
2428 5-Amino-4-quinolone 111, antibacterial agent 123 Quinolone 2022
2429 Spiropyrimidinetrione 42 Small molecule antibacterial agent 2022
2430 N-Aryl mercaptopropionamide 29 Beta-lactamase inhibitor 2022
2431 Rifasutenizol Small molecule antibacterial agent 2022 Phase 3 (NCT05857163)
2432 Sansanmycin analogue 9 Antimicrobial peptide 2017
2433 Sansanmycin analogue 17 Antimicrobial peptide 2017
2434 5-Amino-1,3-dioxane-linked Novel Bacterial Topoisomerase Inhibitor (NBTI) 79 Small molecule antibacterial agent 2021
2435 Pyrimido[4,5-b]indole 18r Small molecule antibacterial agent 2021
2436 Tricyclic-2-quinolone 25 Small molecule antibacterial agent 2021
2437 6-Halopyridylmethylidene bromopyridyl 2 Beta-lactamase inhibitor 2021
2438 2,4-Dibromo-3-chloro-1-hydroxyphenazine 29 Small molecule antibacterial agent 2021
2439 Adenine–benzyltriazolo–pleuromutilin conjugate 35 Small molecule antibacterial agent 2020
2440 KL-L9P Antimicrobial peptide 2020
2441 Polyaminoisoprenyl derivative 5r/doxycycline combination Small molecule antibacterial agent 2020
2442 StRRL Antimicrobial peptide 2023
2443 Xanthohumol derivative IV15 Antimicrobial peptide 2023
2444 12-mer α-helical peptide 8b Antimicrobial peptide 2023
2445 Peptide 5a Antimicrobial peptide 2022
2446 Feleucin-K3 derived peptide K122 Antimicrobial peptide 2023
2447 Carbazole-oxadiazole 5g Membrane-active agent 2022
2448 Nitroimidazole derivative 4d Nitroimidazole 2022
2449 Benzothiazole-2-thiol compound 18b Membrane-active agent 2022
2450 Dioxonaphthoimidazolium 32 Small molecule antibacterial agent 2021
2451 N-Aryl-3-mercaptosuccinimide Antivirulence agent 2020
2452 Heteroaryl phosphonate compound 16 Beta-lactamase inhibitor 2019
2453 Pyridopyrimidine 14e Small molecule antibacterial agent 2019
2454 Trp-rich dodecapeptide 6 Antimicrobial peptide 2019
2455 7-nitrobenzoxadiazole IV-related compounds Small molecule antibacterial agent 2013
2456 Cephalosporin–fluoroquinolone prodrug 35 Beta-lactam 2019
2457 Cinchona alkaloid 48 Small molecule antibacterial agent 2019
2458 Pyrrolo-imidazolone 18d Small molecule antibacterial agent 2020
2459 (E)-3-(5-carboxy-2-fluorophenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one 73 Small molecule antibacterial agent 2020
2460 C8-linked pyrrolobenzodiazepine (PBD) 7, C8-linked pyrrolobenzodiazepine (PBD) 8 Small molecule antibacterial agent 2020
2461 Tideglusib and its analogues Antivirulence agent 2020
2462 Cyclic IDR-1018 Antimicrobial peptide 2020
2463 N-((1,3,6-trimethyl-4-oxo-1,4-dihydropyridin-2-yl)methyl)hexanamide 10d Antibiofilm agent 2020
2464 HSGN-218 Small molecule antibacterial agent 2020
2465 2,4-diamino-6-(4-tert-butylphenyl)-1,3,5-trazine (DATPT) Small molecule antibacterial agent 2022
2466 MsbA-IN-6 Drug efflux pump inhibitor 2022
2467 HSGN-94 Small molecule antibacterial agent 2022
2468 Linker-evolved-group-optimized LEGO-LPPO (lipophosphonoxin) 25 Antimicrobial peptide 2022
2469 Auranofin analogue Small molecule antibacterial agent 2019
2470 Mastoparan-R1 Antimicrobial peptide 2019
2471 Mastoparan-R4 Antimicrobial peptide 2019
2472 Thienopyrimidinone derivative Small molecule antibacterial agent 2019
2473 Pyrido[2,3-b]indole 17r Small molecule antibacterial agent 2020
2474 Chimeric macrocyclic peptide 3a Antimicrobial peptide 2021
2475 Corallopyronin A RNA polymerase inhibitor 1985 Preclinical
2476 Decatromicins (decatromicin A, decatromicin B) Antimicrobial peptide 1999
2477 Deoxyactagardine B Antimicrobial peptide 2010
2478 NVB302 Antimicrobial peptide 2009
2479 Desotamide A Antimicrobial peptide 2014
2480 Ethambutol Small molecule antibacterial agent 1961 Approved by FDA in 1967
2481 Flavomycin Natural product antibiotic 1980 Approved for veterinary use only in 1993
2482 Antibiotic FR900109 Natural product antibiotic 1983
2483 Griseolutin A Natural product antibiotic 1958
2484 Kirromycin Natural product antibiotic 1972
2485 Lassomycin Antimicrobial peptide 2014
2486 Lysobactin Antimicrobial peptide 1988
2487 Malacidin A Lipopeptide 2018
2488 Monensin Natural product antibiotic 1967 Approved for veterinary use only in 1975
2489 Mupirocin Natural product antibiotic 1971 Approved for topical use by FDA in 1997
2490 Hygromycin A Natural product antibiotic 1997
2491 Tur1A Antimicrobial peptide 2018
2492 Tur1B Antimicrobial peptide 2018
2493 Cacaoidin Antimicrobial peptide 2020
2494 Symbah-1 Antimicrobial peptide 2021
2495 Daunorubicin Natural product antibiotic 2023
2496 Ostruthin Natural product antibiotic 2023
2497 Benzamide 1j Small molecule antibacterial agent 2018
2498 Tun-X,X Small molecule antibacterial agent 2018
2499 Ruthenium red Small molecule antibacterial agent 2020
2500 Armeniaspirol A Antivirulence agent 2012
2501 Plantacyclin B21AG Antimicrobial peptide 2020
2502 Dephostatin Antivirulence agent 2020
2503 BacPROTAC Antivirulence agent 2023
2504 Chlorotonil A Macrolide 2007
2505 Suramin Small molecule antibacterial agent 2014
2506 Quinazolinone 34 Antivirulence agent 2022
2507 4-(4,7-DiMethyl-1,2,3,4-tetrahydroNaphthalene-1-yl)Pentanoic acid (DMNP) Antibiofilm agent 2021
2508 Enterocin A, Enterocin B Antimicrobial peptide 2023
2509 JCP276 Small molecule antibacterial agent 2022
2510 Loratadine Antivirulence agent 2022
2511 Imidazolium bromide salt NIM-Br 1a Small molecule antibacterial agent 2019
2512 Imidazolium bromide salt NIM-Br 1b Small molecule antibacterial agent 2019
2513 Imidazolium bromide salt NIM-Br 1c Small molecule antibacterial agent 2019
2514 Hydroquinone Natural product antibiotic 2021
2515 Bionectin F Natural product antibiotic 2022
2516 Imidazoquinoline 5f Small molecule antibacterial agent 2021
2517 Titanium/Hydroxyapatite Small molecule antibacterial agent 2023
2518 BRGP-001 Antimicrobial peptide 2023
2519 BRGP-005 Antimicrobial peptide 2023
2520 BRGP-006 Antimicrobial peptide 2023
2521 Caerin 1.1 Antimicrobial peptide 2023
2522 Benzofuran-triazine derivative 8e (2-benzothiazole) Small molecule antibacterial agent 2023
2523 1,2,3-triazole-thymol derivative 9 Small molecule antibacterial agent 2022
2524 Halicin Small molecule antibacterial agent 2019
2525 Amoxapine Small molecule antibacterial agent 2018
2526 Peptide P3 Antimicrobial peptide 2020
2527 Pept-in P2, Pept-in P33, and Pept-in P5 Antimicrobial peptide 2021
2528 Epithienamycin E Beta-lactam 1978
2529 Drosocin Antimicrobial peptide 1996
2530 Abierixin Natural product antibiotic 1985
2531 Albonoursin Antimicrobial peptide 2002
2532 Amicetin A Natural product antibiotic 1953 Preclinical
2533 Blasticidin S Natural product antibiotic 1957
2534 Bottromycin A2 Antimicrobial peptide 1955 Preclinical
2535 Bottromycin B2 Antimicrobial peptide 1955 Preclinical
2536 Brevimycin Natural product antibiotic 1970
2537 Brevistin Antimicrobial peptide 1975
2538 Carbomycin A Macrolide 1977 Preclinical
2539 Cepacin A Natural product antibiotic 1984
2540 Cepacin B Natural product antibiotic 1984
2541 Cephamycin C Beta-lactam 1973 Preclinical
2543 Cirratiomycin B Antimicrobial peptide 1982
2544 Colicin Z Natural product antibiotic 2019
2545 Deltamycin A1 Macrolide 1978
2546 Deltamycin A2 Macrolide 1978
2547 Denamycin Natural product antibiotic 1969
2548 Derinamycin Natural product antibiotic 1975
2549 Diazoquinomycin H Natural product antibiotic 1982
2550 Diumycin A Natural product antibiotic 1972
2551 Edeine A Natural product antibiotic 1970
2552 Ericamycin Natural product antibiotic 1966
2553 Erythronolide Macrolide 2005
2554 Ferensimycin Natural product antibiotic 1982
2555 Fomecin A Natural product antibiotic 1982
2556 Fortimicin A Aminoglycoside 1981
2557 Fridamycin Natural product antibiotic 2003
2558 Fucothricin Aminoglycoside 1974
2559 Furanomycin Natural product antibiotic 1998
2560 Fuscin Natural product antibiotic 1948
2561 Gallidermin Antimicrobial peptide 1988
2562 Geodin derivative 37 Natural product antibiotic 2022
2563 Griseomycin Macrolide 1953
2564 Grividomycin Streptogramin 1987
2565 Gunacin Natural product antibiotic 1979
2566 Hapalindole T Natural product antibiotic 2009
2567 Heliomycin Natural product antibiotic 1984
2568 Hexa-N-benzylneomycin Aminoglycoside 1973
2569 Hikizimycin Nucleoside analogue 1979
2570 Hodydamycin Antimicrobial peptide 1970
2571 Hormaomycin Natural product antibiotic 1990
2572 Hydroxynybomycin Natural product antibiotic 1977
2573 Ingramycin Natural product antibiotic 1971
2574 Inolomin Natural product antibiotic 1941
2575 Iodinin Natural product antibiotic 1945
2576 Juglomycin Natural product antibiotic 1971
2577 Juvenimicin A2 Macrolide 1976
2578 Juvenimicin A3 Macrolide 1973
2579 Kalafungin Natural product antibiotic 1968
2580 Kinamycin A Natural product antibiotic 1971
2581 Kinamycin B Natural product antibiotic 1971
2582 Lactaroviolin Natural product antibiotic 1947
2583 Lactoquinomycin A Natural product antibiotic 1976
2584 Lankamycin Macrolide 1994
2585 Lankacidin C Macrocycle 1971
2586 Lasalocid Natural product antibiotic 1979
2587 Lateriomycin Natural product antibiotic 1969
2588 Lateritiin Natural product antibiotic 1947
2589 Laterosporin Natural product antibiotic 1949
2590 Lavendulin Natural product antibiotic 1953
2591 Leucomycin A7 Macrolide 2010
2592 Leuseramycin Natural product antibiotic 1979
2593 Libramycin Natural product antibiotic 1974
2594 Licheniformin Natural product antibiotic 1947
2595 Lienomycin Macrolide 1980
2596 Lividomycin A Aminoglycoside 1972
2597 Longicatenamycin Antimicrobial peptide 1970
2598 Lonomycin Natural product antibiotic 1976
2599 Lysocellin Natural product antibiotic 1969
2600 Macarbomycin Natural product antibiotic 1973
2601 Macromomycin Antimicrobial peptide 1968
2602 Manumycin Natural product antibiotic 1994
2603 Balofloxacin Fluoroquinolone 2005 Approved in Korea
2604 AGXX Small molecule antibacterial agent 2023
2605 9-propionylmaridomycin Macrolide 1972
2606 Chimedermycin Natural product antibiotic 2022
2607 Megalomicin A Macrolide 1969
2608 Megovalicin D, megovalicin G, megovalicin H Natural product antibiotic 1988
2609 Chilaphylin Natural product antibiotic 1973
2610 Mepicycline Tetracycline 1962
2611 Metacycline (Rondomycin) Tetracycline 1961 Approved
2612 Sch 33256 Tetracycline 1987
2613 8-Methoxychlortetracycline Tetracycline 1987
2614 2-Methyl-L-arginine Natural product antibiotic 1976
2615 α-methylbiotin Natural product antibiotic 1972
2616 α-methyldethiobiotin Natural product antibiotic 1972
2617 Methylenomycin Natural product antibiotic 1974
2618 Methymycin Macrolide 1968
2619 Pikromycin Macrolide 1968
2620 Microcin proximity-dependent-inhibition (PDI) Antimicrobial peptide 2012
2621 Micromonosporin Macrolide 1947
2622 Mimosamycin Natural product antibiotic 1976
2623 Minimycin Natural product antibiotic 1972
2624 Minosaminomycin Aminoglycoside 1974
2625 Moracin C Natural product antibiotic 2012
2626 Chalcomoracin Natural product antibiotic 2012
2627 Olemorphocycline Tetracycline 1968 Approved in 1968 (Russia)
2628 Multhiomycin Antimicrobial peptide 1970
2629 Musettamycin Natural product antibiotic 1977
2630 Marcellomycin Natural product antibiotic 1977
2631 Mutalomycin Natural product antibiotic 1977
2632 Mutamicin Aminoglycoside 1974
2633 Mycelianamide Small molecule antibacterial agent 1948
2634 Mycinamicin Macrolide 1980
2635 Mycobacidin Natural product antibiotic 1952
2636 Mycocidin Natural product antibiotic 1945
2637 Myxopyronin Natural product antibiotic 1983
2638 Nannochelin Natural product antibiotic 1992
2639 Naphthyridinomycin Natural product antibiotic 1975
2640 Napyradiomycin Natural product antibiotic 1986
2641 Narbomycin Macrolide 2005
2642 Neomycin A Natural product antibiotic 1951
2643 Neonocardin Natural product antibiotic 1951
2644 Neoviridogrisein Natural product antibiotic 1979
2645 Netropsin Natural product antibiotic 1951
2646 Nigericin Natural product antibiotic 1951
2647 Nitrosporin Natural product antibiotic 1952
2648 Nocardamin Natural product antibiotic 1982
2649 Nogalamycin Natural product antibiotic 1965
2650 Norplicacetin Natural product antibiotic 1977
2651 Novenamine Aminocoumarin 1972
2652 Nybomycin Natural product antibiotic 1955
2653 Erythronolide A oxime Macrolide 1974
2654 Oleficin Natural product antibiotic 1971
2655 Oxamicetin Natural product antibiotic 1973
2656 Pactamycin Natural product antibiotic 1962
2657 Paromamine Aminoglycoside 1964
2658 Parvodicin Glycopeptide 1987
2659 U-77,802 and U-77,803 Natural product antibiotic 1988
2660 Notatin Beta-lactam 1942
2661 Penicillin N Beta-lactam 1953
2662 Penimepicycline Beta-lactam 1962
2663 Pentenomycin Natural product antibiotic 1973
2664 Pentenomycin analogues Natural product antibiotic 2019
2665 AVS-03d Natural product antibiotic 2008
2666 Pepthiomycin Antimicrobial peptide 1968
2667 Pholipomycin Natural product antibiotic 1977
2668 Phthiocol Natural product antibiotic 1946
2669 Violacein Natural product antibiotic 1946
2670 Prodigiosin Natural product antibiotic 1946
2671 Platenomycin A1 Macrolide 1974
2672 Pleocidin Aminoglycoside 1952
2673 Pleurotin Natural product antibiotic 1947
2674 Plumbagin Natural product antibiotic 2016
2675 Polymyxin A Lipopeptide 1949
2676 Polymyxin D Lipopeptide 1947
2677 Polymyxin F Lipopeptide 1977
2678 Polymyxin M Antimicrobial peptide 2003
2679 Polymyxin P Antimicrobial peptide 1969
2680 Polymyxin S1 Antimicrobial peptide 1977
2681 Polymyxin T1 Antimicrobial peptide 1977
2682 Polypeptin Antimicrobial peptide 1948
2683 Polyporin Natural product antibiotic 1944
2684 Porothramycin Natural product antibiotic 1988
2685 Portmicin Natural product antibiotic 1987
2686 Prasinomycin Natural product antibiotic 1968
2687 Prenomycin Natural product antibiotic 1974
2688 Proactinomycin Natural product antibiotic 1949
2689 Platenolide Macrolide 1978
2690 Proticin Natural product antibiotic 1972
2691 Protoanemonin Antivirulence agent 1945
2692 Angustmycin A Natural product antibiotic (adenosine analogues) 1958
2693 Pterygospermin Natural product antibiotic 1946
2694 Puberulic acid Natural product antibiotic 1947
2695 Puromycin Aminoglycoside 1979
2696 Purpuromycin Protein synthesis inhibitor 1974
2697 Pyo Quinolone 1945
2698 Pyoverdin Natural product antibiotic 2024
2699 Pyracrimycin Natural product antibiotic 1971
2700 Quinacillin Beta-lactam 1963
2701 Azalomycin F Macrolide 1995
2702 CP-84,657 Natural product antibiotic 1990
2703 Salivabactin Antimicrobial peptide 2024
2704 Compound with N-[2-(2-chlorophenoxy)ethyl]aniline core Small molecule antibacterial agent 2023
2705 Zosurabalpin Antimicrobial peptide 2024 Phase 1 (NCT05614895)
2706 Quinaldopeptin Natural product antibiotic 1990
2707 Rabelomycin Natural product antibiotic 1970
2708 Racemomycin Streptothricin 1990
2709 Ractinomycin Natural product antibiotic 1957
2710 Raphanin Natural product antibiotic 1947
2711 Requinomycin Natural product antibiotic 1972
2712 Resistaphylin Natural product antibiotic 1971
2713 Rhodirubin Natural product antibiotic 1977
2714 Rhodocidin Natural product antibiotic 1952
2715 Cyanomycin Natural product antibiotic 1958
2716 Rhodomycetin Natural product antibiotic 1951
2717 Rhodomycin Natural product antibiotic 1953
2718 Rifamazine Rifamycin 1975
2719 Rinamycin Natural product antibiotic 1975
2720 Ristocetin Glycopeptide 1956
2721 Rubradirin Natural product antibiotic 1965
2722 Rubromycin Natural product antibiotic 1953
2723 Rufomycin Antimicrobial peptide 1962
2724 Saframycin Mx1 Natural product antibiotic 1987
2725 Sakyomicin Natural product antibiotic 1984
2726 Salinomycin Natural product antibiotic (polyether antibiotic, ionophore) 1974
2727 Sancycline Tetracycline 1962
2728 Sannamycin Aminoglycoside 1980
2729 Scopafungin Natural product antibiotic 1971
2730 Schlerothricin Streptothricin 1969
2731 Selenomycin Natural product antibiotic 1972
2732 Septamycin Natural product antibiotic 1975
2733 Shincomycin Macrolide 1965
2734 Showdomycin Nucleoside analogue 1964
2735 Sibanomicin Natural product antibiotic 1988
2736 Siomycin Antimicrobial peptide 1961
2737 Sorbistin Aminoglycoside 1976
2738 Sparsomycin Natural product antibiotic 1962
2739 Spirocardin Natural product antibiotic 1989
2740 Sporaviridin Natural product antibiotic 1989
2741 Staphylococcin Antimicrobial peptide 1975
2742 Staphylomycin S Streptogramin 1954
2743 Stilbellin Antimicrobial peptide 1971
2744 Streptocin Natural product antibiotic 1949
2745 Streptogramin Streptogramin 1953
2746 Streptolin Streptothricin 1947
2747 Streptothricin Streptothricin 1942
2748 Streptovaricin Natural product antibiotic 1957
2749 Steptovirudin Natural product antibiotic 1975
2750 Striatin Natural product antibiotic 1976
2751 Subtenolin Natural product antibiotic 1945
2752 Subtilin Antimicrobial peptide 1945
2753 Sulfactin Natural product antibiotic 1947
2754 Sulfocillin Beta-lactam 1971
2755 Sulfurmycin Natural product antibiotic 1982
2756 Suncillin Beta-lactam 1968
2757 Suzukacillin Antimicrobial peptide 1965
2758 Teichomycin A1 Glycopeptide 1978
2759 Teichomycin A2 Glycopeptide 1978
2760 Telomycin Antimicrobial peptide 1957
2761 Tenebrimycin Aminoglycoside 1972
2762 Tetranactin Natural product antibiotic 1971
2763 Thermomycin Natural product antibiotic 1951
2764 Thianosine Polymyxin 1971
2765 Thienamycin Beta-lactam 1979
2766 Thiopeptin Antimicrobial peptide 1972
2767 Tirandamycin Natural product antibiotic 1971
2768 Tolypomycin Rifamycin 1971
2769 Triostin Natural product antibiotic 1968
2770 Tuberactin Antimicrobial peptide 1968
2771 Tubercidin Natural product antibiotic 1957 Preclinical
2772 Tumimycin Natural product antibiotic 1972
2773 Umbrinomycin Naphthoquinone 1970
2774 Unphenelfamycin Natural product antibiotic 1989
2775 Ustin Natural product antibiotic 1953
2776 Valinomycin Antimicrobial peptide 1955
2777 Variamycin Natural product antibiotic 1971
2778 Variapeptin Antimicrobial peptide 1990
2779 Viomycin Natural product antibiotic 1951 Approved in 1953
2780 Viridogrisein Streptogramin 1958
2781 Xanthocillin X Natural product antibiotic 1954
2782 Xanthomycin A Tetracycline 1981
2783 Yemenimycin Antimicrobial peptide 1971
2784 Zervamicin Antimicrobial peptide 1974
2785 Zorbamycin Glycopeptide 1971
2786 Zorbonomycin Glycopeptide 1971
2787 VanQAmC10 Glycopeptide 2020
2788 RO7196472 Antimicrobial peptide 2024
2789 RO7075573 Antimicrobial peptide 2024 Preclinical
2790 Fusidic acid prodrug Fusidane 2023
2791 Mycoplanecin Natural product antibiotic 1983
2792 Amycobactin Natural product antibiotic 2020
2793 Kitamycobactin Natural product antibiotic 2020
2794 Streptomycobactin Antimicrobial peptide 2020
2795 MEndoB Bacteriophage and/or bacteriophage-derived product 2024
2796 NCR094 Antimicrobial peptide 2024
2797 NCR992 Antimicrobial peptide 2024
2798 Hypochlorous acid producing electrochemical bandage (HOCl e-bandage) DNA synthesis inhibitor 2007
2799 Prodrug methyl tris diazeniumdiolate (prodrug MD3) Membrane-active agent 2024
2800 φPaP11-13 Bacteriophage and/or bacteriophage-derived product 2024
2801 Z-Ethylthio enynone Antivirulence agent 2024
2802 Maleimide-diselenide hybrid compound (YH7), YH7 Small molecule antibacterial agent 2024
2803 Ethylenediaminetetraacetic acid (EDTA)/polymyxin B Small molecule antibacterial agent 2024
2804 Secretion Modification Region (SMRwt) peptide Antimicrobial peptide 2024
2805 Compound IV (4-[(4-methoxyphenyl)methylsulfanyl]−7-nitro-2,1,3-benzoxadiazole) Small molecule antibacterial agent 2023
2806 Fisetin Antivirulence agent 2023
2807 MSU-43085 Small molecule antibacterial agent 2023
2808 Tafenoquine Membrane-active agent 2021
2809 Amidochelocardin, 2-carboxamido-2-deacetyl-chelocardin Tetracycline 2015
2810 Stattic Small molecule antibacterial agent 2023
2811 8-O-methyltetrangomycin (MTN) and 8-O-methyltetrangulol (MTL) Natural product antibiotic 2023
2812 CU032 Drug efflux pump inhibitor 2023
2813 CU232 Drug efflux pump inhibitor 2023
2814 CU244 Drug efflux pump inhibitor 2023
2815 EPM35 Drug efflux pump inhibitor 2018
2816 (Z)-13-methyltetra-4-decenoic acid ((Z)-4C-14:1) Membrane-active agent 2023
2817 Romsacin Antimicrobial peptide 2023
2818 Bactobolin Folate synthesis inhibitor 2023
2819 NSC367428 Folate synthesis inhibitor 2023
2820 B59 Small molecule antibacterial agent 2023
2821 QingXiaoWuWei (QXWWD) Natural product antibiotic 2023
2822 Ultra-short palmitoylated 5-mer phenylalanine:lysine (FK5P) Antimicrobial peptide 2020
2823 S-342-3 Antibiofilm agent 2023
2824 Thiolato-bridged dinuclear ruthenium(II)-arene compound 5 Small molecule antibacterial agent 2023
2825 Thiolato-bridged dinuclear ruthenium(II)-arene compound 6 Small molecule antibacterial agent 2023
2826 Sophorolipid-capped gold nanoparticles (AuNPs-SL) Small molecule antibacterial agent 2023
2827 Cecropin HC1 (Hill-Cec1) Antimicrobial peptide 2022
2828 Cecropin HC10 (Hill-Cec10) Antimicrobial peptide 2022
2829 Shikonin Natural product antibiotic 2015
2830 WQ-3154 Fluoroquinolone 2023
2831 WQ-3810, KPI-10, WQ-3813 Fluoroquinolone 2014 Phase 1
2832 MMV676501 (Pbc 1) Small molecule antibacterial agent 2023
2833 MMV676388 (Pbc 2) Small molecule antibacterial agent 2023
2834 MMV002817 (Pbc 3) Small molecule antibacterial agent 2023
2835 MMV688508 (Pbc 5) Oxazolidinone 2023
2836 MMV024937 (Pbc 6) Small molecule antibacterial agent 2023
2837 MMV272144 (Pbc 8) Small molecule antibacterial agent 2023
2838 MMV021013 (Pbc 9) Small molecule antibacterial agent 2023
2839 SMJ-5 Drug efflux pump inhibitor 2023
2840 Cesin A Antimicrobial peptide 2022
2841 Coli myophage (Killian) Bacteriophage and/or bacteriophage-derived product 2023
2842 Tricyclic amide NBTI (N-(2-((9-fluoro-4-oxo-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)methyl)- trans -1,3-dioxan-5-yl)-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carboxamide) DNA synthesis inhibitor 2023
2843 Eugenol Small molecule antibacterial agent 2023
2844 NCL195 Small molecule antibacterial agent 2017
2845 KKL-55 Small molecule antibacterial agent 2013
2846 HC2210 Nitroimidazole 2023
2847 AJ-037, AJ-039, and AJ-206 Antimicrobial peptide 2023
2848 RP557 Antimicrobial peptide 2019
2849 Famotidine Membrane-active agent 2023
2850 Silver-tellurite combination Small molecule antibacterial agent 2022
2851 MJ-22 Small molecule antibacterial agent 2023
2852 B6 Small molecule antibacterial agent 2012
2853 Ceftazidime-decorated gold nanoparticles (CAZ_Au NPs) Membrane-active agent 2023
2854 Artificial-Bp7e6 endolysin (Art-Bp7e6) Bacteriophage and/or bacteriophage-derived product 2023
2855 Wollamide B Antimicrobial peptide 2014
2856 Acidicin P Antimicrobial peptide 2022
2857 Phosphonoalamide F Natural product antibiotic 2023
2858 NH125, 1-benzyl-3-cetyl-2-methylimidazolium iodide Small molecule antibacterial agent 2000
2859 CY-158-11 Antibiofilm agent 2023
2860 GE81112 A Antimicrobial peptide 2006
2861 ClyQ Bacteriophage and/or bacteriophage-derived product 2023
2862 PlyKp104 Bacteriophage and/or bacteriophage-derived product 2023
2863 Antibiotic 2B5 Antibiofilm agent 2023
2864 Baicalein Membrane-active agent 2005
2865 Thymol-decorated gold nanoparticle (Thymol_Au NPs) Membrane-active agent 2023
2866 Secreted antigen A (SagA) Cell wall synthesis inhibitor 2023
2867 Heterocyclic iodonium salt analogue 3a Small molecule antibacterial agent 2023
2868 Flufenamic acid Membrane-active agent 2023
2869 NITD-916 Small molecule antibacterial agent 2015
2870 APC148 Beta-lactamase inhibitor 2020 Phase 1 (NCT06360640)
2871 APL-2301 Membrane-active agent 2024 Phase 1 (to begin in Australia in 2024)
2872 PF-07612577 (avibactam tomilopil [ARX-1796] + ceftibuten) Beta-lactam + beta-lactamase inhibitor 2023 Phase 1 (NCT05554237)
2873 KSP-1007+meropenem Beta-lactam + beta-lactamase inhibitor 2023 Phase 1 (NCT05226923)
2874 R327 (RECCE 327) Membrane-active agent 2023 Phase 1/Phase 2 (ACTRN12623000056695; ACTRN12623000448640; ACTRN12621001313820)
2875 RG6319, GDC-5780 Small molecule antibacterial agent 2022 Phase 1 (ISRCTN16073754)
2876 BV100 (Mycobutin) Rifamycin 2022 Phase 1 (NCT05685615)
2877 FL058/meropenem Beta-lactam + beta-lactamase inhibitor 2023 Phase 2 (NCT05060419)
2878 Gallium citrate (AR-501) Small molecule antibacterial agent 2011 Phase 2 (NCT0366614)
2879 Nacubactam/Aztreonam (OP0595/Aztreonam) Beta-lactam + beta-lactamase inhibitor 2015 Phase 3 (NCT05887908)
2880 Cefepime + Tazobactam Beta-lactam + beta-lactamase inhibitor 2018 Phase 3 (NCT03630081)
2881 APT-CF phage (WRAIR-PAM-CF1) Bacteriophage and/or bacteriophage-derived product 2022 Phase 2 (NCT05453578)
2882 AP-PA02 Bacteriophage and/or bacteriophage-derived product 2023 Phase 2 (NCT05616221)
2883 CF-370 Bacteriophage and/or bacteriophage-derived product 2023 Preclinical
2884 CMTX101 Antibody 2023 Phase 1 (NCT06159725)
2885 SER-155 Natural product antibiotic 2022 Phase 1 (NCT04995653)
2886 SNIPR001 Bacteriophage and/or bacteriophage-derived product 2023 Phase 1 (NCT05277350)
2887 TP-102 Bacteriophage and/or bacteriophage-derived product 2022 Phase 2 (NCT05948592)
2888 BX004 Bacteriophage and/or bacteriophage-derived product 2023 Phase 2 (NCT05010577)
2889 F598 Antibody 2013 Phase 2 (NCT03222401)
2890 LBP-EC01 Bacteriophage and/or bacteriophage-derived product 2022 Phase 2 (NCT05488340)
2891 Macozinone (MCZ; PBTZ169) Small molecule antibacterial agent 2014 Phase 2 (NCT03334734)
2892 SPR720 (phosphate prodrug of SPR719) Small molecule antibacterial agent 2018 Phase 2 (NCT05496374)
2893 BB2-50F Antivirulence agent 2021
2894 TBA-7371 Small molecule antibacterial agent 2014 Phase 2 (NCT04176250)
2895 Salifungin Membrane-active agent 2024
2896 Conjugate 16 (22-[4-(6-((6-(Piperazin-1-yl)-9H-purin-9-yl)methyl)pyridin-3-yl)-1H-1,2,3-triazol-1-yl]-22-deoxypleuromutilin) Pleuromutilin 2024
2897 Meropenem/ANT3310 Beta-lactam + beta-lactamase inhibitor 2024 Phase 1 (NCT05905913)
2898 Mavintramycin A Protein synthesis inhibitor 2024
2899 Cresomycin Protein synthesis inhibitor 2024
2900 Autoinducing peptide (AIP II, AIP IV, and AIP V) Antivirulence agent 2024
2901 Compound 23 (4-(4-(Hydroxymethyl)phenyl)-3-(1H-tetrazol-5-yl)pyridine-2-sulfonamide) Beta-lactamase inhibitor 2022
2902 Epifadin Membrane-active agent 2024
2903 Reutericyclin A Membrane-active agent 2000
2904 Lugdunin Antimicrobial peptide 2016
2905 Metamycin C Small molecule antibacterial agent 2019
2906 Metamycin D Small molecule antibacterial agent 2019
2907 Epilancin 15X Antimicrobial peptide 2005
2908 PQQ16P Drug efflux pump inhibitor 2018
2909 NSC 33353 Drug efflux pump inhibitor 2017
2910 NSC 305798 Drug efflux pump inhibitor 2017
2911 BDM91288 Drug efflux pump inhibitor 2023
2912 BDM91270 Drug efflux pump inhibitor 2023
2913 Pyridomycin Natural product antibiotic 2012
2914 Vancomycin-templated DEL-derived vancomycin analogue Glycopeptide 2024
2915 Lusutrombopag Membrane-active agent 2024
2916 Silver N-heterocyclic carbene halido complex Small molecule antibacterial agent 2024
2917 Oct-TriA5 (tridecaptin A5 derivative) Antimicrobial peptide 2024
2918 Bosutinib Small molecule antibacterial agent 2024
2919 Compound 162 Small molecule antibacterial agent 2024
2920 YFJ-36 (compound 86b) Beta-lactam 2024
2921 Compound 681 Small molecule antibacterial agent 2024
2922 2-Phenoxyalkylhydrazide benzoxazole derivative 26c (N′-(Benzo[d]oxazo-2-yl)-2-(4-fluorophenoxy)acetylhydrazine) Antivirulence agent 2024
2923 Cloacaenodin Antimicrobial peptide 2023
2924 Compound III13 (2-phenyl-1H-phenanthro[9,10-d]imidazole-antimicrobial peptide (AMP) mimic conjugate III13) Membrane-active agent 2024
2925 Compound j9 (AF-353 derivative), 5-(4-(Cyclopropylmethoxy)-5-iodo-2-isopropylphenoxy)pyrimidine-2,4-diamine Small molecule antibacterial agent 2024
2926 SG-B-52 Small molecule antibacterial agent 2024
2927 SG-B-22 Small molecule antibacterial agent 2024
2928 BGAz 002 (azetidine derivative) Mycolic acid synthesis inhibitor 2024
2929 Neomycin-X8 combination Small molecule antibacterial agent 2024
2930 Compound 4t (1,2,4-oxadiazole substituent derivative 4t) Membrane-active agent 2024
2931 V-triguan (Vancomycin-polyguanidino dendrimer conjugate) Glycopeptide 2024
2932 DDC18–8A Membrane-active agent 2022
2933 JSF-3269 (benzothiophene derivative) Nitrofuran 2024
2934 Compound 6f (2-(4-(3-((6-chloro-1-isopropyl-1H-benzo[d]imidazol-2-yl)amino)-2-hydroxypropoxy)phenyl)acetonitrile) Antivirulence agent 2024
2935 CGS19 (LARVARRVIRFIRRAW-NH2) Antimicrobial peptide 2024
2936 CGS20 (RRRLARRLIFFIRRAW-NH2) Antimicrobial peptide 2024
2937 Y40 (ML346 analogue) Antivirulence agent 2024
2938 ML346 Antivirulence agent 2022
2939 BDM88855 Drug efflux pump inhibitor 2022
2940 MBX-3132 Drug efflux pump inhibitor 2016
2941 Ubonodin RNA synthesis inhibitor 2020
2942 Citrocin RNA synthesis inhibitor 2019
2943 JSF-4088 Nitrofuran 2019
2944 Amylocyclicin Antimicrobial peptide 2014
2945 Chicken cathelicidin-2 (CATH-2) Antimicrobial peptide 2009
2946 Antibiotic 1717 Small molecule antibacterial agent 2017
2947 Antibiotic 2093 Small molecule antibacterial agent 2017
2948 Antibiotic 2144 Small molecule antibacterial agent 2017
2949 MPC-1 Beta-lactamase inhibitor 2017
2950 Lactolisterin BU Antimicrobial peptide 2017
2951 NP108 (Luminaderm) Antimicrobial peptide 2017 Preclinical
2952 SPI009 (1-((2,4-dichlorophenethyl)amino)-3-phenoxypropan-2-ol) Small molecule antibacterial agent 2017
2953 Cyclic lipopeptide 4 (CLP-4) Lipopeptide 2017
2954 LPC-069 Lipopolysaccharide synthesis inhibitor 2017
2955 LPC-058 Lipopolysaccharide synthesis inhibitor 2016
2956 WCK-5153 Cell wall synthesis inhibitor 2017
2957 INP0341  Antivirulence agent 2017
2958 INP1750  Antivirulence agent 2017
2959 INP1855 Antivirulence agent 2017
2960 Blasticidin P10 Nucleoside analogue 2017
2961 Blasticidin derivative 16 Nucleoside analogue 2024
2962 Blasticidin derivative 20 Nucleoside analogue 2024
2963 REDX06213  DNA synthesis inhibitor 2017
2964 REDX07623 DNA synthesis inhibitor 2017
2965 Toremifene  Membrane-active agent 2017
2966 Arenicin-3 derivative N4 (N4) Antimicrobial peptide 2016 Preclinical
2967 RBx 11760 Oxazolidinone 2016
2968 ND-10885 (Compound 2) Small molecule antibacterial agent 2016
2969 CMA3 Antimicrobial peptide 2015
2970 Campynexin A Small molecule antibacterial agent 2015
2971 Campynexin B Small molecule antibacterial agent 2015
2972 Campynexin C Small molecule antibacterial agent 2015
2973 Campynexin D Small molecule antibacterial agent 2015
2974 Campynexin E Small molecule antibacterial agent 2015
2975 T9W Antimicrobial peptide 2015
2976 Pyridineimidazole compound 1 Small molecule antibacterial agent 2015
2977 Pyridineimidazole compound 2 Small molecule antibacterial agent 2015
2978 VXc-486 (prodrug pVXc-486) DNA synthesis inhibitor 2015
2979 PVP-SE1gp146 Bacteriophage and/or bacteriophage-derived product 2012
2980 LoGT-008  Bacteriophage and/or bacteriophage-derived product 2014
2981 Cerecidin A7 Antimicrobial peptide 2014
2982 AmiBA2446 Bacteriophage and/or bacteriophage-derived product 2013
2983 Maculatin 1.1 Antimicrobial peptide 2013
2984 Rattusin  Antimicrobial peptide 2013
2985 Pep19-2.5 Antimicrobial peptide 2013 Preclinical
2986 SM-295291 Beta-lactam 2013 Preclinical
2987 SM-369926 Beta-lactam 2013 Preclinical
2988 NVC-422 (Aganocide®, Auriclosene) Antivirulence agent 2011 Phase 2 (NCT01367314; NCT00781339; NCT01532336; NCT01877694; NCT01243125)
2989 18-β-Glycyrrhetinic Acid (GRA) Antivirulence agent 2013
2990 NK-18 Antimicrobial peptide 2013
2991 MC-1 Beta-lactam 2010
2992 Aminododecanoyl-lysyl-[aminodecanoyl-lysyl]5 (α12-5α10) Antimicrobial peptide 2012
2993 Compound 1 Small molecule antibacterial agent 2012
2994 Compound 2 Small molecule antibacterial agent 2012
2995 Signermycin B Antivirulence agent 2012
2996 Polybia-CP Antimicrobial peptide 2012
2997 Loureirin A Natural product antibiotic 2024
2998 Usnic acid Natural product antibiotic 1948
2999 Croconazole Small molecule antibacterial agent 2012
3000 Diffocin Antimicrobial peptide 2012
3001 Lactococcin 972 Antimicrobial peptide 2012
3002 JEDI-1444 Small molecule antibacterial agent 2024
3003 EBL-3647 Small molecule antibacterial agent 2024
3004 EBL-3599 Small molecule antibacterial agent 2024
3005 eAmSPC 2593 Aminoglycoside 2024
3006 eAmSPC 2694 Aminoglycoside 2024
3007 Argyrin B  Antimicrobial peptide 1996
3008 NDM1i-1F and NDM1i-1G Beta-lactamase inhibitor 2021
3009 Burkfloxacin Fluoroquinolone 1980
3010 Flucytosine (prodrug) Antivirulence agent 2019
3011 M21 Small molecule antibacterial agent 2018
3012 Fusaricidin Antimicrobial peptide 1996
3013 Streptothricin BI and Streptothricin BII Streptothricin 1948
3014 Exfoliatin Natural product antibiotic 1952
3015 Roseomycin Streptothricin 1953
3016 Basic antibiotic from strain No. 24 Streptothricin 1953
3017 3-N-Nonylpyrazole Natural product antibiotic 1954
3018 Actinoleukin Natural product antibiotic 1956
3019 Griseolutein B Natural product antibiotic 1953
3020 Mycospocidin Natural product antibiotic 1957
3021 Elaiomycin Natural product antibiotic 1957
3022 Aburamycin Natural product antibiotic 1957
3023 Althiomycin Natural product antibiotic 1957
3024 Cellocidin Natural product antibiotic 1958
3025 Latumcidin Natural product antibiotic 1958
3026 Alboverticillin Antimicrobial peptide 1958 Preclinical (1967)
3027 Dextromycin Aminoglycoside 1958
3028 Virocidin Natural product antibiotic 1958
3029 Neocidin Natural product antibiotic 1959
3030 Esperin Antimicrobial peptide 1959
3031 Taitomycin Antimicrobial peptide 1959
3032 δ-Hydroxy-γ-oxo-L-norvaline (HON) Natural product antibiotic 1960
3033 Bovinocidin Natural product antibiotic 1960
3034 Tubermycin A and Tubermycin B Natural product antibiotic 1958
3035 Zygomycin B Aminoglycoside 1961
3036 Bandamycin Natural product antibiotic 1961
3037 Antibiotic A-59 Natural product antibiotic 1961
3038 Bacimethrin Natural product antibiotic 1961
3039 Antibiotic K-288 Natural product antibiotic 1961
3040 Gougerotin Natural product antibiotic 1962
3041 A-418-Z4 Natural product antibiotic 1962
3042 Tuberin Antimicrobial peptide 1962
3043 Griseococcin Natural product antibiotic 1962
3045 Succinimycin Natural product antibiotic 1963
3046 Cirramycin Macrolide 1963
3047 Emimycin Nucleoside analogue 1963
3048 Pillaromycin Natural product antibiotic 1964
3049 Pyrrolnitrin Natural product antibiotic 1964
3050 Danomycin Antimicrobial peptide 1964 Preclinical
3051 Cranomycin Natural product antibiotic 1964
3052 Lancovutide Antimicrobial peptide 1964
3053 Proceomycin Natural product antibiotic 1964
3054 Macrocin Macrolide 1964
3055 Laurusin Natural product antibiotic 1965
3056 Polychlorosubtilin Natural product antibiotic 1965
3057 Antibiotic R-468 Natural product antibiotic 1965
3058 Aztreonam lysine (Cayston) Beta-lactam 2010 Approved by FDA in 2010
3059 Lolamicin Small molecule antibacterial agent 2024
3060 Ceftibuten + VNRX-7145 Beta-lactam + beta-lactamase inhibitor 2022 Phase 1 (NCT04243863)
3061 Ertapenem + Zidebactam Beta-lactam + beta-lactamase inhibitor 2022 Phase 1 (NCT05645757)
3062 Coumermycin A2 DNA synthesis inhibitor 1965
3063 Aquayamycin Natural product antibiotic 1968
3064 SF-701 Streptothricin 1968
3065 Tetra-N-4-chlorobenzyl kanamycin Aminoglycoside 1968
3066 E-749-C Streptothricin 1968
3067 MC21-A (C58) Natural product antibiotic 2003
3068 Cervimycin C Natural product antibiotic 2024
3069 Ursoricin Antimicrobial peptide 2024
3070 LEI-800 DNA synthesis inhibitor 2024
3071 SM-5 Cell wall synthesis inhibitor 2024
3072 Prolixicin Antimicrobial peptide 2024
3073 Kobenomycin Antimicrobial peptide 1968
3074 Citromycin Streptothricin 1969
3075 Coriolin  Natural product antibiotic 1969
3076 Matchamycin Natural product antibiotic 1970
3077 S-520  Natural product antibiotic 1970
3078 Janiemycin Antimicrobial peptide 1970
3079 Boseimycin Streptothricin 1970
3080 Neopluramycin Natural product antibiotic 1970
3081 Leucylnegamycin Protein synthesis inhibitor 1971
3082 YA 56 Natural product antibiotic 1971
3083 Fumarylcarboxyamido-L-2,3-diaminopropionyl-L-alanine Antimicrobial peptide 1972
3084 Antibiotic No. 5879 Natural product antibiotic 1972
3085 Antibiotic 24010 B-1 Streptothricin 1972
3086 Jolipeptin Antimicrobial peptide 1972
3087 Cephacetrile Beta-lactam 1972
3088 Cryomycin Antimicrobial peptide 1972
3089 Actinotiocin Antimicrobial peptide 1973
3090 SP-351 Natural product antibiotic 1973
3091 Myomycin Aminoglycoside 1973
3092 XK-19-2 Antimicrobial peptide 1973
3093 Kuwaitimycin Antimicrobial peptide 1973
3094 Magnesidin Natural product antibiotic 1973
3095 Aminodeoxybutirosin Aminoglycoside 1973
3096 Butirosin Aminoglycoside 1972 Preliminary human studies (1975)
3097 Acidolin  Antimicrobial peptide 1974
3098 Antibiotic R4H Streptothricin 1974
3099 XK-46 Natural product antibiotic 1974
3100 NRCS-15 Antimicrobial peptide 1974
3101 ASK-753 Protein synthesis inhibitor 1969
3102 Baciphelacin Natural product antibiotic 1975
3103 Mannopeptin  Glycopeptide 1975
3104 AB-65 Glycopeptide 1975
3105 Antibiotic SS-228 Y Natural product antibiotic 1975
3106 Destomycin C Aminoglycoside 1975
3107 Antibiotic complex 61-26 Antimicrobial peptide 1975
3108 Antibiotic TL-119 Antimicrobial peptide 1975
3109 Asukamycin Natural product antibiotic 1976
3110 Antibiotic B-43 Antimicrobial peptide 1976
3111 Aplasmomycin Macrolide 1976
3112 Efrotomycin Protein synthesis inhibitor 1976
3113 Octapeptin C1 Lipopeptide 1976
3114 Gardimycin Antimicrobial peptide 1976
3115 Antibiotic G-52 Aminoglycoside 1976
3116 Aurantinin Membrane-active agent 1976
3117 Laterosporamine Natural product antibiotic 1976
3118 C-2801X Beta-lactam 1976
3119 Lenoremycin Natural product antibiotic 1975
3120 XK-90 Natural product antibiotic 1976
3121 K-52 A Natural product antibiotic 1976
3122 Cinodine Natural product antibiotic 1977
3123 A26771B Macrolide 1977
3124 Glycinothricin Streptothricin 1977
3125 OS-1804 Natural product antibiotic 1977
3126 Ribosylparomamine Aminoglycoside 1977
3127 Dityromycin Antimicrobial peptide 1977
3128 KT-151 Natural product antibiotic 1977
3129 K-52 B Natural product antibiotic 1977
3130 Sequanamycin 9 Macrolide 2023
3131 Sequanamycin A Macrolide 1969
3132 QPX7831 (Prodrug of QPX7728) Beta-lactamase inhibitor 2021 Phase 1 (NCT04578873, NCT06157242, NCT06079775)
3133 GE82832 Antimicrobial peptide 2006
3134 Ionomycin Natural product antibiotic 1978
3135 AA-57 Natural product antibiotic 1978
3136 PS-5 Beta-lactam 1978
3137 G2201-C Natural product antibiotic 1978
3138 Tolypomycin Y RNA synthesis inhibitor 1978
3139 Setomimycin Natural product antibiotic 1978
3140 A-10947 Antimicrobial peptide 1979
3141 2-Hydroxy-5-iminoazacyclopent-3-ene hydrochloride Natural product antibiotic 1979
3142 Heneicomycin Protein synthesis inhibitor 1979
3143 MM 19290 Natural product antibiotic 1979
3144 Permetin Antimicrobial peptide 1979
3145 Dactimycin Aminoglycoside 1979
3146 Staphcoccomycin Macrolide 1979
3147 Tf-26Vx Natural product antibiotic 1979
3148 Azureomycin B Natural product antibiotic 1979
3149 Pisiferic acid Natural product antibiotic 1978
3150 Sporaricin A Aminoglycoside 1979
3151 Antibiotic U-58,431 Natural product antibiotic 1980
3152 1-Deamino-1-hydroxyxylostasin Aminoglycoside 1980
3153 B-1008 Natural product antibiotic 1980
3154 Bu-2545 Lincosamide 1980
3155 3-Amino-3-deoxy-α-D-glucopyranosyl-α-D-glucopyranoside Natural product antibiotic 1980
3156 Heptelidic acid Natural product antibiotic 1980
3157 FR-900137 Cell wall synthesis inhibitor 1980
3158 Antlermicin A Natural product antibiotic 1980
3159 Bu-2313 Aminoglycoside 1980
3160 FR-900130 Natural product antibiotic 1980
3161 Clazamycin B Membrane-active agent 1979
3162 Repromicin Macrolide 1977
3163 Dnacin B1 Natural product antibiotic 1980
3164 Antibiotic 6016 Membrane-active agent 1980
3165 U-60,394 Natural product antibiotic 1980
3166 4-N-Glycyl sannamycin C Aminoglycoside 1980
3167 SF-1961 Natural product antibiotic 1980
3168 SF-1771 Natural product antibiotic 1980
3169 K-82 Natural product antibiotic 1980
3170 Funicin Natural product antibiotic 1980
3171 Toromycin Natural product antibiotic 1980
3172 Imidazo [4,5b] [1,8] naphthyridine derivative Small synthetic molecule 1980
3173 Kijanimicin Natural product antibiotic 1981
3174 Isosulfazecin Beta-lactam 1981
3175 Rubeomycin Natural product antibiotic (anthracycline) 1981
3176 Asparenomycin Beta-lactam (carbapenem) 1981
3177 Sulfazecin Beta-lactam (monobactam) 1981
3178 9-Epi-leucomycin A5 Macrolide 1981
3179 Haloquinone Natural product antibiotic 1981
3180 Oganomycin A Beta-lactam (cephamycin) 1981
3181 Pyrrolomycin B Natural product antibiotic (protonophore) 1981
3182 Antibiotic 6643-X Beta-lactam (carbapenem) 1982
3183 C-19393 E5 Beta-lactam (carbapenem) 1982
3184 AT-265 Protein synthesis inhibitor 1982
3185 Cyanocycline A DNA synthesis inhibitor 1982
3186 PS-8 Beta-lactam (carbapenem) 1982
3187 Oxanosine Natural product antibiotic (nucleoside) 1982
3188 Isopenicillin N Beta-lactam (penicillin) 1982
3189 Antibiotic U-62162 Protein synthesis inhibitor 1982
3190 Antibiotic 8006-I RNA synthesis inhibitor 1982
3191 FA-2097 Natural product antibiotic 1982
3192 Sarubicin B Natural product antibiotic 1982
3193 Ceftriaxone-sulbactam Beta-lactamase (cephalosporin) + beta-lactamase inhibitor 2007 Phase 4 (NCT04066621)
3194 Nitroxoline RNA synthesis inhibitor 1947
3195 Aldesulfone sodium Sulfone 1937 Clinical Trial (1944-1945)
3196 Aminosalicylate calcium Mycolic acid synthesis inhibitor 1950 Clinical Trial (1952)
3197 Delamanid Nitroimidazole 2006 Phase 3 (NCT01424670)
3198 Ethionamide Mycolic acid synthesis inhibitor 1960 Approved by FDA in 1965
3199 Morinamide Mycolic acid synthesis inhibitor 1962
3200 Para-aminosalicylic acid (Rezipas) Mycolic acid synthesis inhibitor 1946 Clinical Trial (1950; with streptomycin or isoniazid from 1950-1964)
3201 Protionamide Mycolic acid synthesis inhibitor 1950 Phase 3 (NCT06081361)
3202 Terizidone Oxazolidinone 1965 Phase 2/3 (NCT02454205)
3203 Tiocarlide Small molecule antibiotic 1966
3204 VA-2 DNA synthesis inhibitor 1982
3205 BA-4 Natural product antibiotic 1982
3206 BN-1 Natural product antibiotic 1982
3207 Diazaquinomycin A Folate synthesis inhibitor 1982
3208 Saphenamycin Natural product antibiotic (phenazine) 1982
3209 Precezomycin  Natural product antibiotic 2024
3211 OA-7653 Glycopeptide 1983
3212 U-56,407 Natural product antibiotic (asukamycin) 1983
3213 Y-T0678H Natural product antibiotic 1983
3214 Clerocidin DNA synthesis inhibitor 1983
3215 KA-5685 Aminoglycoside 1983
3216 Saccharocin Aminoglycoside 1983
3217 Decilorubicin Natural product antibiotic (anthracycline) 1983
3218 Ravidomycin DNA synthesis inhibitor 1983
3219 Microcin 15n Antimicrobial peptide 1983
3220 Bu-2470 Antimicrobial peptide 1983
3221 Clavalanine Natural product antibiotic 1983
3222 Safracin B Natural product antibiotic (quinone) 1983
3223 G-367 S1 Aminoglycoside 1983
3224 Tylosin Macrolide 1983
3225 Antibiotic X-14885A Natural product antibiotic (pyrrolether) 1983
3226 Curvulic Acid Cell wall synthesis inhibitor 1984
3227 Empedopeptin Lipodepsipeptide 1984
3228 Cefpirome Beta-lactam (cephalosporin, fourth-generation) 1983 Approved (not in US)
3229 Griseochelin Natural product antibiotic (carboxylic acid) 1984
3230 Penitricin Cyclopropenone 1984
3231 Antibiotic U-64846 Natural product antibiotic 1984
3232 Myxovirescin B Macrocyclic antibiotic 1984
3233 ε-Poly-L-lysine Antimicrobial peptide 1984
3234 3-methyl-7-oxo-2,3-dihydro-7H-furo [2, 3-h] pyrido [1, 2, 3-de] [1, 4] benzoxazine-6-carboxylic acid Small molecule antibiotic 1984
3235 Defucogilvocarcin V Natural product antibiotic 1985
3236 Glycocinnasperimicin D Natural product antibiotic (glycocinnamolyspermidine) 1985
3237 Sohbumycin Natural product antibiotic (peptide lactone) 1985
3238 Lavendomycin Antimicrobial peptide 1985
3239 Nourseimycin Antimicrobial peptide 1983
3240 SN-07 DNA synthesis inhibitor 1985
3241 Angiolam A Protein synthesis inhibitor 1985
3242 SF-2370 Natural product antibiotic 1985
3243 Lustromycin Natural product antibiotic (lactone) 1986
3244 SQ 30,957 Natural product antibiotic 1986
3245 3,3'-Neotrehalosadiamine Aminoglycoside 1986
3246 SF-2330 Natural product antibiotic 1986
3247 AC4437 Aminoglycoside 1986
3248 YN-0165J-A Natural product antibiotic (enteromycin) 1986
3249 Crisamicin A Natural product antibiotic (dimeric pyranonaphthoquinone) 1986
3250 Dopsisamine Natural product antibiotic 1986
3251 U-68,204 Natural product antibiotic (thiolactone-containing antibiotic) 1986
3252 Aldgamycin G Macrolide 1986
3253 Cefovecin Beta-lactam (cephalosporin) 2006
3254 Cefquinome Beta-lactam (cephalosporin) 1990
3255 Ceftiofur Beta-lactam (cephalosporin) 1987 Approved for veterinary use
3256 Danofloxacin Fluoroquinolone 1990
3257 Enrofloxacin Fluoroquinolone 1983
3258 Marbofloxacin Fluoroquinolone 1993
3259 Orbifloxacin Fluoroquinolone 1995
3260 Oxolinic acid Quinolone 1993
3261 Pradofloxacin Fluoroquinolone 2005 Approved for veterinary use
3262 Gamithromycin Macrolide 2010 Approved for veterinary use
3263 Tildipirosin Macrolide 2012 Approved for veterinary use
3264 Tilmicosin Macrolide 1987 Approved for veterinary use in 1990
3265 Tulathromycin Macrolide 2004
3266 Tylvalosin Macrolide 2008 Approved for veterinary use
3267 Cefroxadine Beta-lactam (cephalosporin) 1980
3268 Cefalonium Beta-lactam (cephalosporin) 1977
3269 Pirlimycin Lincosamide 1982
3270 Amoxicillin + clavulanic acid Beta-lactam (penicillin) + beta-lactamase inhibitor 1978 Approved by FDA in 2002
3271 Phthalylsulfathiazole Sulfa drug / Sulphonamide 1945 Clinical trial in 1945
3272 Sulfaisodimidine Sulfa drug / Sulphonamide 1946 Clinical trial in 1952
3273 Sulfamazone Sulfa drug / Sulphonamide 1972
3274 Sulfametoxydiazine Sulfa drug / Sulphonamide 1962
3275 Furaltadone Nitrofuran 1959 Clinical trial in 1959-1960
3276 Chlorhydroxyquinoline Synthetic small molecule 1953
3277 Laidlomycin Natural product antibiotic (ionophore or polyether) 1974
3278 Semduramicin Synthetic small molecule (ionophore or polyether) 1992
3279 Avilamycin Orthosomycin 1968
3280 Carbadox Quinoxaline 1972
3281 Azinothricin  Antimicrobial peptide (hexadepsipeptide) 1986
3282 9-O-propionyl-9-dihydrotylosin Macrolide 1986
3283 Cervinomycin A1 triacetate Aminoglycoside (anthracycline) 1986
3284 Cervinomycin A2 monoacetate Aminoglycoside (anthracycline) 1986
3285 Avibactam tomilopil (prodrug) Beta-lactamase inhibitor 2018
3286 Sudapyridine Diarylquinoline  2022 Phase 3 (NCT05824871)
3287 Taurolidine Synthetic small molecule 1977 Approved by FDA in 2023
3288 Pralurbactam Beta-lactamase inhibitor 2017
3289 XF-73 (exeporfinium chloride) Membrane-active agent 2023 Phase 2 (NCT03915470)
3290 JEDI-852 Lipopolysaccharide synthesis inhibitor (LpxH inhibitor) 2023
3291 MK-7762 (TBD09) Oxazolidinone 2023 Phase 1 (NCT05824091)
3292 FNDR-20081 Synthetic small molecule 2021 Preclinical
3293 TBA-354 Nitroimidazole 2010 Phase 1 (NCT02606214)
3294 OTB-658 Oxazolidinone 2020 Preclinical (approved Phase 1 clinical trial in China)
3295 3-Hydroxycezomycin Natural product antibiotic (ionophore; pyrroloether) 1987
3296 IIIM-019 Nitroimidazole 2016 Preclinical
3297 Cefepime + nacubactam Beta-lactam (cephalosporin) + beta-lactamase inhibitor 2015 Phase 3 (NCT05905055)
3298 Ceftibuten + ledaborbactam Beta-lactam (cephalosporin) + beta-lactamase inhibitor 2022 Phase 1
3299 Meropenem + pralurbactam Beta-lactam + beta-lactamase 2023 Phase 3 (NCT06633718)
3300 FNDR-20364 Antimicrobial peptide 2021 Preclinical
3301 Abbeymycin Natural product antibiotic (pyrrolobenzodiazepine) 1987
3302 Deepoxycirramycin A1 Macrolide 1987
3303 CV-1 Lipopolysaccharide synthesis inhibitor 1987
3304 Indisocin Natural product antibiotic 1987
3305 N-Methylindisocin Natural product antibiotic 1987
3306 Sch 34164 Tetracycline 1987
3307 CP-54,883 Natural product antibiotic (polyether) 1987
3308 Okilactomycin Natural product antibiotic 1987
3309 Aerocyanidin Natural product antibiotic (isonitrile containing) 1988
3310 Aerocavin Natural product antibiotic 1988
3311 Neoberninamycin Protein synthesis inhibitor 1988
3312 DOB-41 Natural product antibiotic (phenazine) 1988
3313 ABAC-39877 Small molecule antibacterial agent 2018 Preclinical
3314 MF 5137 Quinolone 1995
3315 ABAC-40244 Small molecule antibacterial agent 2024 Preclinical
3316 ABAC-40411 Small molecule antibacterial agent 2024 Preclinical
3317 ABX-605 Aminoglycoside 2019 Preclinical
3318 Andrimid Fatty acid synthesis inhibitor 1988
3319 Diffusomycin Membrane-active agent 1988
3320 Actaplanin Glycopeptide 1984
3321 A83586C Antimicrobial peptide (depsipeptide) 1988
3322 Boholmycin Aminoglycoside 1988
3323 A21978C Lipopeptide 1988
3324 16-Deethylindanomycin Membrane-active agent (ionophore) 1988
3325 SN-706 Natural product antibiotic 1988
3326 Aranorosin Natural product antibiotic 1988
3327 UK-63,052 Membrane-active agent 1989
3328 A42867  Glycopeptide 1989
3329 19-Deformyl-4'-deoxydesmycosin Macrolide 1989
3330 19-Deformyldesmycosin Macrolide 1988
3331 834-B1 Fatty acid synthesis inhibitor 1989
3332 Hatomamicin Natural product antibiotic 1989
3333 RK-699A Antimicrobial peptide 1989
3334 CP-78,545 Natural product antibiotic 1989
3335 Dynemicin A Natural product antibiotic (esperamicin/ calicheamicin) 1989
3336 Triacetyldynemicin A Natural product antibiotic (esperamicin/ calicheamicin) 1989
3337 Demycinosyltylosin  Macrolide 1989
3338 AT2433 A2 Natural product antibiotic 1989
3339 AT2433 B2 Natural product antibiotic 1989
3340 SF2487 Natural product antibiotic (polyether) 1990
3341 Kijimicin Natural product antibiotic (polyether) 1990
3342 Monazomycin B Macrolide 1990
3343 5-Formyloxymethyluridine Nucleoside analogue 1990
3344 MK4588 Natural product antibiotic (xanthocillin) 1990
3345 FR112123 Antimicrobial peptide (oligopeptide) 1990
3346 CP-80,219 Natural product antibiotic (polyether) 1990
3347 A80915 Natural product antibiotic (naphthoquinone) 1990
3348 Depsidomycin Antimicrobial peptide (heptapeptide) 1990
3349 Simaomicin Natural product antibiotic (isoquinoline) 1990
3350 Lydicamycin Natural product antibiotic 1991
3351 Hydroniddamycin derivative Macrolide 1991
3352 Tetrazomine Natural product antibiotic 1991
3353 Naphthomevalin Natural product antibiotic (naphthoquinone) 1991
3354 Methoxygriseorhodin Natural product antibiotic (naphthoquinone) 1991
3355 Aldecalmycin Natural product antibiotic 1992
3356 A83016A Natural product antibiotic (kinamycin) 1992
3357 Sporeamicin Macrolide 1992
3358 SF2457  Nucleoside analogue 1992
3359 CP-120,509 Natural product antibiotic (polyether) 1992
3360 Octacyclomycin Natural product antibiotic (polyether) 1992
3361 SO-075R1 Natural product antibiotic (anthracycline) 1992
3362 Tachyplesin I Antimicrobial peptide (cationic beta-hairpin) 1993
3363 Jadomycin B Natural product antibiotic (isoquinoline) 1993
3364 3''-Epi-erythromycin A Macrolide 1993
3365 (9S)-11-dehydroxy-9-deoxo-9-hydroxy-11-oxoerythromycin A Macrolide 1993
3366 Sperabillin derivative 29 Membrane-active agent 1993
3367 Sperabillin Membrane-active agent 1992
3368 PC-766B Macrolide 1993
3369 Azicemicin Natural product antibiotic 1993
3370 Nisamycin Natural product antibiotic (manumycin) 1993
3371 Amythiamicin Protein synthesis inhibitor 1994
3372 3,4'-Dideoxymycaminosyltylonolide derivative Macrolide 1994
3373 Cefuzonam Beta-lactam (cephalosporin, second generation) 1987
3374 N-Methylstreptothricin D Streptothricin 1994
3375 Martinomycin Natural product antibiotic (polyether) 1994
3376 Bactenecin 7, Bac7 Antimicrobial peptide 1995
3377 Leucinostatin A3 Antimicrobial peptide 1995
3378 Hexafluorotilmicosin Macrolide 1995
3379 Thiomarinol B Aminoacyl-tRNA synthetase inhibitor (isoleucyl-tRNA synthetase [Ile-RS] inhibitor) 1995
3380 Thiomarinol C Aminoacyl-tRNA synthetase inhibitor (isoleucyl-tRNA synthetase [Ile-RS] inhibitor) 1995
3381 Sorangiolid A Natural product antibiotic 1995
3382 AL072  Natural product antibiotic 1995
3383 Tetrodecamycin Natural product antibiotic (tetrodecamycin; tetronate) 1995
3384 Dihydrotetrodecamycin Natural product antibiotic (tetrodecamycin; tetronate) 1995
3385 Trichorzin HA Antimicrobial peptide 1995
3386 Trichorzin MA Antimicrobial peptide 1995
3387 Cefiderocol (QPX2014, S-649228) + Xeruborbactam (QPX7728) Beta-lactam (cephalosporin) + beta-lactamase inhibitor (boronic acid beta-lactamase inhibitor) 2023 Phase 1 (NCT06547554)
3388 9MW1411 Antibody (IgG1 mAb) 2021 Phase 2 (NCTC04784312)
3389 AP-SA02 Bacteriophage 2021 Phase 2 (NCT05184764)
3390 APT Phagebank Bacteriophage 2022 Phase 2 (NCT05269121)
3391 EcoActive Bacteriophage 2019 Phase 2 (NCT03808103)
3392 Cefepime + Ftortiazinon (fluorothyazinone) Beta-lactam (cephalosporin) + antivirulence (T3SS inhibitor) 2022 Phase 2
3393 LMN-101 Antibody 2019 Phase 2 (NCT04182490)
3394 OligoG Biopolymer 2011 Phase 2 (NCT01465529)
3395 PP1493 and PP1815 Bacteriophage 2022 Phase 2 (NCT05369104)
3396 Reltecimod Immunomodulator agent 2011 Phase 3 (NCT03403751)
3397 Rhu-pGSN Immunomodulator agent 2015 Phase 2
3398 ShigActive Bacteriophage 2015 Phase 2 (NCT05182749)
3399 VRELysin Bacteriophage 2023 Phase 2 (NCT05715619)
3400 YPT-01 Bacteriophage and phage-derived enzyme 2020 Phase 2 (NCT04684641)
3401 CC-11050 Immunomodulator agent 2016 Phase 2 (NCT03807362)
3402 SQ109 Ethylenediamine 2005 Phase 2
3403 ADS024 Microbiome modulating agent 2022 Phase 1 (NCT04891965)
3404 IM-01 Antibody 2017 Phase 2 (NCT04121169)
3405 LMN-201 Bacteriophage and phage-derived enzyme 2022 Phase 3
3406 MBK-01 Microbiome modulating agent 2022 Phase 3
3407 NTCM-M3 Microbiome modulating agent 2012 Phase 2 (NCT01259726)
3408 RBX7455 Microbiome modulating agent 2020 Phase 1 (NCT02981316)
3409 Ribaxamase Microbiome modulating agent 2016 Phase 2
3410 VE303 Microbiome modulating agent 2022 Phase 2
3411 SVT-1C469, SVT 1C469, SVT1C469 Microbiome modulating agent 2020 Phase 1 (ACTRN12620000923965)
3412 CRS0393 Mycolic acid synthesis inhibitor 2018 Preclinical
3413 CZ-02 Protein synthesis inhibitor 2023 Preclinical
3414 EB003 Microbiome modulating agent 2021 Preclinical
3415 LptA-OMPTA Antimicrobial peptide 2022 Preclinical
3416 MBX-16 Small molecule antibacterial agent Preclinical
3417 BE-24566B Natural product antibiotic 1995
3418 Sapecin B derivative Antimicrobial peptide 1996
3419 Carboxamide eremomycin Glycopeptide 1996
3420 YM-30059 Quinolone 1996
3421 Nisin Z Antimicrobial peptide 1996
3422 Tobicillin  Beta-lactam 1997
3423 250-144C Macrolide 1997
3424 Thiomarinol D Aminoacyl-tRNA synthetase inhibitor (isoleucyl-tRNA synthetase [IleRS] inhibitor) 1997
3425 Korormicin Natural product antibiotic (lactone) 1997
3426 YM-47515 Natural product antibiotic (isonitrile) 1997
3427 1-Hydroxycrisamicin A Natural product antibiotic (naphthoquinone) 1998
3428 Polyketomycin Natural product antibiotic 1998
3429 Cremimycin  Natural product antibiotic (macrocyclic lactam) 1998
3430 N-alkyl Demethylvancomycin  Glycopeptide 1998
3431 LL-49F233 alpha Membrane-active agent 1998
3432 Diperamycin Antimicrobial peptide 1998
3433 BE-40665D Natural product antibiotic 1999
3434 Lactonamycin Natural product antibiotic (naphthoquinone) 1999
3435 Hinokitiol Membrane-active agent 1999
3436 Beta-dolabrin   Natural product antibiotic 1999
3437 Vinylamycin  Antimicrobial peptide 1999
3438 Tylopeptin Antimicrobial peptide 1999
3439 Streptopyrrole Antivirulence agent 1998
3440 UCS1025A Natural product antibiotic (polyketide) 2000
3441 Piptamine Natural product antibiotic 2000
3442 Xanthoepocin Natural product antibiotic 2000
3443 Tubelactomicin A Natural product antibiotic (lactone) 2000
3444 Micacocidin Natural product antibiotic (thiazoline) 2001
3445 CJ-17,665 Natural product antibiotic 2001
3446 CJ-15,801 CoA synthesis inhibitor 2001
3447 Apolipoprotein Antimicrobial peptide 2002
3448 YM-181741 Natural product antibiotic 2002
3449 CJ-17,572 Natural product antibiotic (tetramic acid) 2002
3450 Pseudopyronine B Natural product antibiotic 2002
3451 3-Keto tylosin derivative Macrolide 2002
3452 Chalcomycin B Macrolide 2002
3453 Altersetin  Natural product antibiotic 2002
3454 Chloroquinocin Natural product antibiotic (naphthoquinone) 2002
3455 Coniosetin  Natural product antibiotic 2003
3456 Erythromycin G Macrolide 2003
3457 Seitomycin  Natural product antibiotic (angucycline) 2003
3458 Helquinoline  Natural product antibiotic (quinoline) 2004
3459 Mutactimycin PR Natural product antibiotic (anthracycline) 2004
3460 Carnosol  Membrane-active agent 2007
3461 CW-270033 Beta-lactam (carbapenem) 2007
3462 Oleanolic Acid Natural product antibiotic 2007
3463 D-9-mer peptides (diastereomer) Antimicrobial peptide 2007
3464 Glioperazine B Antimicrobial peptide (diketopiperazine) 2007
3465 Rhodomyrtone Natural product antibiotic (acylphloroglucinol) 2008
3466 Morinol Natural product antibiotic 2009
3467 Des-fatty acyl-polymyxin B decapeptide derivative Antimicrobial peptide 2009
3468 12α-Hydroxyfriedelane-3,15-dione Natural product antibiotic 2009
3469 Cycloundecapeptide Antimicrobial peptide 2011
3470 Triclosan Synthetic small molecule antibacterial agent 1964 Approved by FDA in 1997
3471 Sy142 Oxazolidinone 2014
3472 E-4502 Fluoroquinolone 1990
3473 E-4501, E4501, E 4501 Fluoroquinolone 1990
3474 E-4500, E4500, E 4500 Fluoroquinolone 1990
3475 E-4480, E4480, E 4480 Fluoroquinolone 1990
3476 E-4474, E4474, E 4474 Fluoroquinolone 1990
3477 E-4441, E4441, E 4441 Fluoroquinolone 1990
3478 Bactenecin 5 Antimicrobial peptide 1989
3479 Irloxacin Fluoroquinolone 1987
3480 Bay v 3522 Beta-lactam (cephalosporin) 1990
3481 Cefcanel Beta-lactam 1989
3482 Plantamajoside Antivirulence agent (sortase inhibitor) 2024
3483 Safencin E Antimicrobial peptide (bacteriocin) 2024
3484 Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) Efflux pump inhibitor 2021
3485 MGC-10 Protein synthesis inhibitor (elongation factor [EF-Tu] inhibitor) 2024
3486 Hs02 Antimicrobial peptide 2024
3487 LC-AMP-I1 Antimicrobial peptide 2024
3488 Doxifluridine Small molecule antibacterial agent 2017
3489 α-Mangostin derivative 4 Membrane-active agent 2024
3490 P-92 Antimicrobial peptide 2024
3491 MRS-2541 Aminoacyl-tRNA synthetase inhibitor (methionyl tRNA synthetase [MetRS] inhibitor) 2024
3492 Arcanocin Antimicrobial peptide 2024
3493 Arachnicin Antimicrobial peptide 2024
3494 AMP-W5 Antimicrobial peptide 2024
3495 Benzo[c]phenanthridine derivative 6 Small molecule antibacterial agent 2024
3496 Benzo[c]phenanthridine derivative 9 Small molecule antibacterial agent 2024
3497 MBX-4888A Aminoglycoside 2016 Preclinical
3498 GuaBi G1 Nucleotide synthesis inhibitor 2024
3499 GuaBi G2 Nucleotide synthesis inhibitor 2024
3500 Dihydromycoplanecin Antimicrobial peptide 1985
3501 Merafloxacin Fluoroquinolone 1984
3502 RU-985 Macrolide 1986
3503 Mederrhodin A Natural product antibiotic (medermycin) 1986
3504 3-de-O-methylsporaricin A sulfate Aminoglycoside 1982
3505 Zidovudine DNA synthesis inhibitor 1990
3506 Isorhapontigenin  Antivirulence agent 2024
3507 A20L  Antimicrobial peptide 2015
3508 Serrawettin W2-FL10 Lipopeptide 2022
3509 Demethoxycurcumin, Amb2698241 Small molecule antibacterial agent 2024
3510 (+)-Brazilin Antibiofilm agent 2018
3511 EC1 Bacteriophage lysin 2024
3512 D66  Membrane-active agent 2022
3513 Thiazolidinone derivative Small molecule antibiotic 2024
3514 Cd-IF1 Antimicrobial peptide 2024
3515 Phenylimidazole analogue 296 Fatty acid synthesis inhibitor (FabK inhibitor) 2019
3516 VesiX CPC Membrane-active agent 2022 Limited clinical trial
3517 1D10 Lysin 1999
3518 Turnercyclamycin  Lipopeptide 2021
3519 Microcin Y Antimicrobial peptide (lasso peptide) 2021
3520 Bilothiazole E Natural product antibiotic (thiazole) 2025
3521 Bilothiazole F Natural product antibiotic (thiazole) 2025
3522 AD101 Protein synthesis inhibitor Preclinical
3523 Disperazol Antibiofilm agent 2024
3524 CVH-88 Pleuromutilin  2020
3525 CVH-174 Pleuromutilin 2024
3526 Lysocin E Lipopeptide 2014
3527 Nosokomycin Natural product antibiotic 2010
3528 Xenorceptide A2 BamA inhibitor 2025
3529 Vancomycin polycationic peptide conjugate (VN-R6C) 2020
3530 BT-33 Protein synthesis inhibitor 2024
3531 SRI-12742 Small molecule antibiotic 2018
3532 Ceftazidime-hexa-arginine conjugate (CTZ-R6) Beta-lactam 2024
3533 BioTryp small molecule inhibitor Antibiofilm agent
3534 5-Nitrofuran-2-carbohydrazide 21f Sulfa drug / Sulphonamide 2015
3535 Beetle-defensin derived AMP Antimicrobial peptide 1999
3536 Epigallocatechin gallate (EGCG) Natural product antibiotic 2016
3537 6-Phenylnicotinohydrazide derivative 8b Small molecule antibacterial agent 2017
3538 WFQ-228 Fluoroquinolone 2018
3539 Bismuth lipophilic nanoparticle (BisBAL NP)  Nanoparticle 2019
3540 Graphene oxide (GO) and the antimicrobial peptide (AMP) Nal-P-113 Antimicrobial peptide 2022
3541 Antibiotic 1599 Spectinamide 2015
3542 Amidino-urea 1-[(2,6-diethylphenyl)-3-N-ethylcarbamimodoyl]urea PptT inhibitor 2019
3543 Benzofuroxan derivative 8 Protein synthesis inhibitor 2017
3544 Bortezomib derivative 58 Small molecule antibacterial agent 2017
3545 SATB-082 DNA synthesis inhibitor (DnaN inhibitor) 2015
3546 GSK 724A Mycolic acid synthesis inhibitor 2016
3547 GSK693  Fatty acid synthesis inhibitor (InhA inhibitor) 2016
3548 GSK839 Tryptophan synthase inhibitor Preclinical
3549 Imatinib Small molecule antibacterial agent 2012
3550 NITD-304 Mycolic acid synthesis inhibitor 2013 Preclinical
3551 NITD-349 Mycobacterial cell wall synthesis inhibitor 2013 Preclinical
3552 JSF-3285 Mycolic acid synthesis inhibitor 2020
3553 NTB-3119 Mycolic acid synthesis inhibitor (DprE1 inhibitor) 2018
3554 SQ609 Mycolic acid synthesis inhibitor 2012
3555 Sulfolane Tryptophan synthesis inhibitor 2017
3556 TB47 QcrB inhibitor 2015 Preclinical
3557 Tryptanthrin analogue 5 Small molecule antibacterial agent 2019
3558 NSC19723 Mycolic acid synthesis inhibitor 2020
3559 11726172 Membrane-active agent 2022
3560 24,25-Dihydrofusidic acid Fusidane 1966
3561 KW13 Antimicrobial peptide 2025
3562 AI18 Antimicrobial peptide 2025
3563 FI19 Antimicrobial peptide 2025
3564 XT17  Membrane-active agent 2025
3565 Erucamide Antivirulence agent (T3SS) 2025
3566 F3FT  Antimicrobial peptide (nanopeptide) 2025
3567 N3FT  Antimicrobial peptide (nanopeptide) 2025
3568 GmPcide PS757  Membrane-active agent 2022
3569 ZnBq/Ce6@ZIF-8@OMV Membrane-active agent 2024
3570 COE-PNH2 Membrane-active agent 2024
3571 Sviceucin Antimicrobial peptide (lasso peptide) 2025
3572 Macrosporusone A Antivirulence agent 2025
3573 NSC 18725 Small molecule antibacterial agent 2020
3574 DCB001 Small molecule antibacterial agent
3575 SPR113 Preclinical
3576 Ligustroflavone Antivirulence agent 2025
3577 Microcin J25 Antimicrobial peptide (lasso peptide) 1992
3578 Capistruin Antimicrobial peptide (lasso peptide) 2008
3579 Lariocidin B Antimicrobial peptide (lasso peptide) 2025
3580 CLB073 2023 Preclinical
3581 S-004992 Small molecule antibacterial agent 2018 Preclinical
3582 TBK-613 Fluoroquinolone 2009 Preclinical
3583 Dapsone Sulfa drug / Sulphonamide 1937 Approved by FDA in 1979
3584 Isoxazole M1 Mycolic acid synthesis inhibitor 2024
3585 Compound 42 Small molecule antibacterial agent 2013
3586 V13KL Antimicrobial peptide 2005
3587 Rosoxacin Quinolone 1980 Approved
3588 O-Demethylfortimicin A Aminoglycoside 1980
3589 R-type pyocin 611 131 Antimicrobial peptide (bacteriocin) 1980
3590 Rhoifolin Antivirulence agent 2025
3591 Miloxacin Quinolone 1980
3592 Mycoidesin Antimicrobial peptide (lantibiotic) 2025
3593 Aridicin A Glycopeptide 1985
3594 Probenicid Small molecule antibacterial agent 1984
3595 2',3'-Dideoxyadenosin DNA synthesis inhibitor 1981
3596 YM-13115 Beta-lactam (cephalosporin) 1985
3597 A47934 Glycopeptide 1986
3598 UK-38,006 Beta-lactamase inhibitor 1981
3599 Satranidazole Nitroimidazole 1986
3600 Microcin 7 Antimicrobial peptide 1985
3601 Cecropin-4 Antimicrobial peptide 2019
3602 Ro 13-9904 Beta-lactam (cephalosporin) 1980
3603 Microcin 15m Antimicrobial peptide 1982
3604 N,N'-Dialkylpolymethylenediamine Small molecule antibacterial agent 1989
3605 Habekacin Aminoglycoside 1973
3606 Foramidocillin Beta-lactam 1986
3607 Antibiotic BB-K311 Aminoglycoside 1981
3608 ICI 193428 Beta-lactam 1987
3609 ICI 194008 Beta-lactam 1987
3610 Grahamimycin A Natural product antibiotic 1981
3611 BK-218 Beta-lactam 1990
3612 Microcin D93 Antimicrobial peptide 1986
3613 Microcin B17 Antimicrobial peptide 1987
3614 Helveticin J Antimicrobial peptide 1986
3615 Neodiosmin Antivirulence agent 2025
3616 Pentamidine isethionate Small molecule antibacterial agent 1990
3617 N-[4-(1-hydroxy-6-nitrobenzimidazol-2-yl)phenyl]-4-(1,3-oxazol-5-yl)benzamide Antivirulence agent (T3SS inhibitor) 2010
3618 2-Propenamide, 3-(4-fluorophenyl)-N-[4-(1-hydroxy-6-nitro-1H-benzimidazol-2-yl)phenyl]-, (2E)- Antivirulence agent (T3SS inhibitor) 2010
3619 ME1071 Beta-lactamase inhibitor (MBL inhibitor) 2010
3620 Ceftolozane Beta-lactam (cephalosporin) 2007 Approved by FDA in 2014
3621 DiPGLa-H Antimicrobial peptide 2025
3622 Piperazinylsulfonylaryl compound Small molecule antibacterial agent 2021
3623 1,2,4-triazine-based compound Small molecule antibacterial agent 2010
3624 Aminoacyl adenylate mimic Protein synthesis inhibitor 1997
3625 ANASIA Protein synthesis inhibitor 2021
3626 MAC13243 Small molecule antibacterial agent 2009
3627 (3S,4S)-4-((3-fluoro-4'-((S)-4-hydroxy-3-(2-((S)-1-hydroxyethyl-1H-imidazol-1-yl)but-1-yn-1-yl)-[1,1'-biphenyl]-4-4-yl)methoxy)tetrahydrofuran-3-ol Lipopolysaccharide synthesis inhibitor 2024
3628 Aromatic acetylene derivative 13 Lipopolysaccharide synthesis inhibitor 2023
3629 Antibiotic TAN 1057 Natural product antibiotic 1989
3630 JNJ-6640 Small molecule antibacterial agent 2025
3631 Triazolopyrimidine compound 24 Small molecule antibacterial agent 2025
3632 Triazolopyrimidine compound 33 Small molecule antibacterial agent 2025
3633 N-(5-Benzyl-thiazol-2-yl)-2-[4-(4-methoxy-phenyl)-1H-tetrazol-5-ylsulfanyl]-acetamide Small molecule antibacterial agent 2025
3634 FG-2101 Small molecule antibacterial agent 2025 Preclinical

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